Andrea Tricco
@andreatricco.bsky.social
Executive Director & Tier 1 Canada Research Chair, Li Ka Shing Knowledge Institute; Full Professor, University of Toronto; Co-Editor in Chief, Journal of Clinical Epidemiology
Reposted by Andrea Tricco
The new GRADE Guidance on using RCTs and NRSIs in evidence synthesis is out in JCE. Years of diagrams and domain debates distilled into a practical roadmap. If you work in guidelines or HTA, this one’s for you.
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
GRADE guidance 44: Strategies to enhance the utilization of randomized and non-randomized studies in evidence syntheses of health interventions
Ideally, guideline developers and HTA authors base intervention decisions on randomized
controlled trials (RCTs). However, relying solely on RCTs is uncommon, especially
for public health intervention...
www.jclinepi.com
November 22, 2025 at 4:27 PM
The new GRADE Guidance on using RCTs and NRSIs in evidence synthesis is out in JCE. Years of diagrams and domain debates distilled into a practical roadmap. If you work in guidelines or HTA, this one’s for you.
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
#GRADE #EvidenceSynthesis #SystematicReview #HTA
www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
This infographic captures the full process in a single view.
November 22, 2025 at 4:27 PM
This infographic captures the full process in a single view.
Reposted by Andrea Tricco
#CochraneDaily Just published! Scoping review of 165 studies maps factors associated with citation rates and reasons for and extent of citation bias in the health literature
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
www.jclinepi.com
November 26, 2025 at 9:21 AM
#CochraneDaily Just published! Scoping review of 165 studies maps factors associated with citation rates and reasons for and extent of citation bias in the health literature
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
www.jclinepi.com/article/S089...
#Bias #Citation
@jclinepi.bsky.social
Reposted by Andrea Tricco
Commentary: The many roles of decision thresholds for primary research, evidence synthesis and health decision-making - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Commentary: The many roles of decision thresholds for primary research, evidence synthesis and health decision-making
A decision threshold (DT) reflects the point at which a decision or judgment changes,
leading to the selection of an action or a commitment for one of several alternatives.
Thresholds have always play...
www.jclinepi.com
November 26, 2025 at 5:31 PM
Commentary: The many roles of decision thresholds for primary research, evidence synthesis and health decision-making - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Methodological Guidance for Individual Participant Data Meta-Analyses: A Systematic Review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Methodological Guidance for Individual Participant Data Meta-Analyses: A Systematic Review
To systematically identify and synthesize methodological guidance for conducting IPD-MAs
of randomized trials and observational studies, to inform the development of a critical
appraisal tool for repo...
www.jclinepi.com
November 26, 2025 at 5:32 PM
Methodological Guidance for Individual Participant Data Meta-Analyses: A Systematic Review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
The RoB-VE Project: Introduction to a methodological initiative to improve risk-of-bias assessment and reporting in #vaccine effectiveness research - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
The RoB-VE Project: Introduction to a methodological initiative to improve risk-of-bias assessment and reporting in vaccine effectiveness research
Vaccine effectiveness (VE) studies are essential for informing immunization policy
and public health decision-making. However, the observational nature of most VE studies
introduces unique methodologi...
www.jclinepi.com
November 26, 2025 at 5:33 PM
The RoB-VE Project: Introduction to a methodological initiative to improve risk-of-bias assessment and reporting in #vaccine effectiveness research - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
GRADE guidance 44: Strategies to enhance the utilization of randomized and non-randomized studies in evidence syntheses of health interventions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
GRADE guidance 44: Strategies to enhance the utilization of randomized and non-randomized studies in evidence syntheses of health interventions
Ideally, guideline developers and HTA authors base intervention decisions on randomized
controlled trials (RCTs). However, relying solely on RCTs is uncommon, especially
for public health intervention...
www.jclinepi.com
November 26, 2025 at 5:33 PM
GRADE guidance 44: Strategies to enhance the utilization of randomized and non-randomized studies in evidence syntheses of health interventions - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Hill’s Considerations Are Not Causal Criteria - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Hill’s Considerations Are Not Causal Criteria
Hill’s list of considerations for assessing causality, proposed 60 years ago, became
a landmark in the interpretation of epidemiologic evidence. However, it has been and
continues to be misused as a l...
www.jclinepi.com
November 26, 2025 at 5:34 PM
Hill’s Considerations Are Not Causal Criteria - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Discrimination, calibration, and variable importance in statistical and machine learning models for predicting overall survival in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Discrimination, calibration, and variable importance in statistical and machine learning models for predicting overall survival in advanced non-small cell lung cancer patients treated with immune chec...
Prognostic models can enhance clinician-patient communication and guide treatment
decisions. Numerous machine learning (ML) algorithms are available and offer a novel
approach to predicting survival i...
www.jclinepi.com
November 26, 2025 at 5:37 PM
Discrimination, calibration, and variable importance in statistical and machine learning models for predicting overall survival in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
The loss of efficacy of fluoxetine in pediatric depression: explanations, lack of acknowledgment, and implications for other treatments - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
The loss of efficacy of fluoxetine in pediatric depression: explanations, lack of acknowledgment, and implications for other treatments
Fluoxetine is among the most used antidepressants for children and adolescents and
frequently recommended as first-line pharmacological treatment for pediatric depression.
However, in contrast to earl...
www.jclinepi.com
November 26, 2025 at 5:38 PM
The loss of efficacy of fluoxetine in pediatric depression: explanations, lack of acknowledgment, and implications for other treatments - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Approaches for reporting and interpreting statistically nonsignificant findings in evidence syntheses: A systematic review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Approaches for reporting and interpreting statistically nonsignificant findings in evidence syntheses: A systematic review
To systematically review approaches for reporting and interpreting statistically nonsignificant
findings with clinical relevance in evidence synthesis, and to assess their methodological
quality and t...
www.jclinepi.com
November 26, 2025 at 5:38 PM
Approaches for reporting and interpreting statistically nonsignificant findings in evidence syntheses: A systematic review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Including nonrandomized evidence in living systematic reviews: lessons learned from the COVID-NMA initiative - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Including nonrandomized evidence in living systematic reviews: lessons learned from the COVID-NMA initiative
Randomized controlled trials (RCTs) are more likely to be included in evidence syntheses
of health interventions due to their methodological rigor. However, the integration
of nonrandomized studies (N...
www.jclinepi.com
November 26, 2025 at 5:39 PM
Including nonrandomized evidence in living systematic reviews: lessons learned from the COVID-NMA initiative - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
A Scoping Review of Critical Appraisal Tools and User Guides for Systematic Reviews with Network Meta-Analysis: Methodological Gaps and Directions for Tool Development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
A Scoping Review of Critical Appraisal Tools and User Guides for Systematic Reviews with Network Meta-Analysis: Methodological Gaps and Directions for Tool Development
Systematic reviews (SR) with network meta-analyses (NMA) are increasingly used to
inform guidelines, health technology assessments, and policy decisions. Their methodological
complexity, as well as th...
www.jclinepi.com
November 26, 2025 at 5:40 PM
A Scoping Review of Critical Appraisal Tools and User Guides for Systematic Reviews with Network Meta-Analysis: Methodological Gaps and Directions for Tool Development - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Use of structured tools by peer reviewers of systematic reviews: a cross-sectional study reveals high familiarity with PRISMA but limited use of other tools - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Use of structured tools by peer reviewers of systematic reviews: a cross-sectional study reveals high familiarity with PRISMA but limited use of other tools
Systematic reviews (SRs) are pivotal to evidence-based medicine. Structured tools
exist to guide their reporting and appraisal, such as PRISMA and AMSTAR. However,
there is limited data on whether pee...
www.jclinepi.com
November 26, 2025 at 5:40 PM
Use of structured tools by peer reviewers of systematic reviews: a cross-sectional study reveals high familiarity with PRISMA but limited use of other tools - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Guideline Organizations’ Guidance Documents Paper 4: Interest-holder engagement - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 4: Interest-holder engagement
Interest-holder engagement is increasingly recognized as essential to the relevance
and uptake of practice guidelines. “Interest-holders” are groups with legitimate interests
in the health issue under...
www.jclinepi.com
November 26, 2025 at 5:41 PM
Guideline Organizations’ Guidance Documents Paper 4: Interest-holder engagement - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Guideline Organizations’ Methods Handbooks Paper 9: Cooperative Approaches - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Methods Handbooks Paper 9: Cooperative Approaches
Collaboration allows participants to share and leverage their strengths, mitigating
resource limitations and duplication of efforts. Guideline-producing organizations
interested in collaboration have ...
www.jclinepi.com
November 26, 2025 at 5:41 PM
Guideline Organizations’ Methods Handbooks Paper 9: Cooperative Approaches - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Guideline Organizations’ Guidance Documents Paper 6: Adaptation of Practice Guidelines - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 6: Adaptation of Practice Guidelines
Developing high-quality practice guidelines is resource-intensive, leading many guideline-producing
organizations to adapt existing recommendations. The objective of this paper is to
describe processe...
www.jclinepi.com
November 26, 2025 at 5:41 PM
Guideline Organizations’ Guidance Documents Paper 6: Adaptation of Practice Guidelines - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Guideline Organizations’ Guidance Documents Paper 7: Updating Practice Guidelines - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 7: Updating Practice Guidelines
Practice guidelines play a crucial role in patient care and policymaking, making it
essential that they remain current and reflect the latest evidence. This study describes
the processes used by guide...
www.jclinepi.com
November 26, 2025 at 5:42 PM
Guideline Organizations’ Guidance Documents Paper 7: Updating Practice Guidelines - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Guideline Organizations’ Guidance Documents Paper 1: Introduction - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 1: Introduction
Given the role of practice guidelines in impacting practice and health outcomes, it
is important that their development follows rigorous methodology. We present a series
of papers exploring various as...
www.jclinepi.com
November 26, 2025 at 5:42 PM
Guideline Organizations’ Guidance Documents Paper 1: Introduction - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Guideline Organizations’ Guidance Documents Paper 5: Conflict of Interest and Funding - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 5: Conflict of Interest and Funding
Bias in the development process of practice guidelines can be introduced through contributors’
conflicts of interest and the funding sources. The objective of this study was to
describe policies of gu...
www.jclinepi.com
November 26, 2025 at 5:43 PM
Guideline Organizations’ Guidance Documents Paper 5: Conflict of Interest and Funding - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
Guideline Organizations’ Guidance Documents Paper 10: Developing Recommendations About Diagnostic Tests and Strategies - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Guideline Organizations’ Guidance Documents Paper 10: Developing Recommendations About Diagnostic Tests and Strategies
Diagnostic tests are central to clinical decision-making, but the rigor and consistency
of guidelines that inform their use remain unclear. This study aimed to describe processes
for developing recomm...
www.jclinepi.com
November 26, 2025 at 5:43 PM
Guideline Organizations’ Guidance Documents Paper 10: Developing Recommendations About Diagnostic Tests and Strategies - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
User experiences of qualitative evidence in the GRADE Evidence-to-Decision framework – Findings from Malawi, Nigeria and South Africa. - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
User experiences of qualitative evidence in the GRADE Evidence-to-Decision framework – Findings from Malawi, Nigeria and South Africa.
www.jclinepi.com
November 26, 2025 at 5:43 PM
User experiences of qualitative evidence in the GRADE Evidence-to-Decision framework – Findings from Malawi, Nigeria and South Africa. - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
Reposted by Andrea Tricco
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Please share: Save the date for the next KT Canada Summer Institute!
The 2026 Summer Institute will be in Ottawa, Ontario from June 8-10.
This year, there will be an option to stay another day and participate in the inaugural Ottawa Evidence to Action Showcase event!
#ImpSci
Please share: Save the date for the next KT Canada Summer Institute!
The 2026 Summer Institute will be in Ottawa, Ontario from June 8-10.
This year, there will be an option to stay another day and participate in the inaugural Ottawa Evidence to Action Showcase event!
#ImpSci
November 27, 2025 at 5:30 PM
(1/2)
Please share: Save the date for the next KT Canada Summer Institute!
The 2026 Summer Institute will be in Ottawa, Ontario from June 8-10.
This year, there will be an option to stay another day and participate in the inaugural Ottawa Evidence to Action Showcase event!
#ImpSci
Please share: Save the date for the next KT Canada Summer Institute!
The 2026 Summer Institute will be in Ottawa, Ontario from June 8-10.
This year, there will be an option to stay another day and participate in the inaugural Ottawa Evidence to Action Showcase event!
#ImpSci
Reposted by Andrea Tricco
Co-designed with our Knowledge Translation Committee, this resource aims to:
- Share research activities and findings with various audiences
- Increase awareness and promote meaningful change in research and practice
#KnowledgeMobilization
- Share research activities and findings with various audiences
- Increase awareness and promote meaningful change in research and practice
#KnowledgeMobilization
November 27, 2025 at 7:43 PM
Co-designed with our Knowledge Translation Committee, this resource aims to:
- Share research activities and findings with various audiences
- Increase awareness and promote meaningful change in research and practice
#KnowledgeMobilization
- Share research activities and findings with various audiences
- Increase awareness and promote meaningful change in research and practice
#KnowledgeMobilization
Reposted by Andrea Tricco
Conçue en collaboration avec notre comité d’application des connaissances, cette ressource vise à :
- Présenter les activités et les résultats de recherche avec divers publics
- Sensibiliser le public et promouvoir les changements positifs dans la recherche et la pratique
- Présenter les activités et les résultats de recherche avec divers publics
- Sensibiliser le public et promouvoir les changements positifs dans la recherche et la pratique
November 27, 2025 at 7:45 PM
Conçue en collaboration avec notre comité d’application des connaissances, cette ressource vise à :
- Présenter les activités et les résultats de recherche avec divers publics
- Sensibiliser le public et promouvoir les changements positifs dans la recherche et la pratique
- Présenter les activités et les résultats de recherche avec divers publics
- Sensibiliser le public et promouvoir les changements positifs dans la recherche et la pratique