Aurélien Doucet
@aurelien-doucet.bsky.social
CNRS researcher at IRCAN (Nice, France) Université Cote d'Azur (UniCA) - Interested in retrotransposons, mobile DNA, transposable elements and jumping genes
Reposted by Aurélien Doucet
TE x ZFP = Evolution!
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
November 18, 2025 at 3:16 PM
TE x ZFP = Evolution!
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Reposted by Aurélien Doucet
📖 Les filles sont parfaites pour les sciences, un ouvrage qui met en lumière des chercheuses, ingénieures et techniciennes.
👩🔬 48 femmes, 48 parcours, une même passion : la science.
Très fière de faire partie de cette belle aventure 💛
📘 En librairie le 15/10
👉 www.editionsmkf.com/femmes-et-sc...
1/2
👩🔬 48 femmes, 48 parcours, une même passion : la science.
Très fière de faire partie de cette belle aventure 💛
📘 En librairie le 15/10
👉 www.editionsmkf.com/femmes-et-sc...
1/2
October 14, 2025 at 8:53 AM
📖 Les filles sont parfaites pour les sciences, un ouvrage qui met en lumière des chercheuses, ingénieures et techniciennes.
👩🔬 48 femmes, 48 parcours, une même passion : la science.
Très fière de faire partie de cette belle aventure 💛
📘 En librairie le 15/10
👉 www.editionsmkf.com/femmes-et-sc...
1/2
👩🔬 48 femmes, 48 parcours, une même passion : la science.
Très fière de faire partie de cette belle aventure 💛
📘 En librairie le 15/10
👉 www.editionsmkf.com/femmes-et-sc...
1/2
Reposted by Aurélien Doucet
🔥 Mark the date! 🗓️
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Pathogen Immunity and Signalling
Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…
meetings.embo.org
October 7, 2025 at 2:48 PM
🔥 Mark the date! 🗓️
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.
Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.
Submit your abstract.
Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
Reposted by Aurélien Doucet
Join IGMM ! 🧬
Postdoctoral Fellow in Oncogenesis.
Apply now 👉 emploi.cnrs.fr/Offres/CDD/U...
#Postdoc #OncologyResearch #ScienceJobs #IGMM #CNRS
Postdoctoral Fellow in Oncogenesis.
Apply now 👉 emploi.cnrs.fr/Offres/CDD/U...
#Postdoc #OncologyResearch #ScienceJobs #IGMM #CNRS
Portail Emploi CNRS - Offre d'emploi - Postdoctoral fellow in oncogenesis (M/F)
emploi.cnrs.fr
September 23, 2025 at 9:11 AM
Join IGMM ! 🧬
Postdoctoral Fellow in Oncogenesis.
Apply now 👉 emploi.cnrs.fr/Offres/CDD/U...
#Postdoc #OncologyResearch #ScienceJobs #IGMM #CNRS
Postdoctoral Fellow in Oncogenesis.
Apply now 👉 emploi.cnrs.fr/Offres/CDD/U...
#Postdoc #OncologyResearch #ScienceJobs #IGMM #CNRS
Reposted by Aurélien Doucet
Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below!
doi.org/10.1126/scie...
doi.org/10.1126/scie...
Transposable elements are vectors of recurrent transgenerational epigenetic inheritance
DNA methylation loss at transposable elements (TEs) can affect neighboring genes and be epigenetically inherited in plants, yet the determinants and significance of this additional system of inheritan...
doi.org
September 18, 2025 at 6:35 PM
Happy to share the results of a long-haul post-doc project, now online @science.org, aiming at understanding the rules of transgeneration epigenetic inheritance over TEs in plants and its extent and impact in nature. More below!
doi.org/10.1126/scie...
doi.org/10.1126/scie...
Reposted by Aurélien Doucet
Hi! We are looking for a PhD to work on the cross talk between transposable elements, insects and intracellular bacteria on the bioinformatics side. The PhD would be supervised by @mariefablet.bsky.social and myself along with @nicolasparisot.bsky.social Deadline December 2025! Please share! #tesky
September 16, 2025 at 6:13 AM
Hi! We are looking for a PhD to work on the cross talk between transposable elements, insects and intracellular bacteria on the bioinformatics side. The PhD would be supervised by @mariefablet.bsky.social and myself along with @nicolasparisot.bsky.social Deadline December 2025! Please share! #tesky
Reposted by Aurélien Doucet
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...
hematopoiesis. www.cell.com/trends/cance...
Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis
Retrotransposons are mobile repetitive elements that constitute around 43% of the
human genome. Normally silenced through epigenetic mechanisms, retrotransposons can
become reactivated in response to ...
www.cell.com
September 3, 2025 at 5:02 AM
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...
hematopoiesis. www.cell.com/trends/cance...
Reposted by Aurélien Doucet
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 9:47 AM
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Reposted by Aurélien Doucet
🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics
July 11, 2025 at 9:43 PM
🦟 Bioinformatics Research Scientist position open in my lab in Nice (FR) to study Aedes mosquito retrotransposons & their interactions with arboviruses collab w/ @salehlabparis.bsky.social & @lambrechtslab.bsky.social
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics
Apply: euraxess.ec.europa.eu/jobs/359830
Please boost! #ArboRetro #Bioinformatics
Reposted by Aurélien Doucet
Have you ever wanted to design large and complex ribozymes from scratch? I know I have!
We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!
#intron #RNAsky #SynBio 🧬🧵(1/n)
We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!
#intron #RNAsky #SynBio 🧬🧵(1/n)
Computational De Novo Design of Group II Introns Yields Highly Active Ribozymes
Group II Introns (G2Is) are large self-splicing ribozymes with promising biotechnological applications. This study utilized RNA inverse folding to design three novel G2Is. The designed intron Arq.I2,...
doi.org
July 2, 2025 at 10:01 AM
Have you ever wanted to design large and complex ribozymes from scratch? I know I have!
We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!
#intron #RNAsky #SynBio 🧬🧵(1/n)
We used RNA inverse folding to design synthetic Group II Introns (G2Is) from the bottom up, resulting in highly active #ribozymes that splice in E. coli without proteins!
#intron #RNAsky #SynBio 🧬🧵(1/n)
Reposted by Aurélien Doucet
🌊 Tout le mois de juin, dans le cadre de l'Année de la Mer et en marge de l' #UNOC3, retrouvez la très belle exposition du @cnrs.fr "L'océan si fort et si fragile" sur la Promenade de l'Octroi à Villefranche-sur-Mer !
Les experts décryptent ce monde bleu, clé de l’équilibre de notre planète 🌎
Les experts décryptent ce monde bleu, clé de l’équilibre de notre planète 🌎
June 10, 2025 at 2:03 PM
Reposted by Aurélien Doucet
Ce 22 mai, le campus Valrose d’Université Côte d’Azur a accueilli plus de 500 élèves issus de 25 classes de collèges et lycées pour la grande restitution de fin d’année des projets scolaires "Science et Société".
Une journée placée sous le signe de la curiosité scientifique et de la créativité !
Une journée placée sous le signe de la curiosité scientifique et de la créativité !
May 22, 2025 at 2:07 PM
Ce 22 mai, le campus Valrose d’Université Côte d’Azur a accueilli plus de 500 élèves issus de 25 classes de collèges et lycées pour la grande restitution de fin d’année des projets scolaires "Science et Société".
Une journée placée sous le signe de la curiosité scientifique et de la créativité !
Une journée placée sous le signe de la curiosité scientifique et de la créativité !
Reposted by Aurélien Doucet
Our paper is now published in its final form: rdcu.be/elV6u @biomedcentral.bsky.social @salehlabparis.bsky.social @merklinglab.bsky.social @pasteur.fr
May 15, 2025 at 6:57 AM
Our paper is now published in its final form: rdcu.be/elV6u @biomedcentral.bsky.social @salehlabparis.bsky.social @merklinglab.bsky.social @pasteur.fr
Reposted by Aurélien Doucet
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 10:45 AM
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Reposted by Aurélien Doucet
Reposted by Aurélien Doucet
Interested in the analysis on Transposable elements? 🧬
Have a look at our course with @valentinapeona.bsky.social & @ritarebollo.bsky.social
We'll cover everything from TE biology to de novo library construction, quantification, & transcriptomic analysis.
www.physalia-courses.org/courses-work...
Have a look at our course with @valentinapeona.bsky.social & @ritarebollo.bsky.social
We'll cover everything from TE biology to de novo library construction, quantification, & transcriptomic analysis.
www.physalia-courses.org/courses-work...
April 23, 2025 at 1:12 PM
Interested in the analysis on Transposable elements? 🧬
Have a look at our course with @valentinapeona.bsky.social & @ritarebollo.bsky.social
We'll cover everything from TE biology to de novo library construction, quantification, & transcriptomic analysis.
www.physalia-courses.org/courses-work...
Have a look at our course with @valentinapeona.bsky.social & @ritarebollo.bsky.social
We'll cover everything from TE biology to de novo library construction, quantification, & transcriptomic analysis.
www.physalia-courses.org/courses-work...
Reposted by Aurélien Doucet
Fantastic talk by @aktast.bsky.social unraveling how RNA binding proteins tame the TE transcriptome, control their exonization and allow for the peaceful co-existence of TE and host genes.
LOVE IT. #TECSHA
LOVE IT. #TECSHA
April 9, 2025 at 1:23 AM
Fantastic talk by @aktast.bsky.social unraveling how RNA binding proteins tame the TE transcriptome, control their exonization and allow for the peaceful co-existence of TE and host genes.
LOVE IT. #TECSHA
LOVE IT. #TECSHA
Reposted by Aurélien Doucet
Great talk by @emiliebrasset.bsky.social at #TECSHA on the regulation of piRNA production in germline vs somatic compartments of Drosophila ovary. Sophisticated mechanisms have evolved to control different sets of TEs, to the benefit (I think) of both host and TEs.
April 8, 2025 at 1:37 AM
Great talk by @emiliebrasset.bsky.social at #TECSHA on the regulation of piRNA production in germline vs somatic compartments of Drosophila ovary. Sophisticated mechanisms have evolved to control different sets of TEs, to the benefit (I think) of both host and TEs.
Reposted by Aurélien Doucet
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
tinyurl.com/PostdocEvoEp...
Repost are appreciated
March 31, 2025 at 1:26 PM
Hello World! Are you passionate about epigenomics and evolution 🧪🧬🐭🐵 ? Are you looking for a postdoc in a stimulating and inclusive environment ? Look no further... We are seeking creative postdocs for our ERC project EvoEpi @igred.fr ! 👇Details👇
tinyurl.com/PostdocEvoEp...
Repost are appreciated
tinyurl.com/PostdocEvoEp...
Repost are appreciated
Reposted by Aurélien Doucet
Un scientifique utilise la chimie pour créer des œuvres d'art visuelles époustouflantes. En combinant différents éléments et réactions chimiques, il produit des images fascinantes dans une goutte d'eau 💧!
March 30, 2025 at 3:08 PM
Un scientifique utilise la chimie pour créer des œuvres d'art visuelles époustouflantes. En combinant différents éléments et réactions chimiques, il produit des images fascinantes dans une goutte d'eau 💧!
Reposted by Aurélien Doucet
Our study with Anjana Rao's lab was just published at NSMB 🥳 Shows how OGT prevents TET proteins from activating retrotransposons, particularly those in heterochromatin. Paper has 6-base and ONT sequencing data from OGT iKO mESCs, and also interesting OGT inhibitor data 👀.
rdcu.be/efuho
rdcu.be/efuho
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide
Nature Structural & Molecular Biology - Here the authors show that the disruption of OGT expression in mouse embryonic stem cells unleashes TET activity, causing genome-wide decreases in DNA...
rdcu.be
March 28, 2025 at 11:43 AM
Our study with Anjana Rao's lab was just published at NSMB 🥳 Shows how OGT prevents TET proteins from activating retrotransposons, particularly those in heterochromatin. Paper has 6-base and ONT sequencing data from OGT iKO mESCs, and also interesting OGT inhibitor data 👀.
rdcu.be/efuho
rdcu.be/efuho
Reposted by Aurélien Doucet
Le mot du mois #Recherche 📚
Les travaux sur les gênes sauteurs offrent de nouvelles perspectives sur l'évolution et la génétique humaine, avec des applications potentielles pour le diagnostic et le traitement des cancers.
swll.to/genessauteurs
@insermpacacorse.bsky.social
Les travaux sur les gênes sauteurs offrent de nouvelles perspectives sur l'évolution et la génétique humaine, avec des applications potentielles pour le diagnostic et le traitement des cancers.
swll.to/genessauteurs
@insermpacacorse.bsky.social
March 27, 2025 at 4:24 PM
Le mot du mois #Recherche 📚
Les travaux sur les gênes sauteurs offrent de nouvelles perspectives sur l'évolution et la génétique humaine, avec des applications potentielles pour le diagnostic et le traitement des cancers.
swll.to/genessauteurs
@insermpacacorse.bsky.social
Les travaux sur les gênes sauteurs offrent de nouvelles perspectives sur l'évolution et la génétique humaine, avec des applications potentielles pour le diagnostic et le traitement des cancers.
swll.to/genessauteurs
@insermpacacorse.bsky.social
Reposted by Aurélien Doucet
Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects
Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2
academic.oup.com
March 27, 2025 at 10:13 AM
Our latest paper is out in NAR! 🥳
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates.
Read:
academic.oup.com/nar/article-...
Reposted by Aurélien Doucet
🧑🔬 Moins de bruit, plus de Science !
Tous les 15 jours, explorez la science autrement avec nos chefs de rubrique @bentonson.bsky.social et Elsa Couderc : découvertes inédites, nouvelles voix, décryptages exclusifs et bien plus encore.
⭐️ Abonnez-vous gratuitement : urlr.me/bnsS7G
Tous les 15 jours, explorez la science autrement avec nos chefs de rubrique @bentonson.bsky.social et Elsa Couderc : découvertes inédites, nouvelles voix, décryptages exclusifs et bien plus encore.
⭐️ Abonnez-vous gratuitement : urlr.me/bnsS7G
March 19, 2025 at 2:02 PM
🧑🔬 Moins de bruit, plus de Science !
Tous les 15 jours, explorez la science autrement avec nos chefs de rubrique @bentonson.bsky.social et Elsa Couderc : découvertes inédites, nouvelles voix, décryptages exclusifs et bien plus encore.
⭐️ Abonnez-vous gratuitement : urlr.me/bnsS7G
Tous les 15 jours, explorez la science autrement avec nos chefs de rubrique @bentonson.bsky.social et Elsa Couderc : découvertes inédites, nouvelles voix, décryptages exclusifs et bien plus encore.
⭐️ Abonnez-vous gratuitement : urlr.me/bnsS7G