This study presents the first evidence of single-stranded DNA (ssDNA) sequences identified through shotgun metagenomic analysis of meteorite-derived cultures. These ssDNA sequences, predominantly isol...

More than three billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here we show that language models trained at scale on evolutionary data can gen...

Engineered kill-switch-encoding Mycobacterium tuberculosis infects, elicits immune responses and is cleared from immunocompetent and immunocompromised mice, providing a model of controlled tuberculosi...

Hyde et al. found elevated HSV-1 protein expression in Alzheimer’s disease, with phosphorylated tau strongly colocalizing with HSV-1 proteins. They demonstrated that tau phosphorylation responds to HSV-1 via the innate immune cGAS-STING pathway, reducing HSV-1 protein expression and increasing neuronal viability, highlighting a role for tau phosphorylation in innate immunity.