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Andy

@andyjobbins.bsky.social

Two great papers just dropped from the Ramich lab, exploring the effects of isocaloric time-restricted eating in women with overweight or obesity (ChronoFast trial).

advanced.onlinelibrary.wiley.com/doi/full/10....
www.science.org/doi/10.1126/...

Impact of Intended Isocaloric Early versus Late Time‐Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial

Women with overweight or obesity follow intended isocaloric early and late time-restricted eating (TRE) in a crossover trial. Shotgun plasma lipidomics reveals no significant differences between inte...

advanced.onlinelibrary.wiley.com

November 5, 2025 at 3:13 PM

Andy

@andyjobbins.bsky.social

A paper published in Advanced Science describes a study which tests an #AdaptiveIntervention for people post- #Stroke recovery. Findings suggest that switching interventions for non-responders may improve outcomes like fatigue and daily step count.
advanced.onlinelibrary.wiley.com/doi/full/10....

The Adaptive Physical Activity Study in Stroke (TAPAS): A Feasibility Sequential Multiple Assignment Randomized Trial

This study examines the feasibility of a mobile health physical activity intervention for individuals post-stroke using a sequential multiple assignment randomized trial (SMART) design. High recruitm....

advanced.onlinelibrary.wiley.com

October 28, 2025 at 12:42 PM

Andy

@andyjobbins.bsky.social

Do we already have the drugs we need for the diseases at hand and is #AI the key to finding these hidden gems?
A paper published in #AdvancedScience demonstrates that a "AI co-scientist" can guide the repurposing of drugs for #liverfibrosis.

advanced.onlinelibrary.wiley.com/doi/10.1002/...

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis

A multi-agent AI (AI co-scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti-fibrotic efficacy and toxicity of these drugs is ...

advanced.onlinelibrary.wiley.com

September 16, 2025 at 12:27 PM

Andy

@andyjobbins.bsky.social

A pair of nice aging clock papers published in Advanced Science to highlight this week from the Pircs and Kerepesi labs, and Lasky-Su and Teschendorff labs.

#Aging #Longevity #Neuroscience

advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/full/10....

September 3, 2025 at 10:05 AM

Andy

@andyjobbins.bsky.social

In this study from Advanced Science, researchers developed nanoparticles which induce vasodilation, that specifically target high-shear collateral vessels, boosting blood flow to stroke affected brain areas and improve recovery.
#Stroke #Neuroscience
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome

Shear-activated nanoparticles carrying nitroglycerin selectively target high-shear stress collateral vessels during ischaemic stroke, enhancing blood flow to at-risk brain without systemic side effec...

advanced.onlinelibrary.wiley.com

August 28, 2025 at 1:15 PM

Andy

@andyjobbins.bsky.social

Advanced Science study demonstrates that enhanced brain-to-heart connectivity is a key physiological precursor to reduced anxiety following a virtual reality-based therapeutic intervention.

#Neurocardiology #BrainHeartConnection #VirtualReality

advanced.onlinelibrary.wiley.com/doi/10.1002/...

August 18, 2025 at 11:48 AM

Andy

@andyjobbins.bsky.social

An eye opening paper demonstrates that a dose of oxytocin reduces fear in social contexts. Oxytocin is also most commonly associated with love so could these findings underlie why we feel safer with loved ones around?

#Neuroscience #Oxytocin

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

This double-blind, placebo-controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non-social) contexts. Concomitant fMRI reveals tha...

advanced.onlinelibrary.wiley.com

August 11, 2025 at 2:16 PM

Andy

@andyjobbins.bsky.social

An interdisciplinary paper from Advanced Science presents a ML platform that uses a brain-specific aging clock to identify interventions capable of rejuvenating brain cells.
#Neuroscience #Aging #BrainRejuvenation #Neurodegeneration
advanced.onlinelibrary.wiley.com/doi/10.1002/...

advanced.onlinelibrary.wiley.com

August 4, 2025 at 1:10 PM

Andy

@andyjobbins.bsky.social

A new systematic review from Advanced Science highlights the rapid evolution of implantable brain–computer interfaces (iBCIs) advocates for meaningful, user-centered metrics.

#BrainComputerInterface #iBCI #Neuroscience #ClinicalTrials

advanced.onlinelibrary.wiley.com/doi/10.1002/...

advanced.onlinelibrary.wiley.com

July 30, 2025 at 2:51 PM

Andy

@andyjobbins.bsky.social

A new article shows how DEC2 calms overactive brain cells by turning off a gene linked to seizures. They also show that CBD works by boosting DEC2, which could lead to new treatments for epilepsy.

#Epilepsy #CBD #Neuroscience #Seizure #Cannabidiol

advanced.onlinelibrary.wiley.com/doi/10.1002/...

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E-box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulati...

advanced.onlinelibrary.wiley.com

July 21, 2025 at 1:31 PM

Andy

@andyjobbins.bsky.social

New study in Advanced Science discusses Multi-Region Brain Organoids (MRBOs) that integrate cerebral, mid/hindbrain, and endothelial systems to model human neurodevelopment more accurately.

#Neurodevelopment #BrainOrganoids #HumanBrainModel

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Multi-Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential end...

advanced.onlinelibrary.wiley.com

July 14, 2025 at 2:36 PM

Andy

@andyjobbins.bsky.social

New study in Advanced Science investigates finds that blocking CGRP-expressing neurons in the parabrachial nucleus can significantly reduce sleep loss caused by acute pain.

#Pain #Sleep #Neuroscience #CGRP

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Calcitonin Gene‐Related Peptide (CGRP)‐Expressing Neurons in the External Lateral Parabrachial Area Regulate Pain‐Induced Sleep Disturbances

Lynch et al., identified novel targets on the wake-promoting pathways that can effectively treat pain-induced sleep disturbances. The authors demonstrated that Calcitonin gene-related peptide-express....

advanced.onlinelibrary.wiley.com

July 1, 2025 at 3:39 PM

Andy

@andyjobbins.bsky.social

New review in Advanced Science, "The State of High-Resolution Imaging of the Human Inner Ear: A Look Into the Black Box".

The article discusses the challenges and future of imaging the human inner ear.

#InnerEarImaging #HighResolutionImaging

advanced.onlinelibrary.wiley.com/doi/10.1002/...

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

High-resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic ...

advanced.onlinelibrary.wiley.com

June 9, 2025 at 2:56 PM

Andy

@andyjobbins.bsky.social

Study out in Advanced Science:

The TALENTs study found that nucleotides supplementation reduced DNA methylation age and improved insulin sensitivity in older adults, suggesting potential anti-aging benefits.

#Aging #Biologicalage #Supplements

advanced.onlinelibrary.wiley.com/doi/10.1002/...