Armin Töpfer
@armintoepfer.com
Husband. Parent. Dr sc @ETH. Bioinformagician. Father of @PacBio HiFi. C++ Purist. Geek. Digital Artist. Electronic music. Speaks in memes. Opinions are my own!
What's going on in #bioinformatics? Any new cool alignment or mapping algos? Any advances in kmer hashing?
November 1, 2025 at 7:51 PM
What's going on in #bioinformatics? Any new cool alignment or mapping algos? Any advances in kmer hashing?
When a candidate's CV matches the job description too well
October 19, 2025 at 2:05 PM
When a candidate's CV matches the job description too well
No updates from my side today
October 18, 2025 at 7:49 PM
No updates from my side today
No updates from my side today.
July 22, 2025 at 3:23 PM
No updates from my side today.
I've been unhappy with my Sonos equipment. Last night, I've decided to take things into my own hands and created a local sonos controller in the browser with LLM help. Once I grok the full API, final frontier will be an Android app. Everything is 100% open source github.com/armintoepfer...
February 16, 2025 at 9:51 PM
I've been unhappy with my Sonos equipment. Last night, I've decided to take things into my own hands and created a local sonos controller in the browser with LLM help. Once I grok the full API, final frontier will be an Android app. Everything is 100% open source github.com/armintoepfer...
Back in town, this time staying a few nights in SF. Good to be back and looking forward to meeting y'all @pacbio.bsky.social
January 16, 2025 at 2:20 AM
Back in town, this time staying a few nights in SF. Good to be back and looking forward to meeting y'all @pacbio.bsky.social
I wonder if someone will sit down and write a better map-and-align tool than minimap2. If yes, will it (I) still support crappy 90% accuracy long reads or not and (II) offer interoperability being written in C or C++?
December 4, 2024 at 9:49 PM
I wonder if someone will sit down and write a better map-and-align tool than minimap2. If yes, will it (I) still support crappy 90% accuracy long reads or not and (II) offer interoperability being written in C or C++?
North German breakfast
December 3, 2024 at 12:09 PM
North German breakfast
Advent of code, hardcore edition
Day A:
Write fizz buzz in Haskell. You need to create a new DSL. You can only use letters of {A,C,G,T}. The code must be stored in DNA. You need to sequence and assemble it. Maximum coverage of 3-fold. Implicit error correction is allowed.
Hint:
Use HiFi.
Day A:
Write fizz buzz in Haskell. You need to create a new DSL. You can only use letters of {A,C,G,T}. The code must be stored in DNA. You need to sequence and assemble it. Maximum coverage of 3-fold. Implicit error correction is allowed.
Hint:
Use HiFi.
December 3, 2024 at 1:54 AM
Advent of code, hardcore edition
Day A:
Write fizz buzz in Haskell. You need to create a new DSL. You can only use letters of {A,C,G,T}. The code must be stored in DNA. You need to sequence and assemble it. Maximum coverage of 3-fold. Implicit error correction is allowed.
Hint:
Use HiFi.
Day A:
Write fizz buzz in Haskell. You need to create a new DSL. You can only use letters of {A,C,G,T}. The code must be stored in DNA. You need to sequence and assemble it. Maximum coverage of 3-fold. Implicit error correction is allowed.
Hint:
Use HiFi.
There's no traffic jam on the extra mile
December 2, 2024 at 9:10 AM
There's no traffic jam on the extra mile
Things that happen if you spawn uint -1 threads on MacOS. The system instantly freezes and reboots after like 10 seconds.
November 30, 2024 at 9:30 AM
Things that happen if you spawn uint -1 threads on MacOS. The system instantly freezes and reboots after like 10 seconds.
Performance review time of the year
November 29, 2024 at 10:20 PM
Performance review time of the year
Trying out the new QwQ to rewrite gepard:
Step 12: Think about parallelization for speed.
- Given the large size of the sequence, parallel processing will be essential.
- C++ allows for multi-threading, but for更大规模的并行，可以考虑使用GPGPU CUDA。
- 如果能够将计算分解为可以在GPU上并行执行的小任务，那么CUDA将是一个很好的选择。
...yeah
Step 12: Think about parallelization for speed.
- Given the large size of the sequence, parallel processing will be essential.
- C++ allows for multi-threading, but for更大规模的并行，可以考虑使用GPGPU CUDA。
- 如果能够将计算分解为可以在GPU上并行执行的小任务，那么CUDA将是一个很好的选择。
...yeah
November 29, 2024 at 8:04 AM
Trying out the new QwQ to rewrite gepard:
Step 12: Think about parallelization for speed.
- Given the large size of the sequence, parallel processing will be essential.
- C++ allows for multi-threading, but for更大规模的并行，可以考虑使用GPGPU CUDA。
- 如果能够将计算分解为可以在GPU上并行执行的小任务，那么CUDA将是一个很好的选择。
...yeah
Step 12: Think about parallelization for speed.
- Given the large size of the sequence, parallel processing will be essential.
- C++ allows for multi-threading, but for更大规模的并行，可以考虑使用GPGPU CUDA。
- 如果能够将计算分解为可以在GPU上并行执行的小任务，那么CUDA将是一个很好的选择。
...yeah
Just changed my handle to @armintoepfer.com pretty sweet feature
November 28, 2024 at 7:06 PM
Just changed my handle to @armintoepfer.com pretty sweet feature
I'm not used to having a normal work day from 8-4. Thanksgiving break shows me the real European work life balance that I get once per year.
Usually I have 3-5 meetings between 5-9pm, 10 ppl pinging me on slack, verification churn, and chain of command asking me for updates.
Usually I have 3-5 meetings between 5-9pm, 10 ppl pinging me on slack, verification churn, and chain of command asking me for updates.
November 28, 2024 at 6:51 PM
I'm not used to having a normal work day from 8-4. Thanksgiving break shows me the real European work life balance that I get once per year.
Usually I have 3-5 meetings between 5-9pm, 10 ppl pinging me on slack, verification churn, and chain of command asking me for updates.
Usually I have 3-5 meetings between 5-9pm, 10 ppl pinging me on slack, verification churn, and chain of command asking me for updates.
AI will help the ambitious to become more productive and successful.
But you need to have a solid background to innovate, hands-on experience to make things really fast, must have suffered to grow, and be able to articulate and explain a hard problem.
I need you to build the nexgen #PacBio. Apply
But you need to have a solid background to innovate, hands-on experience to make things really fast, must have suffered to grow, and be able to articulate and explain a hard problem.
I need you to build the nexgen #PacBio. Apply
November 24, 2024 at 9:50 PM
AI will help the ambitious to become more productive and successful.
But you need to have a solid background to innovate, hands-on experience to make things really fast, must have suffered to grow, and be able to articulate and explain a hard problem.
I need you to build the nexgen #PacBio. Apply
But you need to have a solid background to innovate, hands-on experience to make things really fast, must have suffered to grow, and be able to articulate and explain a hard problem.
I need you to build the nexgen #PacBio. Apply
Tis the season, baking with the kids
November 24, 2024 at 9:27 PM
Tis the season, baking with the kids
Tired of chasing streaming providers, I just got this gem, forever.
November 23, 2024 at 7:27 PM
Tired of chasing streaming providers, I just got this gem, forever.
I made fried rice. Uncle Roger would approve.
November 22, 2024 at 4:53 PM
I made fried rice. Uncle Roger would approve.
True leadership recognizes the unseen effort that prevents chaos — humility begins with appreciating the fires that never had to be fought.
November 20, 2024 at 11:35 PM
True leadership recognizes the unseen effort that prevents chaos — humility begins with appreciating the fires that never had to be fought.
