Antebi Lab
@antebilab.bsky.social
Department of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing
https://www.age.mpg.de/antebi/research
https://www.age.mpg.de/antebi/research
🚨New @biorxivpreprint: We model the splicing factor disease Verheij syndrome using C. elegans. Disruption of methionine and phospholipid metabolism drives growth defects; vitamin #B12 restores metabolic balance and rescues development! #metabolism #Celegans #RNAsplicing
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Vitamin B12 alleviates Verheij syndrome-like defects via phospholipid remodeling in a C. elegans PUF60 spliceosomopathy model
Verheij syndrome (VRJS) is a rare genetic disorder caused by mutations in the poly(U)-binding splicing factor 60 (PUF60), a core component of the spliceosomal complex. VRJS triggers multiple congenita...
doi.org
October 8, 2025 at 2:14 PM
🚨New @biorxivpreprint: We model the splicing factor disease Verheij syndrome using C. elegans. Disruption of methionine and phospholipid metabolism drives growth defects; vitamin #B12 restores metabolic balance and rescues development! #metabolism #Celegans #RNAsplicing
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Eugene, Victoria & Tabrez are just back from Copenhagen🇩🇰 #ARDD2025! Kazuto (@kkawamura13.bsky.social) took the stage to share his insights on fasting-refeeding and age-restoration. ⌛️🍽️ Turns out, the fountain of youth might just be a histone away!🪱🔬 #Rejuvenation #AgingResearch
September 4, 2025 at 11:14 AM
Eugene, Victoria & Tabrez are just back from Copenhagen🇩🇰 #ARDD2025! Kazuto (@kkawamura13.bsky.social) took the stage to share his insights on fasting-refeeding and age-restoration. ⌛️🍽️ Turns out, the fountain of youth might just be a histone away!🪱🔬 #Rejuvenation #AgingResearch
Our lab's BBQ last Friday was a blast! Meticulous research revealed the ultimate anti-aging formula: juicy burgers and great company! 🍔👩🔬 #AgingResearch
August 18, 2025 at 1:01 PM
Our lab's BBQ last Friday was a blast! Meticulous research revealed the ultimate anti-aging formula: juicy burgers and great company! 🍔👩🔬 #AgingResearch
🏆⚽️ A huge shoutout to the Antebi lab's team 'C(riminally) elegant' for winning the human Foosball match at the CECAD Summer Party @cecad.bsky.social! Your elegance on the field is unmatched!💪 #LabLegends #Foosball
July 7, 2025 at 3:52 PM
🏆⚽️ A huge shoutout to the Antebi lab's team 'C(riminally) elegant' for winning the human Foosball match at the CECAD Summer Party @cecad.bsky.social! Your elegance on the field is unmatched!💪 #LabLegends #Foosball
1/7 🚨Out now @nataging.nature.com 🚨 We identified a genetic network of TFEB, TGFβ and NOTCH signaling regulating stem cell resilience, rejuvenation & senescence in C. elegans in response to nutrient cues, with conservation across taxa. www.nature.com/articles/s43...
A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state - Nature Aging
Nonninger et al. identify the TFEB–TGFβ signaling axis as a regulator of stem cell resilience that protects against a senescence-like state during the adult diapause in Caenorhabditis elegans, a mecha...
www.nature.com
June 30, 2025 at 9:32 AM
1/7 🚨Out now @nataging.nature.com 🚨 We identified a genetic network of TFEB, TGFβ and NOTCH signaling regulating stem cell resilience, rejuvenation & senescence in C. elegans in response to nutrient cues, with conservation across taxa. www.nature.com/articles/s43...
Reposted by Antebi Lab
🎊Today, we're excited to celebrate the graduation of our amazing 13 students from the CGA Class of 2021! We’re so proud of all their accomplishments.
🎓Come join us now as they present their PhD projects at the 13th CGA Graduate Symposium.
And, of course, we can’t wait for the dinner party tonight!🍾
🎓Come join us now as they present their PhD projects at the 13th CGA Graduate Symposium.
And, of course, we can’t wait for the dinner party tonight!🍾
June 12, 2025 at 12:26 PM
🎊Today, we're excited to celebrate the graduation of our amazing 13 students from the CGA Class of 2021! We’re so proud of all their accomplishments.
🎓Come join us now as they present their PhD projects at the 13th CGA Graduate Symposium.
And, of course, we can’t wait for the dinner party tonight!🍾
🎓Come join us now as they present their PhD projects at the 13th CGA Graduate Symposium.
And, of course, we can’t wait for the dinner party tonight!🍾
🥳Congratulations @annadiederich01.bsky.social for successfully defending your master's thesis. Great collaboration with the Demetriades Lab. We are thrilled to also accompany you on your PhD journey. To many more interesting findings! 🥂
June 11, 2025 at 2:17 PM
🥳Congratulations @annadiederich01.bsky.social for successfully defending your master's thesis. Great collaboration with the Demetriades Lab. We are thrilled to also accompany you on your PhD journey. To many more interesting findings! 🥂
Last week we said goodbye to our PhD student-turned-postdoc Tim! We are sad to see you go, but confident that you will do great things wherever your journey takes you next! 👨🔬#Farewell
June 5, 2025 at 9:40 AM
Last week we said goodbye to our PhD student-turned-postdoc Tim! We are sad to see you go, but confident that you will do great things wherever your journey takes you next! 👨🔬#Farewell
Reposted by Antebi Lab
👩🎓We're thrilled to share some wonderful news! Klara Schilling from the CGA Class of 2020 successfully defended her PhD thesis today!
Klara, we hope you're enjoying some well-deserved celebrations right now! 🥂🎊 @mpiage.bsky.social @antebilab.bsky.social
Klara, we hope you're enjoying some well-deserved celebrations right now! 🥂🎊 @mpiage.bsky.social @antebilab.bsky.social
May 6, 2025 at 8:53 PM
👩🎓We're thrilled to share some wonderful news! Klara Schilling from the CGA Class of 2020 successfully defended her PhD thesis today!
Klara, we hope you're enjoying some well-deserved celebrations right now! 🥂🎊 @mpiage.bsky.social @antebilab.bsky.social
Klara, we hope you're enjoying some well-deserved celebrations right now! 🥂🎊 @mpiage.bsky.social @antebilab.bsky.social
Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Resilience and restoration from fasting-refeeding mediated by a nutrient-regulated linker histone
Intermittent fasting and fasting-refeeding regimens can slow biological aging across taxa[1][1]. Shifts between fed and fasted states activate ancient nutrient-sensing pathways which alter cellular an...
www.biorxiv.org
April 28, 2025 at 8:31 AM
Preprint alert @biorxivpreprint! We are excited to share our latest study led by @kkawamura13.bsky.social @annadiederich01.bsky.social in collaboration with & C. Demetriades Lab & @muellerrom.bsky.social Lab
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...