Arjun Raj
@arjunraj.bsky.social
Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. http://rajlab.seas.upenn.edu https://rajlaboratory.blogspot.com
Reposted by Arjun Raj
Huh, that new paper looks cool! Although in our paper, we found that it was transcriptional burst size that changed with volume, not burst fraction. Here, they seem to find burst fraction. Admittedly, their technique is probably better suited to make the distinction. Interesting!
November 5, 2025 at 10:41 AM
Huh, that new paper looks cool! Although in our paper, we found that it was transcriptional burst size that changed with volume, not burst fraction. Here, they seem to find burst fraction. Admittedly, their technique is probably better suited to make the distinction. Interesting!
Reposted by Arjun Raj
But @arjunraj.bsky.social showed similar results 10 yrs ago.
What's new in this paper?
www.cell.com/molecular-ce...
What's new in this paper?
www.cell.com/molecular-ce...
Single Mammalian Cells Compensate for Differences in Cellular Volume and DNA Copy Number through Independent Global Transcriptional Mechanisms
Padovan-Merhar et al. combine single-molecule transcript counting with computational
measurement of cellular volume, showing that single cells maintain transcript abundance
despite variability in cell...
www.cell.com
November 2, 2025 at 8:18 PM
But @arjunraj.bsky.social showed similar results 10 yrs ago.
What's new in this paper?
www.cell.com/molecular-ce...
What's new in this paper?
www.cell.com/molecular-ce...
Huh, that new paper looks cool! Although in our paper, we found that it was transcriptional burst size that changed with volume, not burst fraction. Here, they seem to find burst fraction. Admittedly, their technique is probably better suited to make the distinction. Interesting!
November 5, 2025 at 10:41 AM
Huh, that new paper looks cool! Although in our paper, we found that it was transcriptional burst size that changed with volume, not burst fraction. Here, they seem to find burst fraction. Admittedly, their technique is probably better suited to make the distinction. Interesting!
Yes. The one thing I truly can’t understand is why nobody even wants to try something new, even just a little bit. Witness the fracas over the relatively modest innovations proposed by eLife. You are so right—our insistence on consensus has created a situation where all innovation is snuffed out.
October 6, 2025 at 10:09 AM
Yes. The one thing I truly can’t understand is why nobody even wants to try something new, even just a little bit. Witness the fracas over the relatively modest innovations proposed by eLife. You are so right—our insistence on consensus has created a situation where all innovation is snuffed out.
Various delays, hopefully out soon!
September 27, 2025 at 3:00 PM
Various delays, hopefully out soon!
Reposted by Arjun Raj
sounds interesting and i look forward to reading it! from the abstract it reminds me of an old paper P. Bousso's group had on T cells; I always thought the finding was fascinating: journals.plos.org/plosone/arti...
A Role for the Immediate Early Gene Product c-fos in Imprinting T Cells with Short-Term Memory for Signal Summation
T cells often make sequential contacts with multiple DCs in the lymph nodes and are likely to be equipped with mechanisms that allow them to sum up the successive signals received. We found that a per...
journals.plos.org
September 26, 2025 at 12:47 PM
sounds interesting and i look forward to reading it! from the abstract it reminds me of an old paper P. Bousso's group had on T cells; I always thought the finding was fascinating: journals.plos.org/plosone/arti...
Entirely self-serving :), but here's one of my favorite papers from the lab, which I think you might enjoy: www.biorxiv.org/content/10.1...
AP-1 Mediates Cellular Adaptation and Memory Formation During Therapy Resistance
Cellular responses to environmental stimuli are typically thought to be governed by genetically encoded programs. We demonstrate that melanoma cells can form and maintain cellular memories during the ...
www.biorxiv.org
September 26, 2025 at 11:41 AM
Entirely self-serving :), but here's one of my favorite papers from the lab, which I think you might enjoy: www.biorxiv.org/content/10.1...