Preprint: www.biorxiv.org/content/10.1...

Portal and gallery: www.e11.bio/tech

Addgene constructs: www.addgene.org/depositor-co...

Volara: github.com/e11bio/volara

Open data: github.com/e11bio/e11-o...

In our first study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x – with a clear path to 100x or more. They also permit tracing across spatial gaps – essential for mitigating tissue section loss in whole-brain scaling.

We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. This is the heart of PRISM. We integrated this capability with microscopy and AI image analysis to automatically trace neurons at high resolution and annotate them with molecular features.

Preprint: www.biorxiv.org/content/10.1...

Portal and gallery: www.e11.bio/tech

Addgene constructs: www.addgene.org/depositor-co...

Volara: github.com/e11bio/volara

Open data: github.com/e11bio/e11-o...

In our first study, we acquired a unique dataset in mouse hippocampus. Barcodes improved the accuracy of tracing genetically labelled neurons by 8x–with a clear path to 100x or more. They also permit tracing across spatial gaps–essential for mitigating tissue section loss in whole-brain scaling.

PRISM uses molecular ID codes and AI to help neurons trace themselves. We discovered a new cell barcoding approach exceeding comparable methods by more than 750x. We integrated this with microscopy and AI image analysis to automatically trace neurons at high resolution with molecular features.

Hi Monica, I'm working on a non-profit open science project for brain connectome mapping. Would love to be added to the science feed. scholar.google.com/citations?us...