We found that ECM ligands and mechanics distinctly regulate fibroblast behavior. And ligands outweigh mechanics in dictating fibroblast activation and rejuvenation. We also predicted ECM- vs biophysical-therapy efficacy with DECIPHER. It’s applicable to other tissue/disease.

DECIPHER: DECellularized In situ Polyacrylamide Hydrogel—Ecm hybRid, enabling independent stiffness tunability while maintaining native ECM composition, architecture, and tissue viscoelasticity, perfect for seeding cells afterwards.

And our lab @jennyoung.bsky.social happens to know enough about polyacrylamide from Engler’s work that we might be able to decouple substrate stiffness in the meantime by controlling the hydrogel recipe ⁉️

DECIPHER: DECellularized In situ Polyacrylamide Hydrogel—Ecm hybRid, enabling independent stiffness tunability while maintaining native ECM composition, architecture, and tissue viscoelasticity, perfect for seeding cells afterwards.

And our lab @jennyoung.bsky.social happens to know enough about polyacrylamide from Engler’s work that we might be able to decouple substrate stiffness in the meantime by controlling the hydrogel recipe ⁉️

Excited for the opportunity to present our research @mbisg.bsky.social on FLiMB Seminar hosted by University of Pennsylvania @upenn.edu ! Thank you the organizers for the invitation and everyone is welcomed to join ⬇️ Thursday at 12am SGT😉