Auclair Lab
@auclairlab.bsky.social
We explore many fields of chemistry and biology (many of them concerning enzymes).
Located at McGill University, Montreal.
Student-ran account: posts not by Dr. Auclair unless indicated.
RP/follow ≠ endorsement.
https://www.auclair-group.mcgill.ca
Located at McGill University, Montreal.
Student-ran account: posts not by Dr. Auclair unless indicated.
RP/follow ≠ endorsement.
https://www.auclair-group.mcgill.ca
From the Auclair lab: Dr. Jacob Pierscianowski, Dr. Dustin Duncan, Dr. Blue Lan, Dr. Rohit Kholiya, Suzana Diaconescu-Grabari, Ahmed B. Abdelaal, Aracelli Chang, Shay Heans, Dr. Sanjay Campbell, Dr. Alexandre Pierret.
With collaboration from the groups of Profs. Schmeing, Findlay, and Lupien.
With collaboration from the groups of Profs. Schmeing, Findlay, and Lupien.
October 30, 2025 at 7:54 PM
From the Auclair lab: Dr. Jacob Pierscianowski, Dr. Dustin Duncan, Dr. Blue Lan, Dr. Rohit Kholiya, Suzana Diaconescu-Grabari, Ahmed B. Abdelaal, Aracelli Chang, Shay Heans, Dr. Sanjay Campbell, Dr. Alexandre Pierret.
With collaboration from the groups of Profs. Schmeing, Findlay, and Lupien.
With collaboration from the groups of Profs. Schmeing, Findlay, and Lupien.
- Our pantothenamide mimics avoid degradation by pantetheinases thanks to the bond substitution
- Sub-micromolar antiplasmodial activity in vitro
- Excellent selectivity for plasmodial enzymes vs. human enzymes
- Computational analysis included to gain insight into SARs
- Sub-micromolar antiplasmodial activity in vitro
- Excellent selectivity for plasmodial enzymes vs. human enzymes
- Computational analysis included to gain insight into SARs
August 13, 2025 at 5:10 PM
- Our pantothenamide mimics avoid degradation by pantetheinases thanks to the bond substitution
- Sub-micromolar antiplasmodial activity in vitro
- Excellent selectivity for plasmodial enzymes vs. human enzymes
- Computational analysis included to gain insight into SARs
- Sub-micromolar antiplasmodial activity in vitro
- Excellent selectivity for plasmodial enzymes vs. human enzymes
- Computational analysis included to gain insight into SARs
Key notes:
- Made possible by Annica Chu, Dr. Mina Nekouei, Dr. Blue Lan, and Dr. Alexandre Pierret of the Auclair lab, in collaboration with Xiangning Liu from the group of Prof. Kevin J. Saliba
- These molecules follow the parasite CoA pathway and become potent, low-cytotoxicity antimetabolites
- Made possible by Annica Chu, Dr. Mina Nekouei, Dr. Blue Lan, and Dr. Alexandre Pierret of the Auclair lab, in collaboration with Xiangning Liu from the group of Prof. Kevin J. Saliba
- These molecules follow the parasite CoA pathway and become potent, low-cytotoxicity antimetabolites
August 13, 2025 at 5:10 PM
Key notes:
- Made possible by Annica Chu, Dr. Mina Nekouei, Dr. Blue Lan, and Dr. Alexandre Pierret of the Auclair lab, in collaboration with Xiangning Liu from the group of Prof. Kevin J. Saliba
- These molecules follow the parasite CoA pathway and become potent, low-cytotoxicity antimetabolites
- Made possible by Annica Chu, Dr. Mina Nekouei, Dr. Blue Lan, and Dr. Alexandre Pierret of the Auclair lab, in collaboration with Xiangning Liu from the group of Prof. Kevin J. Saliba
- These molecules follow the parasite CoA pathway and become potent, low-cytotoxicity antimetabolites