Bagnat Lab
@bagnatlab.bsky.social
Interested in understanding the role of basic cellular processes in shaping tissues and organs!
Located at Duke University
https://sites.duke.edu/bagnat/
Located at Duke University
https://sites.duke.edu/bagnat/
Pinned
Bagnat Lab
@bagnatlab.bsky.social
· Nov 22
BAGNAT LAB
sites.duke.edu
Hello from the Bagnat Lab! ✨
We’re diving into the mysteries of organ development and physiology using zebrafish as our tiny research heroes 🐠.
Follow us for updates on our discoveries, lab adventures, and the occasional fish pun (because science should make a splash and a smile).
We’re diving into the mysteries of organ development and physiology using zebrafish as our tiny research heroes 🐠.
Follow us for updates on our discoveries, lab adventures, and the occasional fish pun (because science should make a splash and a smile).
Reposted by Bagnat Lab
Now online! Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry is enabled by the unique properties of cholesterol and endows biomembranes with distinctive properties and physiological roles.
dlvr.it
April 2, 2025 at 6:51 PM
Now online! Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
Reposted by Bagnat Lab
Congratulations to Dr. Laura on her hooding ceremony this past weekend! Laura has been an invaluable member of our lab, and we hope the ceremony honored her complex journey to completing her Ph.D.- very well deserved Laura!
#grad2025 #dukeuniversity
#grad2025 #dukeuniversity
May 13, 2025 at 7:09 PM
Congratulations to Dr. Laura on her hooding ceremony this past weekend! Laura has been an invaluable member of our lab, and we hope the ceremony honored her complex journey to completing her Ph.D.- very well deserved Laura!
#grad2025 #dukeuniversity
#grad2025 #dukeuniversity
May 13, 2025 at 6:49 PM
Congratulations to Dr. Laura on her hooding ceremony this past weekend! Laura has been an invaluable member of our lab, and we hope the ceremony honored her complex journey to completing her Ph.D.- very well deserved Laura!
#grad2025 #dukeuniversity
#grad2025 #dukeuniversity
What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues.
www.science.org/doi/10.1126/...
#academiasky
www.science.org/doi/10.1126/...
#academiasky
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 1, 2025 at 6:30 PM
What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues.
www.science.org/doi/10.1126/...
#academiasky
www.science.org/doi/10.1126/...
#academiasky
Exciting paper from our collaborator! Using sophisticated laser ablation studies, Wu et al find that early mitotic events in specific Kupffer’s Vesicle cells are crucial for morphogenesis and lumen formation.
Check it out! doi.org/10.1242/dev....
Check it out! doi.org/10.1242/dev....
Specific mitotic events drive left-right organizer development
Cell proliferation is crucial for tissue development. Here, we investigate its role in the Left-Right Organizer (LRO), which establishes the left-right (LR) axis. In zebrafish, we mapped mitotic event...
doi.org
May 1, 2025 at 6:27 PM
Exciting paper from our collaborator! Using sophisticated laser ablation studies, Wu et al find that early mitotic events in specific Kupffer’s Vesicle cells are crucial for morphogenesis and lumen formation.
Check it out! doi.org/10.1242/dev....
Check it out! doi.org/10.1242/dev....
Reposted by Bagnat Lab
Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...
An optogenetic toolkit for robust activation of FGF, BMP, and Nodal signaling in zebrafish
Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in ...
www.biorxiv.org
April 21, 2025 at 1:47 PM
Happy to share a new preprint from my lab! We characterize the on/off kinetics, light dosage-dependence, and more for a suite of optogenetic signaling activators in zebrafish embryos 💡 www.biorxiv.org/content/10.1...
Wondergrads Claudia (left) and Reed (right) presented at Duke's Undergraduate Research Symposium! Congratulations on some great work!
#scisky #academicsky #undergradresearch
#scisky #academicsky #undergradresearch
April 14, 2025 at 6:33 PM
Wondergrads Claudia (left) and Reed (right) presented at Duke's Undergraduate Research Symposium! Congratulations on some great work!
#scisky #academicsky #undergradresearch
#scisky #academicsky #undergradresearch
Beautiful paper from the Gray lab showing that vacuole expansion in notochord cells is crucial for proper spine formation! Check it out!
pubmed.ncbi.nlm.nih.gov/40209709/
#zebrafish #scisky #academicsky
pubmed.ncbi.nlm.nih.gov/40209709/
#zebrafish #scisky #academicsky
Cell expansion for notochord mechanics and endochondral bone lengthening in zebrafish depends on the 5'-inositol phosphatase Inppl1a - PubMed
Cell size is a key contributor to tissue morphogenesis. As a notable example, growth plate hypertrophic chondrocytes use cellular biogenesis and disproportionate fluid uptake to expand 10 to 20 times ...
pubmed.ncbi.nlm.nih.gov
April 14, 2025 at 3:04 PM
Beautiful paper from the Gray lab showing that vacuole expansion in notochord cells is crucial for proper spine formation! Check it out!
pubmed.ncbi.nlm.nih.gov/40209709/
#zebrafish #scisky #academicsky
pubmed.ncbi.nlm.nih.gov/40209709/
#zebrafish #scisky #academicsky
#HiSciSky #scisky #academicsky #zebrafish
Excited to announce our lab's preprint has been officially published! Discover how gut cells and the microbiome regulate protein absorption in zebrafish!
elifesciences.org/reviewed-pre...
@elife.bsky.social
@zebrafishrock.bsky.social y.social
Excited to announce our lab's preprint has been officially published! Discover how gut cells and the microbiome regulate protein absorption in zebrafish!
elifesciences.org/reviewed-pre...
@elife.bsky.social
@zebrafishrock.bsky.social y.social
Protein absorption in the zebrafish gut is regulated by interactions between lysosome rich enterocytes and the microbiome
elifesciences.org
February 11, 2025 at 5:12 PM
#HiSciSky #scisky #academicsky #zebrafish
Excited to announce our lab's preprint has been officially published! Discover how gut cells and the microbiome regulate protein absorption in zebrafish!
elifesciences.org/reviewed-pre...
@elife.bsky.social
@zebrafishrock.bsky.social y.social
Excited to announce our lab's preprint has been officially published! Discover how gut cells and the microbiome regulate protein absorption in zebrafish!
elifesciences.org/reviewed-pre...
@elife.bsky.social
@zebrafishrock.bsky.social y.social
Holiday party! Nothing fishy here, just good food and great company. (psss. isn't our elf adorable?)
#holidayparty #sciencefun
#holidayparty #sciencefun
December 12, 2024 at 8:08 PM
Holiday party! Nothing fishy here, just good food and great company. (psss. isn't our elf adorable?)
#holidayparty #sciencefun
#holidayparty #sciencefun
#HiSciSky #scisky #academicsky
Excited to share our lab's latest preprint! Discover how gut microbes influence protein absorption in zebrafish.
@elife.bsky.social @zebrafishrock.bsky.social
elifesciences.org/articles/104...
Excited to share our lab's latest preprint! Discover how gut microbes influence protein absorption in zebrafish.
@elife.bsky.social @zebrafishrock.bsky.social
elifesciences.org/articles/104...
Microbiome: Balancing microbial composition through diet
A reciprocal interaction between gut bacteria and gut cells affects protein absorption in the host.
elifesciences.org
December 5, 2024 at 8:04 PM
#HiSciSky #scisky #academicsky
Excited to share our lab's latest preprint! Discover how gut microbes influence protein absorption in zebrafish.
@elife.bsky.social @zebrafishrock.bsky.social
elifesciences.org/articles/104...
Excited to share our lab's latest preprint! Discover how gut microbes influence protein absorption in zebrafish.
@elife.bsky.social @zebrafishrock.bsky.social
elifesciences.org/articles/104...
Hello from the Bagnat Lab! ✨
We’re diving into the mysteries of organ development and physiology using zebrafish as our tiny research heroes 🐠.
Follow us for updates on our discoveries, lab adventures, and the occasional fish pun (because science should make a splash and a smile).
We’re diving into the mysteries of organ development and physiology using zebrafish as our tiny research heroes 🐠.
Follow us for updates on our discoveries, lab adventures, and the occasional fish pun (because science should make a splash and a smile).
BAGNAT LAB
sites.duke.edu
November 22, 2024 at 5:36 PM
Hello from the Bagnat Lab! ✨
We’re diving into the mysteries of organ development and physiology using zebrafish as our tiny research heroes 🐠.
Follow us for updates on our discoveries, lab adventures, and the occasional fish pun (because science should make a splash and a smile).
We’re diving into the mysteries of organ development and physiology using zebrafish as our tiny research heroes 🐠.
Follow us for updates on our discoveries, lab adventures, and the occasional fish pun (because science should make a splash and a smile).