Pratiti (Mimi) Bandopadhayay
@bandolab.bsky.social
www.bandolab.org
Genomic approaches for childhood brain tumors
Pediatric Neuro-Oncologist/Scientist
@DanaFarber, @Broadinstitute, @BostonChildrens
Views are my own
Genomic approaches for childhood brain tumors
Pediatric Neuro-Oncologist/Scientist
@DanaFarber, @Broadinstitute, @BostonChildrens
Views are my own
Reposted by Pratiti (Mimi) Bandopadhayay
This was a fun project with John Rhee and Charlotta Lindvall on using LLMs to scour medical records. It has been wonderful to work with them!
secure-web.cisco.com/1QgAtJ9SFoCj...
secure-web.cisco.com/1QgAtJ9SFoCj...
Scalable Tracking of Symptoms in the Electronic Health Record using Large Language Models in Patients with Central Nervous System Cancers Undergoing Therapy
AbstractBackground. Advances in large language models (LLMs) provide a means for scalable tracking of patient symptoms in clinical trials and post-marking
secure-web.cisco.com
September 18, 2025 at 5:30 PM
This was a fun project with John Rhee and Charlotta Lindvall on using LLMs to scour medical records. It has been wonderful to work with them!
secure-web.cisco.com/1QgAtJ9SFoCj...
secure-web.cisco.com/1QgAtJ9SFoCj...
Everyone needs to watch this. Our children deserve better. They need MORE funding, resources and research. Not less. lnkd.in/gevV3Gth
#pediatriccancerawareness | René Marsh
Federal funding for a pediatric brain cancer network of top doctors, scientists and hospitals across the country is being cut. Health and Human Services tells CNN the cut is for efficiency.
The Pedi...
lnkd.in
September 3, 2025 at 11:28 AM
Everyone needs to watch this. Our children deserve better. They need MORE funding, resources and research. Not less. lnkd.in/gevV3Gth
Excited to get this out there as we go through revisions. These findings have changed how I think about KIAA1549-BRAF of pediatric gliomas, and all other fusions, completely.
The fusion partner is important, necessary and engenders novel vulnerabilities that can be therapeutically targeted.
The fusion partner is important, necessary and engenders novel vulnerabilities that can be therapeutically targeted.
Together with @glyco.me, @bandolab.bsky.social and teams, we recently uncovered a link between pediatric brain tumors, POMT1/2 enzymes and KIAA1549 - full story in the preprint below:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis
Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with partner that does not independently drive cancer. In all therapeutically actio...
www.biorxiv.org
August 23, 2025 at 9:31 PM
Excited to get this out there as we go through revisions. These findings have changed how I think about KIAA1549-BRAF of pediatric gliomas, and all other fusions, completely.
The fusion partner is important, necessary and engenders novel vulnerabilities that can be therapeutically targeted.
The fusion partner is important, necessary and engenders novel vulnerabilities that can be therapeutically targeted.
Reposted by Pratiti (Mimi) Bandopadhayay
Terrible news for pediatric brain tumor research and incredible amount of hard work wasted. This very likely will result in some active trials prematurely closing without sufficient accrual to answer their aims.
Devastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children.
These children need MORE funding and MORE trials, not less.
They deserve better
These children need MORE funding and MORE trials, not less.
They deserve better
August 20, 2025 at 1:00 AM
Terrible news for pediatric brain tumor research and incredible amount of hard work wasted. This very likely will result in some active trials prematurely closing without sufficient accrual to answer their aims.
Reposted by Pratiti (Mimi) Bandopadhayay
Every dollar invested by the federal government on health research returns $2.60 in economic activity, not to mention the benefits to our health. The federal government spends very little on biomedical research as it is; it is so counterproductive to cut what remains. ☹️
August 20, 2025 at 6:39 PM
Every dollar invested by the federal government on health research returns $2.60 in economic activity, not to mention the benefits to our health. The federal government spends very little on biomedical research as it is; it is so counterproductive to cut what remains. ☹️
Devastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children.
These children need MORE funding and MORE trials, not less.
They deserve better
These children need MORE funding and MORE trials, not less.
They deserve better
August 19, 2025 at 10:41 PM
Devastating news. The Pediatric Brain Tumor Consortium has lost its ability to apply for federal funding upon which it is structured. Without this, it cant exist. This threatens access to clinical trials for children.
These children need MORE funding and MORE trials, not less.
They deserve better
These children need MORE funding and MORE trials, not less.
They deserve better
Excited to share our paper reporting significance of FGFR-alterations across pediatric gliomas. Congratulations April Apfelbaum and Eric Morin and to everyone across our labs and collaborators. Thank you to the foundations and patients/ families who made this happen. www.bandolab.org
rdcu.be/eyHcG
rdcu.be/eyHcG
A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas
Nature Communications - A subset of pediatric gliomas harbour alterations in fibroblast growth factor receptor (FGFR)-family proteins. Here, the authors characterise the genomic landscape of 11,635...
rdcu.be
July 31, 2025 at 1:34 PM
Excited to share our paper reporting significance of FGFR-alterations across pediatric gliomas. Congratulations April Apfelbaum and Eric Morin and to everyone across our labs and collaborators. Thank you to the foundations and patients/ families who made this happen. www.bandolab.org
rdcu.be/eyHcG
rdcu.be/eyHcG
Excited to be part of the editorial team for the FIRST journal specifically focused on pediatric brain tumors. Submissions now open!
💪Neuro-Oncology Pediatrics – a new open access journal by EANO & @neuroonc.bsky.social for the global #pediatric & AYA #NeuroOncology community. Now open for submissions!
🔗 academic.oup.com/neuro-onc-peds
Editor-in-Chief: S. Mueller
Executive Editors: M. A. Roldán (EANO), @bandolab.bsky.social (SNO)
🔗 academic.oup.com/neuro-onc-peds
Editor-in-Chief: S. Mueller
Executive Editors: M. A. Roldán (EANO), @bandolab.bsky.social (SNO)
May 21, 2025 at 5:56 PM
Excited to be part of the editorial team for the FIRST journal specifically focused on pediatric brain tumors. Submissions now open!
An inspirational (and fun) few days of science at the joint Bando-Beroukhim-Ligon Labs retreat in Maine. Joined by Nada Jabado, Claudia Kleinman and Veronica Rendo. We are all on the mission together to find better treatments for our kids #BandoLab
May 15, 2025 at 1:03 PM
An inspirational (and fun) few days of science at the joint Bando-Beroukhim-Ligon Labs retreat in Maine. Joined by Nada Jabado, Claudia Kleinman and Veronica Rendo. We are all on the mission together to find better treatments for our kids #BandoLab
A fun project with @rameenberoukhim.bsky.social and @vrendo.bsky.social focused on how the interplay between structural variants at the BRD4 locus fine tunes its expression. Congratulations to Jeremiah, Simona, Sophie and team, and also to Veronica! Looking forward to many more collaborations ahead.
📣 Online now! Our study shows how recurrent focal deletions constitute a mechanism by which cancer cells can dampen toxicity due to gene amplification.
www.cell.com/cell-genomic...
🧵👇:
www.cell.com/cell-genomic...
🧵👇:
Recurrent breakpoints in the BRD4 locus reduce toxicity associated with gene amplification
Wala et al. identify recurrent focal BRD4 deletions in tumors harboring larger amplifications,
suggesting that these deletions may serve to limit toxic BRD4 overexpression. A CRISPR-Cas9
cell line mod...
www.cell.com
March 20, 2025 at 11:14 AM
A fun project with @rameenberoukhim.bsky.social and @vrendo.bsky.social focused on how the interplay between structural variants at the BRD4 locus fine tunes its expression. Congratulations to Jeremiah, Simona, Sophie and team, and also to Veronica! Looking forward to many more collaborations ahead.
Congratulations to @vrendo.bsky.social. Very excited for the amazing science that is still to come from the Rendo Lab for our kids with brain tumors
Today we celebrated my official Group Leader appointment and paper publications with bubbles and prinsesstårta, the Swedish way! 🍰🥂🍾 Skål!
February 27, 2025 at 8:41 PM
Congratulations to @vrendo.bsky.social. Very excited for the amazing science that is still to come from the Rendo Lab for our kids with brain tumors
The Bando and Beroukhim Labs (www.bandolab.org, www.beroukhimlab.org) are seeking a Senior Scientist to help find better treatments for children with brain tumors. More details here: careers.dana-farber.org/job/11089/sr...
@rameenberoukhim.bsky.social #BandoLab #DFCI @broadinstitute.org
@rameenberoukhim.bsky.social #BandoLab #DFCI @broadinstitute.org
Research Laboratory Job: Sr Scientist - Bandopadhayay Lab at Dana-Farber Cancer Institute in 450 Brookline Ave, Boston, MA
Sr Scientist - Bandopadhayay Lab job
careers.dana-farber.org
February 27, 2025 at 8:40 PM
The Bando and Beroukhim Labs (www.bandolab.org, www.beroukhimlab.org) are seeking a Senior Scientist to help find better treatments for children with brain tumors. More details here: careers.dana-farber.org/job/11089/sr...
@rameenberoukhim.bsky.social #BandoLab #DFCI @broadinstitute.org
@rameenberoukhim.bsky.social #BandoLab #DFCI @broadinstitute.org
Reposted by Pratiti (Mimi) Bandopadhayay
So excited to see this paper out! An example of how window of opportunity trials can help dissect the mechanisms of response and resistance associated with targeted therapies in glioblastoma 🧠
www.science.org/doi/10.1126/...
Thanks to the patients and scientific team who made this study possible.
www.science.org/doi/10.1126/...
Thanks to the patients and scientific team who made this study possible.
A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma
In patients with glioblastoma, navtemadlin resistance is not mediated by TP53-inactivating mutations, and combination with TMZ may improve efficacy.
www.science.org
February 19, 2025 at 9:07 PM
So excited to see this paper out! An example of how window of opportunity trials can help dissect the mechanisms of response and resistance associated with targeted therapies in glioblastoma 🧠
www.science.org/doi/10.1126/...
Thanks to the patients and scientific team who made this study possible.
www.science.org/doi/10.1126/...
Thanks to the patients and scientific team who made this study possible.
Reposted by Pratiti (Mimi) Bandopadhayay
With an aim to drive collaborative team science & in honor of our remarkable #CARTcell patients, we started the annual Cleveland Hood Lecture w/ Dr Neev Manoharan of Sydney Children’s Hospital as our inaugural speaker. It’s a privilege to build intercontinental alliances against childhood cancer ❤️🔬
February 6, 2025 at 3:59 AM
With an aim to drive collaborative team science & in honor of our remarkable #CARTcell patients, we started the annual Cleveland Hood Lecture w/ Dr Neev Manoharan of Sydney Children’s Hospital as our inaugural speaker. It’s a privilege to build intercontinental alliances against childhood cancer ❤️🔬
Congratulations to @johnprensner.bsky.social and the entire team!
Looking to see how #RiboSeq can improve your cancer research?
Check out how we've been developing new methods to study #medulloblastoma and other forms of #childhoodcancer.
Out in @naturecomms.bsky.social now. Thanks to Jim Clauwaert and Gerben Menschaert as well!
www.nature.com/articles/s41...
Check out how we've been developing new methods to study #medulloblastoma and other forms of #childhoodcancer.
Out in @naturecomms.bsky.social now. Thanks to Jim Clauwaert and Gerben Menschaert as well!
www.nature.com/articles/s41...
Deep learning to decode sites of RNA translation in normal and cancerous tissues - Nature Communications
RNA translation is a core cell process that is deregulated in cancer. Here, the authors show that a machine learning approach, RiboTIE, can reconstruct RNA translation in cancer and non-cancer cells. ...
www.nature.com
February 2, 2025 at 10:47 PM
Congratulations to @johnprensner.bsky.social and the entire team!
Reposted by Pratiti (Mimi) Bandopadhayay
Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬
BrainChild-03 Trial Supports Safety of B7-H3 CAR T-cell Therapy for DIPG
Main Finding: A phase I trial supported the safety and feasibility of repeated intracranial infusions of B7-H3 CAR T cells for DIPG.Concept: B7-H3 is an immunoregulatory protein expressed on the surfa...
aacrjournals.org
January 28, 2025 at 6:48 PM
Honored to have our recently published first-in-human phase 1 clinical trial of repeatedly dosed intracerebroventrocular B7-H3 #CARTcells for children with #DIPG highlighted in @theaacr.bsky.social and #CancerDiscovery Research Watch ❤️🔬
Proud to share this preprint on behalf of Nico, Daren and team with some insights that we hope will be helpful to those modeling K27M mutations in histone proteins. #BandoLab
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
N-terminal modification of Histone H3 inhibits H3K27M-mediated loss of H3K27 trimethylation
The use of short epitope tags is widespread in the study of histone H3 biology as they allow for the antibody-mediated detection and pulldown of particular histone post-translational modifications (PT...
www.biorxiv.org
January 28, 2025 at 5:09 PM
Proud to share this preprint on behalf of Nico, Daren and team with some insights that we hope will be helpful to those modeling K27M mutations in histone proteins. #BandoLab
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pratiti (Mimi) Bandopadhayay
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.
www.cell.com
January 2, 2025 at 8:03 PM
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
A proud mentor moment! Congratulations to Jenna! We are so excited to have you in our team and working for children with brain tumors to find more effective and less toxic treatments.
Www.bandolab.org @broadinstitute.org #DFCI #SNO2024 #ISPNO
Www.bandolab.org @broadinstitute.org #DFCI #SNO2024 #ISPNO
November 23, 2024 at 5:23 PM
A proud mentor moment! Congratulations to Jenna! We are so excited to have you in our team and working for children with brain tumors to find more effective and less toxic treatments.
Www.bandolab.org @broadinstitute.org #DFCI #SNO2024 #ISPNO
Www.bandolab.org @broadinstitute.org #DFCI #SNO2024 #ISPNO
#SNO2024…… my first BlueSky meeting! Excited to connect with friends, colleagues and collaborators and brainstorm around our projects focused on pediatric brain tumors. Www.bandolab.org #teamscience #PedBrainTumors #BandoLab #DFCI @broadinstitute.org
We are on this mission together
We are on this mission together
November 21, 2024 at 2:31 PM
#SNO2024…… my first BlueSky meeting! Excited to connect with friends, colleagues and collaborators and brainstorm around our projects focused on pediatric brain tumors. Www.bandolab.org #teamscience #PedBrainTumors #BandoLab #DFCI @broadinstitute.org
We are on this mission together
We are on this mission together
Our Blue Skies repost of April and Eric's preprint, on behalf of the www.bandolab.org, Ligon Lab, David Jones, and collaborators, focused on FGFR-alterations in pediatric gliomas. #TeamScience #PedBrainTumors @broadinstitute.bsky.social #DanaFarber @dkfz.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A diverse landscape of FGFR alterations and co-mutations defines novel therapeutic strategies in pediatric low-grade gliomas
Alterations in Fibroblast growth factor receptor (FGFR)-family proteins frequently occur as oncogenes in many cancers, including a subset of pediatric gliomas. Here, we performed a genomic analysis of...
www.biorxiv.org
November 18, 2024 at 3:38 AM
Our Blue Skies repost of April and Eric's preprint, on behalf of the www.bandolab.org, Ligon Lab, David Jones, and collaborators, focused on FGFR-alterations in pediatric gliomas. #TeamScience #PedBrainTumors @broadinstitute.bsky.social #DanaFarber @dkfz.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Hello to the Blue Sky community! Excited to join on behalf of www.bandolab.org! We are on a mission to find more effective and less toxic treatments for children with brain tumors
Bandopadhayay Lab at Dana-Farber Cancer Institute
The Bandopadhayay Lab applies genomics to characterize driver alterations that contribute to pediatric brain tumor formation and to develop strategies to therapeutically target them.
www.bandolab.org
November 11, 2024 at 1:47 AM
Hello to the Blue Sky community! Excited to join on behalf of www.bandolab.org! We are on a mission to find more effective and less toxic treatments for children with brain tumors