Andrew Grotzinger
@andrewgrotzinger.bsky.social
Assistant Professor at CU Boulder interested in multivariate genomic methods development and their application to understanding shared and unique signal across human disease and risk factors.
The title on 2 😱 you're in too deep Perline 🤣
May 22, 2025 at 1:33 PM
The title on 2 😱 you're in too deep Perline 🤣
I'm not 100% sure, but think if you have the data already downloaded you can run local analyses. Otherwise my sense if you have to analyze on RAP.
May 16, 2025 at 7:52 PM
I'm not 100% sure, but think if you have the data already downloaded you can run local analyses. Otherwise my sense if you have to analyze on RAP.
GNA estimates conditional genetic associations across traits, SNPs, or genes. In an empirical application, we show that a GWAS of Type 2 Diabetes implicates broad pathways (e.g. chemical reactions in the body) whereas SNP-level GNA results pinpoint core disease processes (e.g. insulin secretion) 2/2
Genomic network analysis characterizes genetic architecture and identifies trait-specific biology
Pervasive genetic overlap across human complex traits necessitates developing multivariate methods that can parse pleiotropic and trait-specific genetic signals. Here, we introduce Genomic Network Ana...
www.medrxiv.org
December 6, 2024 at 4:02 PM
GNA estimates conditional genetic associations across traits, SNPs, or genes. In an empirical application, we show that a GWAS of Type 2 Diabetes implicates broad pathways (e.g. chemical reactions in the body) whereas SNP-level GNA results pinpoint core disease processes (e.g. insulin secretion) 2/2
My take would be that start values are conceptually the closest to what you are describing. Most softwares allow for specifying this in some fashion. This tells the SEM software to start by trying out the suggested values and then expands the search space from there.
September 26, 2024 at 3:22 PM
My take would be that start values are conceptually the closest to what you are describing. Most softwares allow for specifying this in some fashion. This tells the SEM software to start by trying out the suggested values and then expands the search space from there.
Here's a picture of my current lab (graduate students Luke Schaffer, Jeremy Lawrence, Sophie Breunig and my postdoc Dr. Isy Foote). We are a collaborative, productive, and nice group and I hope you'll consider joining us!
September 23, 2024 at 5:57 PM
Here's a picture of my current lab (graduate students Luke Schaffer, Jeremy Lawrence, Sophie Breunig and my postdoc Dr. Isy Foote). We are a collaborative, productive, and nice group and I hope you'll consider joining us!
Students in my lab have an interest in at least one of the research areas listed above, but are not required to engage in research in all areas. Information on how to apply can be found here. Due date for applications is November 15th.
www.colorado.edu/psych-neuro/...
www.colorado.edu/psych-neuro/...
Faculty Recruiting Graduate Students
Recruitment Plans for Fall 2025 Prospective grad
www.colorado.edu
September 23, 2024 at 5:53 PM
Students in my lab have an interest in at least one of the research areas listed above, but are not required to engage in research in all areas. Information on how to apply can be found here. Due date for applications is November 15th.
www.colorado.edu/psych-neuro/...
www.colorado.edu/psych-neuro/...
4. One more! Preprint from graduate student Jeremy Lawrence that looks at the links between a wide-range of physical and psychiatric disorders. Findings include that substance use disorders, MDD, and ADHD are as associated with medical traits as with psychiatric. www.medrxiv.org/content/10.1...
Shared Genetic Liability across Systems of Psychiatric and Physical Illness
medRxiv - The Preprint Server for Health Sciences
www.medrxiv.org
August 7, 2024 at 6:02 PM
4. One more! Preprint from graduate student Jeremy Lawrence that looks at the links between a wide-range of physical and psychiatric disorders. Findings include that substance use disorders, MDD, and ADHD are as associated with medical traits as with psychiatric. www.medrxiv.org/content/10.1...
3. IBG graduate student Luke Schaffer investigated the genetic signal in autism spectrum disorder (ASD) that is unique of ADHD. Findings reveal clinical correlates, genes, and biological pathways unique to ASD: www.ncbi.nlm.nih.gov/pmc/articles...
Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by atypical patterns of social functioning and repetitive/restricted behaviors. ASD commonly co-occurs with ADHD and, des...
www.ncbi.nlm.nih.gov
July 25, 2024 at 6:14 PM
3. IBG graduate student Luke Schaffer investigated the genetic signal in autism spectrum disorder (ASD) that is unique of ADHD. Findings reveal clinical correlates, genes, and biological pathways unique to ASD: www.ncbi.nlm.nih.gov/pmc/articles...
2. IBG graduate student Sophie Breunig examined genetic links between immune-mediated and psychiatric factors. Findings reveal unique psychiatric links for factors defined by autoimmune vs autoinflammatory diseases: www.medrxiv.org/content/10.1...
Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders
medRxiv - The Preprint Server for Health Sciences
www.medrxiv.org
July 25, 2024 at 6:13 PM
2. IBG graduate student Sophie Breunig examined genetic links between immune-mediated and psychiatric factors. Findings reveal unique psychiatric links for factors defined by autoimmune vs autoinflammatory diseases: www.medrxiv.org/content/10.1...