Abdel Rahman Abdel Fattah
@ar-abdelfattah.bsky.social
Principal Investigator - CeMM Research Center for Molecular Medicine
Bioengineer - We use tools to investigate ECM-metabolic-morphogenesis interplay to explore how tissues initiate, maintain and lose organization
Bioengineer - We use tools to investigate ECM-metabolic-morphogenesis interplay to explore how tissues initiate, maintain and lose organization
Reposted by Abdel Rahman Abdel Fattah
Coffee break in full swing at #cellmech2025 —fueling up for the next session!
October 2, 2025 at 1:45 PM
What an incredible #cellmech2025 packed with science, ideas, and inspiration! 🚀 We loved sharing our work on ECM dynamics, mechanics & energy consumption in early development (Dunja Al-Nuaimi & Sowmya Sunkara). Grateful for this vibrant community ➡️ see you at CellMech 2027!
October 5, 2025 at 11:15 AM
What an incredible #cellmech2025 packed with science, ideas, and inspiration! 🚀 We loved sharing our work on ECM dynamics, mechanics & energy consumption in early development (Dunja Al-Nuaimi & Sowmya Sunkara). Grateful for this vibrant community ➡️ see you at CellMech 2027!
Reposted by Abdel Rahman Abdel Fattah
#BloodBrainBarrier
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
September 20, 2025 at 11:02 AM
#BloodBrainBarrier
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
"microglia are not necessary for the maintenance of BBB structure, function, or gene expression in the healthy brain"
Evidence from >95% microglia depletion by PLX5622, a CSF1R inhibitor (1 mo) & BBB ultrastructure
@cprofaci.bsky.social #Neuron 2024
www.cell.com/neuron/fullt...
🚨Preprint alert!🚨 Very happy that our lab could contribute to this new aging story by the @lderooij.bsky.social group, building a Human Aging Atlas with over 375,000 profiled endothelial cells, so many insights including a mechanical twist to our aging endothelium.
🚨Preprint alert!🚨What happens to our blood vessels as we age? To begin answering this at the transcriptome level, we built the Human Aging Endothelial Cell Atlas (HAECA), profiling >375,000 endothelial cells from 12 tissues across adulthood. www.biorxiv.org/content/10.1... (1/9)
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
August 21, 2025 at 9:04 AM
🚨Preprint alert!🚨 Very happy that our lab could contribute to this new aging story by the @lderooij.bsky.social group, building a Human Aging Atlas with over 375,000 profiled endothelial cells, so many insights including a mechanical twist to our aging endothelium.
Reposted by Abdel Rahman Abdel Fattah
On 7–8 July, CeMM Recess 2025 brought our postdoc community together!👩🔬👨🏾🔬
From scientific talks to bold science pitches, feedback, & evening quiz, a retreat full of ideas & inspiration!
Thanks to organisers Barbara Maier, @ar-abdelfattah.bsky.social, @dseruggia.bsky.social, & to all who joined! 👏
From scientific talks to bold science pitches, feedback, & evening quiz, a retreat full of ideas & inspiration!
Thanks to organisers Barbara Maier, @ar-abdelfattah.bsky.social, @dseruggia.bsky.social, & to all who joined! 👏
July 9, 2025 at 1:50 PM
On 7–8 July, CeMM Recess 2025 brought our postdoc community together!👩🔬👨🏾🔬
From scientific talks to bold science pitches, feedback, & evening quiz, a retreat full of ideas & inspiration!
Thanks to organisers Barbara Maier, @ar-abdelfattah.bsky.social, @dseruggia.bsky.social, & to all who joined! 👏
From scientific talks to bold science pitches, feedback, & evening quiz, a retreat full of ideas & inspiration!
Thanks to organisers Barbara Maier, @ar-abdelfattah.bsky.social, @dseruggia.bsky.social, & to all who joined! 👏
Reposted by Abdel Rahman Abdel Fattah
🔬 As we near the end of #EquationsForLife, today we spotlight @ar-abdelfattah.bsky.social's Group!
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
June 24, 2025 at 6:30 AM
🔬 As we near the end of #EquationsForLife, today we spotlight @ar-abdelfattah.bsky.social's Group!
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it.
🔎 bit.ly/4ef2Pbe
Reposted by Abdel Rahman Abdel Fattah
What’s the link between Origami and morphogenesis?
This is the world of Actuation, I’m @ar-abdelfattah.bsky.social, and I’ll share with you insights, experiments and an outlook on how epithelia use mechanical forces to gain geometrical and functional complexity.
This is the world of Actuation, I’m @ar-abdelfattah.bsky.social, and I’ll share with you insights, experiments and an outlook on how epithelia use mechanical forces to gain geometrical and functional complexity.
March 23, 2025 at 2:14 AM
What’s the link between Origami and morphogenesis?
This is the world of Actuation, I’m @ar-abdelfattah.bsky.social, and I’ll share with you insights, experiments and an outlook on how epithelia use mechanical forces to gain geometrical and functional complexity.
This is the world of Actuation, I’m @ar-abdelfattah.bsky.social, and I’ll share with you insights, experiments and an outlook on how epithelia use mechanical forces to gain geometrical and functional complexity.
very nice and comprehensive. methods to assess tissue stress. thanks for compiling this.
Tissues are dynamic and investigating cellular mechanical states can be crucial for understanding biological processes. But how to do it?
We are @andreasschoenit.bsky.social and @luanger.bsky.social from @bladoux.bsky.social / @rmmege.bsky.social lab highlighting ways to assess tissue stresses.
We are @andreasschoenit.bsky.social and @luanger.bsky.social from @bladoux.bsky.social / @rmmege.bsky.social lab highlighting ways to assess tissue stresses.
February 16, 2025 at 10:48 AM
very nice and comprehensive. methods to assess tissue stress. thanks for compiling this.
a very important tool for #ECMatrix enthusiasts!! I'm sure this will come in handy for many researchers.
Our manuscript describing #MatriCom, a web application we developed in collaboration with @valerioizzi.bsky.social to infer #ECM communication systems from #scRNASeq datasets is now available on @biorxivpreprint.bsky.social!
MatriCom: a scRNA-Seq data mining tool to infer ECM-ECM and cell-ECM communication systems https://www.biorxiv.org/content/10.1101/2024.12.10.627834v1
January 5, 2025 at 7:59 PM
a very important tool for #ECMatrix enthusiasts!! I'm sure this will come in handy for many researchers.
A very informative thread on this emerging field, the metabolic dimension of #mechanobiology!! nicely done.
How is metabolism interconnected with cellular dynamics? We are @emaniou.bsky.social and @hpscenthusiast.bsky.social and through an energy inexpensive process, we will highlight advances in mechano-metabolism and related fields. @epimechfc.bsky.social
December 15, 2024 at 8:31 AM
A very informative thread on this emerging field, the metabolic dimension of #mechanobiology!! nicely done.
Our #TBI project got funded! Driven by what happens when forces are too much to handle, we will engineer tools to traumatize organoids and focus on #ECMatrix dynamics, #mechanobiology, and molecular-to-multicellular tissue organization. Happy to collaborate! Happening @ CeMM
December 7, 2024 at 12:59 PM
Our #TBI project got funded! Driven by what happens when forces are too much to handle, we will engineer tools to traumatize organoids and focus on #ECMatrix dynamics, #mechanobiology, and molecular-to-multicellular tissue organization. Happy to collaborate! Happening @ CeMM
Reposted by Abdel Rahman Abdel Fattah
Hi #cancer, #ECMatrix, #biomaterials and #mechanobiology folks:
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option - Nature Cell Biology
Uroz et al. report that the distinct mechanical properties of brain vasculature versus parenchyma drive cancer cell migration through a talin-dependent mechanism, enabling vessel co-option and metasta...
www.nature.com
November 18, 2024 at 10:14 AM
Hi #cancer, #ECMatrix, #biomaterials and #mechanobiology folks:
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Below a Nat Cell Biol paper from the Chen and Weaver groups, of interest to many of us 🧪👇:
www.nature.com/articles/s41...
Reposted by Abdel Rahman Abdel Fattah
👋Hello #mechanobiology community!
Next year we are organizing the CellMech conference in Leuven!
We will soon be announcing (super amazing) invited speakers, registration deadlines, etc
I'll try to keep the🦋community updated, but best is to subscribe to the mailing list 📧👇
cellmech2025.org
Next year we are organizing the CellMech conference in Leuven!
We will soon be announcing (super amazing) invited speakers, registration deadlines, etc
I'll try to keep the🦋community updated, but best is to subscribe to the mailing list 📧👇
cellmech2025.org
November 20, 2024 at 9:12 AM
👋Hello #mechanobiology community!
Next year we are organizing the CellMech conference in Leuven!
We will soon be announcing (super amazing) invited speakers, registration deadlines, etc
I'll try to keep the🦋community updated, but best is to subscribe to the mailing list 📧👇
cellmech2025.org
Next year we are organizing the CellMech conference in Leuven!
We will soon be announcing (super amazing) invited speakers, registration deadlines, etc
I'll try to keep the🦋community updated, but best is to subscribe to the mailing list 📧👇
cellmech2025.org
Let's make this community even stronger! join, spread the word.
The #ECMatrix starter pack keeps growing! Be sure to follow all these fantastic researchers! 👇👇👇
go.bsky.app/47xREVJ
go.bsky.app/47xREVJ
November 29, 2024 at 3:06 AM
Let's make this community even stronger! join, spread the word.
Interested in metal transporters, #SLC, metal toxicity? check out the amazing work of Andrè Ferdigg from @supertifurgalab.bsky.social 👇
PhD student @AndreFerdigg and colleagues report in @LSAjournal on #SLC transporters in metal toxicity. MRP1/ABCC1 protects against arsenic and mercury; SLC39A14 and SLC30A1 sensitize for cadmium; interestingly SLC30A1 modulates cadmium toxicity through zinc levels doi.org/10.26508/lsa...
November 26, 2024 at 12:37 PM
Interested in metal transporters, #SLC, metal toxicity? check out the amazing work of Andrè Ferdigg from @supertifurgalab.bsky.social 👇
Reposted by Abdel Rahman Abdel Fattah
Pre-announcing the EMBO/EMBL symposium "Mechanobiology Across the Tree of Life", Heidelberg, 9-12 June 2026. It is still very very far away, but save the date 🗓️. With Alba Diz-Munoz, @nicolettapetridou.bsky.social , Kirsty Wan @micromotility.bsky.social, Enrique Rojas.
www.embl.org/about/info/c...
www.embl.org/about/info/c...
Mechanobiology across the tree of life
www.embl.org
November 20, 2024 at 4:49 PM
Pre-announcing the EMBO/EMBL symposium "Mechanobiology Across the Tree of Life", Heidelberg, 9-12 June 2026. It is still very very far away, but save the date 🗓️. With Alba Diz-Munoz, @nicolettapetridou.bsky.social , Kirsty Wan @micromotility.bsky.social, Enrique Rojas.
www.embl.org/about/info/c...
www.embl.org/about/info/c...
If you're interested in magnetic actuation and #mechanobiology, this is a very nice review! 🧲⚙️🧫
Excited to share a new review on Magnets for Mechanobiology - teamed up w/ fellow 🧲 enthusiasts from Boston/Madrid/Zurich/Singapore to share how we manipulate cellular microenvironments w/ magnetic fields! Thanks to @danielgmadrid11.bsky.social for bringing us together!
doi.org/10.1002/aisy...
doi.org/10.1002/aisy...
Magnetic Actuation for Mechanomedicine
In this perspective, the emergence of magneto-mechanical actuation systems in biomedical research and mechanomedicine is explored. These materials, ranging from single particles to 3D scaffolds, enab...
doi.org
November 26, 2024 at 3:40 AM
If you're interested in magnetic actuation and #mechanobiology, this is a very nice review! 🧲⚙️🧫
@bioeng-talk.bsky.social is posting here as well! Speaking of moving to new places (🦋), in this episode, a bunch of us discuss why we moved to Europe to continue our academic careers. Tune in to hear about our experiences and what motivated us to make the leap.
For our first post here 🦋, we discuss why some of us changed environments to pursue science, focusing on career moves that brought us to Europe. Are you planning to move for your next position? Hear us about our experiences, motivations, and the hurdles we faced.
t.co/5gRHhw2eef
t.co/5gRHhw2eef
https://spotifycreators-web.app.link/e/6hFYUzm3MOb
t.co
November 24, 2024 at 5:10 PM
@bioeng-talk.bsky.social is posting here as well! Speaking of moving to new places (🦋), in this episode, a bunch of us discuss why we moved to Europe to continue our academic careers. Tune in to hear about our experiences and what motivated us to make the leap.
Reposted by Abdel Rahman Abdel Fattah
Excited to join the 🦋 community, and even more excited to share that the lab has its very own logo & website! 🖥️🔎 Visit us at derooijlab.org to explore our work, stay updated on ongoing projects, papers, and more!
November 23, 2024 at 7:00 PM
Excited to join the 🦋 community, and even more excited to share that the lab has its very own logo & website! 🖥️🔎 Visit us at derooijlab.org to explore our work, stay updated on ongoing projects, papers, and more!
Let the first post be about our lab website! Happy to announce it's up and running. Our vision of controlling tissue organization and probing its mechanics is rather magnetic 🧲⚙️🧫🧬! #mechanobiology
👉 www.abdelfattahlab.org
👉 www.abdelfattahlab.org
Abdel Fattah Lab
www.abdelfattahlab.org
November 23, 2024 at 2:25 PM
Let the first post be about our lab website! Happy to announce it's up and running. Our vision of controlling tissue organization and probing its mechanics is rather magnetic 🧲⚙️🧫🧬! #mechanobiology
👉 www.abdelfattahlab.org
👉 www.abdelfattahlab.org