Baptiste Darracq
@baptistedarracq.bsky.social
PhD student in the PGB lab at Institut Pasteur | integrons, bacterial immunity
😜😜 Thanks Basile
May 9, 2025 at 5:23 PM
😜😜 Thanks Basile
Reposted by Baptiste Darracq
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
May 8, 2025 at 8:27 PM
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Have also a look at our back-to-back study for mobile integrons by Nicolas Kieffer from @jaescudero.bsky.social group !
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 9, 2025 at 11:41 AM
Have also a look at our back-to-back study for mobile integrons by Nicolas Kieffer from @jaescudero.bsky.social group !
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
An enormous thanks for the great co-first author @eloilittner.bsky.social and for our supervisors @celineloot.bsky.social @epcrocha.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social. Many thanks to all co-authors !!
May 9, 2025 at 11:41 AM
An enormous thanks for the great co-first author @eloilittner.bsky.social and for our supervisors @celineloot.bsky.social @epcrocha.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social. Many thanks to all co-authors !!
On the bioinformatic side, eloilittner.bsky.social found a diverse arsenal of anti-phage defenses in SCIs. Strikingly, systems in integrons are always compact (< 3 genes), and smaller than their homologs outside integrons (likely due to cassette size constraints)
May 9, 2025 at 11:41 AM
On the bioinformatic side, eloilittner.bsky.social found a diverse arsenal of anti-phage defenses in SCIs. Strikingly, systems in integrons are always compact (< 3 genes), and smaller than their homologs outside integrons (likely due to cassette size constraints)
The integron of our favorite model Vibrio cholerae was mostly “dark matter” as most cassettes had no known role. We found this intriguing and cloned 88 cassettes, testing them for phage resistance. We found 16 defensive cassettes and named the systems after gallic mythology
May 9, 2025 at 11:41 AM
The integron of our favorite model Vibrio cholerae was mostly “dark matter” as most cassettes had no known role. We found this intriguing and cloned 88 cassettes, testing them for phage resistance. We found 16 defensive cassettes and named the systems after gallic mythology