Among many things, in this episode we discuss:
- Obsidian's lead program, OBX-115, a modified TIL cell therapy
- The critical role of TCR sequencing in profiling infusion products, tracking clonotypes, and identifying biomarkers for therapy response.

Listen/View here:
youtu.be/J41q0fUqeVo?...

For those of you who are trying to digest the recently released ESMO 2025 abstracts, abstract.plus now runs a web tool that helps you filter/annotate abstracts with a few clicks.

Here is my second vibe coding experiment:

github.com/armish/prism...

a Python package (with a CLI) that can extract embedded @GraphPad PRISM plots from @powerpoint slides and insert them back.

Inspired by fastapi-mcp package, I (vibe-) coded {plumber2mcp}, a simple package to help add MCP support to a {plumber} API:

#rstats
pr('plumber.R') %>%
pr_mcp(transport='stdio') %>%
pr_run(port = 8000)

Supports HTTP/STDIO, tool/resource definitions, and schemas

It is so hard to browse, narrow, and annotate big conference (e.g. #ASCO25) abstracts using their original web sites. For the last 1.5 years, I have been experimenting with an AI-assisted way to consume these materials. I finally was able to combine my scripts into a single web application.

AlphaFold folks: is there a place where I can batch download MSAs (.a3m files) of the human proteome? Re-running mmseq2 on all the human proteins sounds like it would be a waste of time/resources?

For those of you who want to play with an HGNC-savvy GPT for mundane gene ID mapping/look-up tasks, I present you Hugo the GPT: chat.openai.com/g/g-E7GrLSwn...

#AppleEvent 👏 Biomedical researchers 👏QuPath 👏 MinKNOW 👏