Mark Fiers
@ataraxia42.bsky.social
Reposted by Mark Fiers
Reposted by Mark Fiers
How do we capture discrepancies between the biology of human tissues and experimental models? And what can we do to reduce this "translational distance"? A multiscale systems biology framework can be used to study disease mechanisms at a given spatiotemporal scale.
New online! Adapting systems biology to address the complexity of human disease in the single-cell era
Adapting systems biology to address the complexity of human disease in the single-cell era
Nature Reviews Genetics, Published online: 10 March 2025; doi:10.1038/s41576-025-00821-6Differences between humans and experimental models create a translational gap that makes it difficult to extrapolate research findings. The authors review…
www.nature.com
March 10, 2025 at 12:43 PM
How do we capture discrepancies between the biology of human tissues and experimental models? And what can we do to reduce this "translational distance"? A multiscale systems biology framework can be used to study disease mechanisms at a given spatiotemporal scale.
Reposted by Mark Fiers
Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...
A cell atlas foundation model for scalable search of similar human cells - Nature
Nature - A cell atlas foundation model for scalable search of similar human cells
www.nature.com
November 22, 2024 at 10:34 PM
Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...