Anna Nordin
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annanordin.bsky.social
Anna Nordin
@annanordin.bsky.social
140 followers 440 following 0 posts
PhD student in the Cantù lab studying Wnt signaling and chromatin. Avid CUT&RUN-er 🥼🧬🇺🇸🇸🇪
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Reposted by Anna Nordin
claudiocantu81.bsky.social
SOX2 and NR2F1 cooperate
to make #neurons in the #Thalamus
for visual input from the #retina

#DevBio

journals.biologists.com/bio/article/...
‪
@biologyopen.bsky.social

In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social

Driven by Linda Serra and @annanordin.bsky.social
SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus
Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.
journals.biologists.com
August 11, 2025 at 12:55 PM
Reposted by Anna Nordin
claudiocantu81.bsky.social
A 6-year long study from the Lab is finally out @genomeresearch.bsky.social

Mastered by @annanordin.bsky.social in collaboration with Chaitali Chakraborty from @remeseiro-lab.bsky.social

Why is our work Important? Discover it in the quick Bluetorial 👇

genome.cshlp.org/content/earl...
Wnt signaling activation induces CTCF binding and loop formation at cis-regulatory elements of target genes
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
July 15, 2025 at 7:58 AM
Reposted by Anna Nordin
claudiocantu81.bsky.social
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio

We now have a shocking finding, just published in @pnas.org

TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC)

www.pnas.org/doi/epub/10....
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
www.pnas.org
May 12, 2025 at 7:33 AM
Reposted by Anna Nordin
dev-journal.bsky.social
Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions

Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....
Figure 1 TFBomics of the E11.5 mouse embryo. (A) Schematic overview of the experimental design, detailing the tissues dissected from E11.5 JAX/Swiss mice and the targets profiled in each tissue using C&R LoV-U. (B) Left: Clustering of data according to Spearman's correlation. Black boxes highlight higher correlation or clustering according to the profiled factor, whereas red boxes highlight this between factors within the same tissue. IgG negative controls are highlighted in a gray box. Right: Overall data patterns shown by PCA. PC1 (58.7% of variance) separated some samples by the target factor (ellipses shaded by factor color code), while PC2 (9.7% of variance) typically separates the liver (marked with stars) from other tissues.
March 29, 2025 at 9:51 AM
Reposted by Anna Nordin
claudiocantu81.bsky.social
Our first release in the attempt to build the Transcription Factor Binding (TFB)-OMICS during #DevBio is now out in Development @dev-journal.bsky.social
doi.org/10.1242/dev....
👉We hope many will use our data, and some will want to help mapping their beloved gene regulators in their favorite tissue
claudiocantu81.bsky.social Claudio Cantù @claudiocantu81.bsky.social · Dec 3
We are using CUT&RUN-LoV-U to map effectors of Signaling Pathways across tissue and stages of Mouse #DevBio🐭🧬

Do you want to join forces and collaborate to build the future of the TranscriptionFactorBinding(TFB)-OMICS?
www.biorxiv.org/content/10.1...
March 18, 2025 at 7:18 AM