Adnan Halim
@manno.se
I (still) handle advanced mass spec instruments in the lab. Pack columns, optimize chromatography. Design and perform complicated experiments that span weeks, sometimes months. Yet, my wife doesn’t trust me with the washing machine 😣
August 24, 2025 at 10:55 AM
I (still) handle advanced mass spec instruments in the lab. Pack columns, optimize chromatography. Design and perform complicated experiments that span weeks, sometimes months. Yet, my wife doesn’t trust me with the washing machine 😣
Together with @glyco.me, @bandolab.bsky.social and teams, we recently uncovered a link between pediatric brain tumors, POMT1/2 enzymes and KIAA1549 - full story in the preprint below:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis
Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with partner that does not independently drive cancer. In all therapeutically actio...
www.biorxiv.org
August 23, 2025 at 5:22 PM
Together with @glyco.me, @bandolab.bsky.social and teams, we recently uncovered a link between pediatric brain tumors, POMT1/2 enzymes and KIAA1549 - full story in the preprint below:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adnan Halim
Recently came across this during lit review. A solid mechanistic study with a big performance improvement as a result.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine
N-Hydroxysuccinimide (NHS) ester chemistry is used extensively across proteomics sample preparation. One of its increasingly prevalent applications is…
www.sciencedirect.com
March 28, 2025 at 10:36 AM
Recently came across this during lit review. A solid mechanistic study with a big performance improvement as a result.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The outfit is a subtle hint: O-Man, O-GalNAc with some GlcNAc 🟢🟨🟦
March 25, 2025 at 4:34 PM
The outfit is a subtle hint: O-Man, O-GalNAc with some GlcNAc 🟢🟨🟦
Impressive study from Heck lab www.nature.com/articles/s41...
In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer - Nature Communications
While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for N-glycopeptides, nGlycoDIA, ena...
www.nature.com
March 14, 2025 at 7:56 AM
Impressive study from Heck lab www.nature.com/articles/s41...
Reposted by Adnan Halim
It’s #glycotime Fucosyltransferases FUT10 and FUT11 are protein O-fucosyltransferases (POFUTs) modifying proteins with elastin microfibril interface (EMI) domains. Curious to know the function(s) of O-fucosylating EMI domains
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains - Nature Chemical Biology
FUT10 and FUT11, originally annotated as α1,3-fucosyltransferases, are actually protein O-fucosyltransferases participating in a non-canonical ER quality control pathway for EMI domain-containing prot...
www.nature.com
January 8, 2025 at 10:21 PM
It’s #glycotime Fucosyltransferases FUT10 and FUT11 are protein O-fucosyltransferases (POFUTs) modifying proteins with elastin microfibril interface (EMI) domains. Curious to know the function(s) of O-fucosylating EMI domains
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adnan Halim
Still time to register to awsome Glycobiology Gordon Research Conference 2025. We have a fantastic line of speakers and this will be top #glycotime in Tuscany !! Register at www.grc.org/glycobiology...
November 17, 2024 at 8:06 PM
Still time to register to awsome Glycobiology Gordon Research Conference 2025. We have a fantastic line of speakers and this will be top #glycotime in Tuscany !! Register at www.grc.org/glycobiology...
Reposted by Adnan Halim
New bit of work from CCG, with our newest cellular framework - GlycoCarrier
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mammalian cell-based production of glycans, glycopeptides and glycomodules - Nature Communications
Access to defined human glycans is crucial for biomedical research. Here, authors report Glycocarriers, a mammalian cell-based method for the sustainable and scalable production of O-, N-glycans, and ...
www.nature.com
November 12, 2024 at 4:39 PM
New bit of work from CCG, with our newest cellular framework - GlycoCarrier
www.nature.com/articles/s41...
www.nature.com/articles/s41...