auwerx-lab.bsky.social
@auwerx-lab.bsky.social
The new standards for indirect calorimetry are published. Our lab contributed to an international consortium in defining them.
www.nature.com/articles/s42...
A consensus guide to preclinical indirect calorimetry experiments - Nature Metabolism
The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose harmonization of standards to facilitate data comparison and interpretation across different datasets.
www.nature.com
September 29, 2025 at 9:47 AM
Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, and demonstrate their therapeutic potential in C. elegans and mouse models. @nataging.nature.com. www.nature.com/articles/s43...
Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging - Nature Aging
Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.
www.nature.com
September 29, 2025 at 9:43 AM
Congrats to the Terytty, @arwengao.bsky.social and colleagues for identifying the importance of Lysosomal Surveillance Response (LysR) in fighting age-related protein accumulation. news.epfl.ch/news/a-recyc...
www.nature.com/articles/s41...
A recycling mechanism that helps cells fight aging
An international team led by EPFL has discovered a powerful anti-aging pathway in roundworms, revealing how boosting the cell’s lysosomes can help clear waste and promote healthy aging. The findings o...
news.epfl.ch
July 3, 2025 at 2:03 PM
Johan Auwerx is featured in a piece on investing in the longevity economy. www.swissinfo.ch/eng/healthca...
Can Saudi Arabia’s billions unlock the secrets to a longer, healthier life?
Longevity has been an underfunded area of biotech research but that is changing thanks to an unlikely source: Saudi Arabia.
www.swissinfo.ch
July 3, 2025 at 2:01 PM
An interesting publication on #biotherapeutics to restore the compromised #bileacid signaling in ulcerative colitis! check it out! actu.epfl.ch/news/gut-bac...
Gut bacteria heal the colon
EPFL scientists have uncovered how a gut bacterium, Clostridium scindens, aids in healing intestinal injuries by restoring bile acid balance. Their findings could pave the way for new treatments for u...
actu.epfl.ch
March 17, 2025 at 12:25 PM
The 2025 Health & Demography Conference is now open for virtual registration!
Longevity is reshaping societies and challenging long-standing norms. Join us as we discuss what is needed to thrive in an era of 100-year lives.
Register for virtual participation here: lnkd.in/dAS9viza
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lnkd.in
February 11, 2025 at 2:42 PM
Another step in bringing ceramide lowering therapies to patients with muscle disease. Congratulations to Johanne, Ioanna, and Tanes for your valuable contributions.
pubs.acs.org/doi/10.1021/...
Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia
The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide de...
pubs.acs.org
December 29, 2024 at 4:02 PM
We were selected again as a “Highly Cited Researcher” in 2024 by Clarivate. Thanks to all graduates for the hard work that enabled our continued success!
actu.epfl.ch/news/four-ep...
Four EPFL Professors Among Clarivate's Highly Cited Researchers
Andrea Ablasser, Johan Auwerx, Gioele La Manno and Matthias Lutolf, four professors at EPFL’s School of Life Sciences, have been included in the prestigious list of most Highly Cited Researchers in 20...
actu.epfl.ch
November 29, 2024 at 10:30 AM