Andrew Martins
@andrewjmartins.bsky.social
Human & Systems Immunology
Yale Immunobiology & CSEI
Yale Immunobiology & CSEI
Reposted by Andrew Martins
Our new study on #systemsimmunology analysis of #Alzheimers patients is out now at @alzdemjournals.bsky.social!
This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
A systems immunology analysis of Alzheimer's disease reveals an age‐ and environmental exposure‐independent disturbance in B cell maturation
INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal mode...
alz-journals.onlinelibrary.wiley.com
November 26, 2025 at 12:02 PM
Our new study on #systemsimmunology analysis of #Alzheimers patients is out now at @alzdemjournals.bsky.social!
This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Andrew Martins
Countries like the US need to lead on revolutionizing science publishing making especially govt. funded science truly accessible to all without siphoning huge amounts of funds into for profit publishing houses. 4/
December 3, 2024 at 4:56 PM
Countries like the US need to lead on revolutionizing science publishing making especially govt. funded science truly accessible to all without siphoning huge amounts of funds into for profit publishing houses. 4/
Reposted by Andrew Martins
Excited to see our study on genetic regulation in heterogeneous differentiating cultures out in final form!
www.cell.com/cell-genomics/fulltext/S2666-979X(24)00330-6
www.cell.com/cell-genomics/fulltext/S2666-979X(24)00330-6
Cell type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures
Popp et al. generate dozens of cell types from 53 human iPSC lines in order to characterize
the dynamic genetic regulation of gene expression across early stages of cellular
differentiation. Accessing...
www.cell.com
December 4, 2024 at 2:31 AM
Excited to see our study on genetic regulation in heterogeneous differentiating cultures out in final form!
www.cell.com/cell-genomics/fulltext/S2666-979X(24)00330-6
www.cell.com/cell-genomics/fulltext/S2666-979X(24)00330-6
Reposted by Andrew Martins
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8