Andre Schwarz
@andschwarz.bsky.social
Postdoc w/ Erin Schuman @MpiBrain studying protein complexes in neurons using cryoET. PhD @EMBL Heidelberg @Beck_Laboratory.
Reposted by Andre Schwarz
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
November 6, 2025 at 7:38 AM
Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
Reposted by Andre Schwarz
We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....
October 29, 2025 at 4:40 PM
We are looking for an enthusiastic postdoc to investigate cellular dormancy and ribosome hibernation across plants, fungi, and mammals using #cryoET. If you are interested, apply here: careers.exeter.ac.uk/vacancies/66....
Reposted by Andre Schwarz
#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...
Link: www.biorxiv.org/content/10.1...
October 5, 2025 at 6:37 PM
#TeamTomo ❄️🔬 meets #MassSpec Imaging 🧬🔬. Super cool, and great potential for EM grids with mixes of different cell types. For example -- environmental samples! @embltrec.bsky.social 🌍 🧪
Reposted by Andre Schwarz
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...
Link: www.biorxiv.org/content/10.1...
September 19, 2025 at 6:07 PM
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...
Link: www.biorxiv.org/content/10.1...
Reposted by Andre Schwarz
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 6:44 PM
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
Reposted by Andre Schwarz
Excited to share our latest collaborative work from Erin Schuman's lab @mpibrain.bsky.social : An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution, now published in @natcomms.nature.com. Here’s a thread summary 🧵
doi.org/10.1038/s414...
doi.org/10.1038/s414...
August 29, 2025 at 11:23 AM
Excited to share our latest collaborative work from Erin Schuman's lab @mpibrain.bsky.social : An integrated transcriptomic and proteomic map of the mouse hippocampus at synaptic resolution, now published in @natcomms.nature.com. Here’s a thread summary 🧵
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Reposted by Andre Schwarz
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
The small GTPase Ran defines nuclear pore complex asymmetry
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…
www.sciencedirect.com
August 18, 2025 at 4:26 PM
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Reposted by Andre Schwarz
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
August 18, 2025 at 11:29 AM
We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
Reposted by Andre Schwarz
Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...
August 15, 2025 at 4:09 PM
Extremely excited for the second version of this workshop at the MPI of Biophysics l, Frankfurt, that will happen 12-20. April 2026. Absolutely amazing lineup of speakers, I am very much looking forward to learning from everyone! Apply here: meetings.embo.org/event/26-in-...
Reposted by Andre Schwarz
Beautiful. I loved every moment of this project ❤️
🔬 Check out our new article on the mitochondrial TOM complex! Researchers from the Structural Biology Department have resolved a high-resolution structure of the main entry point for proteins into mitochondria. 🚪 🤩
Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019
Read more: www.biophys.mpg.de/2876415/tom-main-gate-into-mitochondria?c=2011019
Visualizing the Main Gate into Mitochondria
www.biophys.mpg.de
July 21, 2025 at 3:46 PM
Beautiful. I loved every moment of this project ❤️
Very proud of Lea and well deserved! Watch out for more to come..
Big congratulations to Dr. Lea Dietrich @lea-dietrich.bsky.social for receiving the Otto Hahn Medal from the @maxplanck.de for her research on mitochondrial architecture! 🏅 A brilliant young scientist and a great role model 💪
July 2, 2025 at 11:21 AM
Very proud of Lea and well deserved! Watch out for more to come..
Reposted by Andre Schwarz
New Preprint out !
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
April 28, 2025 at 3:08 PM
New Preprint out !
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...
Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more
Short thread below 🧵1/4
Reposted by Andre Schwarz
🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
April 25, 2025 at 7:28 AM
🦠🧠 MemBrain update! 🧠🦠
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics.
🔗 Preprint: doi.org/10.1101/2024...
🔗 Code: github.com/CellArchLab/...
🧵(1/6) #TeamTomo
Reposted by Andre Schwarz
Please enjoy our (@pamornelas.bsky.social and I) work on the cryoEM structures of TOM from Chaetomium thermophilum, revealing insights into the early stages of preprotein translocation. The paper is still under review, so fingers crossed 🤞. www.biorxiv.org/content/10.1... @mpibp.bsky.social
Structures of Chaetomium thermophilum TOM complexes with bound preproteins
Mitochondria import most of their proteins from the cytoplasm through the TOM complex. Preproteins containing targeting signals are recognized by the TOM receptor subunits, and translocated by Tom40 a...
www.biorxiv.org
April 21, 2025 at 4:04 PM
Please enjoy our (@pamornelas.bsky.social and I) work on the cryoEM structures of TOM from Chaetomium thermophilum, revealing insights into the early stages of preprotein translocation. The paper is still under review, so fingers crossed 🤞. www.biorxiv.org/content/10.1... @mpibp.bsky.social
Reposted by Andre Schwarz
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Reposted by Andre Schwarz
Excited to share our latest work on nuclear pore complex scaffold integrity and its perturbation. Now out in Nature Cell Biology: rdcu.be/eg4i9
Great work by Reiya Taniguchi who just opened his own research group back in Japan! 🥳
Great work by Reiya Taniguchi who just opened his own research group back in Japan! 🥳
Nuclear pores safeguard the integrity of the nuclear envelope
Nature Cell Biology - Taniguchi et al. structurally analyse nuclear pore complex architecture in situ during differentiation, which is associated with mechanical constraints on the nuclear...
rdcu.be
April 9, 2025 at 3:49 PM
Excited to share our latest work on nuclear pore complex scaffold integrity and its perturbation. Now out in Nature Cell Biology: rdcu.be/eg4i9
Great work by Reiya Taniguchi who just opened his own research group back in Japan! 🥳
Great work by Reiya Taniguchi who just opened his own research group back in Japan! 🥳
I remember Sven showing me these images almost three years ago, late at night, after many beers. We brainstormed what these things might be.. Turns out I was really far off and it's so much cooler! Congrats Sven, beautiful as always.
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
March 5, 2025 at 6:56 PM
I remember Sven showing me these images almost three years ago, late at night, after many beers. We brainstormed what these things might be.. Turns out I was really far off and it's so much cooler! Congrats Sven, beautiful as always.
Reposted by Andre Schwarz
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
March 5, 2025 at 4:02 PM
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
Reposted by Andre Schwarz
Congratulations to @mpibrain.bsky.social director Gilles Laurent for being awarded the 2025 Louis-Jeantet prize for Medicine! The @louisjeantetfdn.bsky.social recognizes Laurent's pioneering work on the operations of #neurons and dynamics of neuronal networks. More infos 👉 bit.ly/4hqk6ie
Gilles Laurent is awarded the Louis-Jeantet Prize for Medicine in 2025
The 2025 Louis-Jeantet Prizes are awarded to Gilles Laurent, director at the Max Planck Institute for Brain Research in Frankfurt and to Veit Hornung, professor at the Ludwig Maximilian University of ...
brain.mpg.de
January 21, 2025 at 2:15 PM
Congratulations to @mpibrain.bsky.social director Gilles Laurent for being awarded the 2025 Louis-Jeantet prize for Medicine! The @louisjeantetfdn.bsky.social recognizes Laurent's pioneering work on the operations of #neurons and dynamics of neuronal networks. More infos 👉 bit.ly/4hqk6ie
Reposted by Andre Schwarz
I'm thrilled to be opening my own lab this Fall at the @maxplanck.de MPI for Brain Research in Frankfurt. The lab is going to investigate the neuronal and genetic underpinnings of behavioral evolution. We are hiring on all levels. Don't hesitate to share widely and reach out if interested.
January 8, 2025 at 4:53 PM
I'm thrilled to be opening my own lab this Fall at the @maxplanck.de MPI for Brain Research in Frankfurt. The lab is going to investigate the neuronal and genetic underpinnings of behavioral evolution. We are hiring on all levels. Don't hesitate to share widely and reach out if interested.
Reposted by Andre Schwarz
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:43 PM
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
Reposted by Andre Schwarz
Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO
January 17, 2025 at 4:34 PM
Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO
Reposted by Andre Schwarz
At the intersection of art and science 🎨🧪 some masterpieces reveal fascinating lessons in #biophysics! Join Prof. Werner Kühlbrandt on a unique tour of the Städel Museum, where he explores mirror symmetry, cellular energy, and more. Read more: www.biophys.mpg.de/2840124/art-... 🔗
#ArtMeetsScience
#ArtMeetsScience
January 7, 2025 at 9:14 AM
At the intersection of art and science 🎨🧪 some masterpieces reveal fascinating lessons in #biophysics! Join Prof. Werner Kühlbrandt on a unique tour of the Städel Museum, where he explores mirror symmetry, cellular energy, and more. Read more: www.biophys.mpg.de/2840124/art-... 🔗
#ArtMeetsScience
#ArtMeetsScience
Reposted by Andre Schwarz
Did you know that nuclear pore complexes can show up outside the ☢️ ✉️? This study by Jenny Sachweh and her colleagues uncovers that the surrounding cellular milieu determines NPC composition via the nuclear transport system. #teamtomo #NPC #cryoET ❄️🔬
The small GTPase Ran defines Nuclear Pore Complex asymmetry https://www.biorxiv.org/content/10.1101/2024.10.10.617378v1
The small GTPase Ran defines Nuclear Pore Complex asymmetry https://www.biorxiv.org/content/10.1101/2024.10.10.617378v1
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic excha
www.biorxiv.org
October 13, 2024 at 2:48 PM