APPRIS database
@appris.bsky.social
APPRIS database and webserver updates, announcements and new releases.
APPRIS: https://appris.bioinfo.cnio.es/#/
APPRIS: https://appris.bioinfo.cnio.es/#/
We have recalculated APPRIS principal isoforms for GENCODE v48 / Ensembl 114 human.
GENCODE added loss of function genes to this version and we discovered that this caused the TRIFID scores to change, affecting some of the PRINCIPAL:2 -> PRINCIPAL:5 isoforms.
Our fault, we asked for the change!
GENCODE added loss of function genes to this version and we discovered that this caused the TRIFID scores to change, affecting some of the PRINCIPAL:2 -> PRINCIPAL:5 isoforms.
Our fault, we asked for the change!
October 15, 2025 at 2:02 PM
We have recalculated APPRIS principal isoforms for GENCODE v48 / Ensembl 114 human.
GENCODE added loss of function genes to this version and we discovered that this caused the TRIFID scores to change, affecting some of the PRINCIPAL:2 -> PRINCIPAL:5 isoforms.
Our fault, we asked for the change!
GENCODE added loss of function genes to this version and we discovered that this caused the TRIFID scores to change, affecting some of the PRINCIPAL:2 -> PRINCIPAL:5 isoforms.
Our fault, we asked for the change!
Reposted by APPRIS database
FlyBase needs your help!
Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org
Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org
June 9, 2025 at 2:42 PM
FlyBase needs your help!
Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org
Because of recent changes to government funding, the NIH grant that supported FlyBase has been "terminated." flybase.org
We have updated APPRIS to @gencodegenes.bsky.social v48/ @ensembl.bsky.social v114. New principal isoforms for human, mouse, rat, cow and fruit fly ( @flybase.bsky.social ).
Principal isoforms for a total of 73 human genes have been updated manually.
Principal isoforms for a total of 73 human genes have been updated manually.
June 12, 2025 at 1:21 PM
We have updated APPRIS to @gencodegenes.bsky.social v48/ @ensembl.bsky.social v114. New principal isoforms for human, mouse, rat, cow and fruit fly ( @flybase.bsky.social ).
Principal isoforms for a total of 73 human genes have been updated manually.
Principal isoforms for a total of 73 human genes have been updated manually.
Users of APPRIS may have noticed that there is a new category of principal isoforms, Principal:M.
These principal isoforms are exclusive to the human gene set and are principal isoforms that have been manually corrected. In GENCODE v47 there were 45 genes with Principal:M isoforms.
Here is DCD:
These principal isoforms are exclusive to the human gene set and are principal isoforms that have been manually corrected. In GENCODE v47 there were 45 genes with Principal:M isoforms.
Here is DCD:
February 24, 2025 at 12:21 PM
Users of APPRIS may have noticed that there is a new category of principal isoforms, Principal:M.
These principal isoforms are exclusive to the human gene set and are principal isoforms that have been manually corrected. In GENCODE v47 there were 45 genes with Principal:M isoforms.
Here is DCD:
These principal isoforms are exclusive to the human gene set and are principal isoforms that have been manually corrected. In GENCODE v47 there were 45 genes with Principal:M isoforms.
Here is DCD:
Nice try, Luka. But even in a sham election with the real opposition candidates in jail, that is still some way short. of the 99.86% of supported ClinVar pathogenic mutations that map to APPRIS principal isoforms ...
January 27, 2025 at 11:03 AM
Nice try, Luka. But even in a sham election with the real opposition candidates in jail, that is still some way short. of the 99.86% of supported ClinVar pathogenic mutations that map to APPRIS principal isoforms ...
APPRIS has updated to GENCODE v47 and mouse M36. Danio rerio has also been updated to Ensembl 113.
in this release 80.7% of human coding genes have a PRINCIPAL:1 isoform.
Also, we have begun the manual curation of principal isoforms. More soon.
@gencodegenes.bsky.social @ensembl.bsky.social
in this release 80.7% of human coding genes have a PRINCIPAL:1 isoform.
Also, we have begun the manual curation of principal isoforms. More soon.
@gencodegenes.bsky.social @ensembl.bsky.social
January 22, 2025 at 10:35 AM
APPRIS has updated to GENCODE v47 and mouse M36. Danio rerio has also been updated to Ensembl 113.
in this release 80.7% of human coding genes have a PRINCIPAL:1 isoform.
Also, we have begun the manual curation of principal isoforms. More soon.
@gencodegenes.bsky.social @ensembl.bsky.social
in this release 80.7% of human coding genes have a PRINCIPAL:1 isoform.
Also, we have begun the manual curation of principal isoforms. More soon.
@gencodegenes.bsky.social @ensembl.bsky.social
APPRIS has new annotations for GENCODE human v46 and mouse M35. The human reference set now has 16,483 genes with Principal:P1 isoforms and mouse has 18,782 genes.
Agreement with MANE Select transcripts in human (no MANE Select in mouse) has risen slightly to 17,661 genes.
appris.bioinfo.cnio.es#/
Agreement with MANE Select transcripts in human (no MANE Select in mouse) has risen slightly to 17,661 genes.
appris.bioinfo.cnio.es#/
{APPRIS} - Annotating principal splice isoforms
Explore and download data on alternative splicing annotations and principal isoforms with the APPRIS Database, WebServer and WebServices.
appris.bioinfo.cnio.es
July 3, 2024 at 3:29 PM
APPRIS has new annotations for GENCODE human v46 and mouse M35. The human reference set now has 16,483 genes with Principal:P1 isoforms and mouse has 18,782 genes.
Agreement with MANE Select transcripts in human (no MANE Select in mouse) has risen slightly to 17,661 genes.
appris.bioinfo.cnio.es#/
Agreement with MANE Select transcripts in human (no MANE Select in mouse) has risen slightly to 17,661 genes.
appris.bioinfo.cnio.es#/
APPRIS in use ...
We have just published a paper in which we take an in depth look at translation of 5' UTR regions.
The key takeaways are that it is common and that most translation from 5' UTR is in-frame, so the effect at the protein level is to extend the N-terminal.
academic.oup.com/nar/advance-...
The key takeaways are that it is common and that most translation from 5' UTR is in-frame, so the effect at the protein level is to extend the N-terminal.
academic.oup.com/nar/advance-...
Evidence for widespread translation of 5′ untranslated regions
Abstract. Ribosome profiling experiments support the translation of a range of novel human open reading frames. By contrast, most peptides from large-scale
academic.oup.com
July 3, 2024 at 12:51 PM
APPRIS in use ...
APPRIS has annotated principal and alternative isoforms and TRIFID functional isoform scores for Ensembl Bos taurus version e111: appris.bioinfo.cnio.es#/
March 26, 2024 at 12:27 PM
APPRIS has annotated principal and alternative isoforms and TRIFID functional isoform scores for Ensembl Bos taurus version e111: appris.bioinfo.cnio.es#/