Andre Rendeiro
@andre-rendeiro.com
Principal Investigator at CeMM and LBI-NetMed: https://rendeiro.group
Computational Biology of Aging and Pathology
Computational Biology of Aging and Pathology
Aging reshapes local tissue interactions but most organs retain a resilient overall architecture.
Our atlas provides a new framework to study tissue structure, resilience, and aging.
🔬 Learn more: rendeiro.group
Our atlas provides a new framework to study tissue structure, resilience, and aging.
🔬 Learn more: rendeiro.group
October 15, 2025 at 6:33 AM
Aging reshapes local tissue interactions but most organs retain a resilient overall architecture.
Our atlas provides a new framework to study tissue structure, resilience, and aging.
🔬 Learn more: rendeiro.group
Our atlas provides a new framework to study tissue structure, resilience, and aging.
🔬 Learn more: rendeiro.group
Among 100+ biological and clinical factors, age was the main driver of microanatomical changes.
About 27% of domains shift in abundance over adulthood, yet others remain remarkably stable.
About 27% of domains shift in abundance over adulthood, yet others remain remarkably stable.
October 15, 2025 at 6:33 AM
Among 100+ biological and clinical factors, age was the main driver of microanatomical changes.
About 27% of domains shift in abundance over adulthood, yet others remain remarkably stable.
About 27% of domains shift in abundance over adulthood, yet others remain remarkably stable.
We developed H&E-UTAG, an unsupervised method that detects recurrent microanatomical domains directly from H&E slides.
It identified 218 domains across 40 tissues and 29 organs — revealing how cellular organization underlies organ function.
It identified 218 domains across 40 tissues and 29 organs — revealing how cellular organization underlies organ function.
October 15, 2025 at 6:32 AM
We developed H&E-UTAG, an unsupervised method that detects recurrent microanatomical domains directly from H&E slides.
It identified 218 domains across 40 tissues and 29 organs — revealing how cellular organization underlies organ function.
It identified 218 domains across 40 tissues and 29 organs — revealing how cellular organization underlies organ function.
New work from Iva Buljan @ivabuljan.bsky.social in our lab!
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
October 15, 2025 at 6:29 AM
New work from Iva Buljan @ivabuljan.bsky.social in our lab!
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
We mapped how human tissue architecture changes with age using ~25k histology slides from 983 donors.
This is the first body-wide atlas of human microanatomy.
📄 Preprint: www.biorxiv.org/content/10.1...
Great to be at the 2025 @OeGMBT meeting in Innsbruck and hear the diverse research made by the local community, in particular by the young researchers who presented their work.
Thank you to the organizers, and to Markus Mandl for the invitation to talk!
Thank you to the organizers, and to Markus Mandl for the invitation to talk!
September 26, 2025 at 6:58 PM
Great to be at the 2025 @OeGMBT meeting in Innsbruck and hear the diverse research made by the local community, in particular by the young researchers who presented their work.
Thank you to the organizers, and to Markus Mandl for the invitation to talk!
Thank you to the organizers, and to Markus Mandl for the invitation to talk!
Congratulations to Lisa Kleissl in our group, who won the best short talk award at the FEBS Advanced Course on Immunology, metabolism and ageing in Matrei am Brenner, Austria!
September 12, 2025 at 8:20 AM
Congratulations to Lisa Kleissl in our group, who won the best short talk award at the FEBS Advanced Course on Immunology, metabolism and ageing in Matrei am Brenner, Austria!
Our group is in Gumpoldskirchen, Austria, for our first lab retreat!
It is a fantastic opportunity to get together and discuss our research projects, share ideas, and engage in some team building. A big thank you to everyone in the team, who together make it a privilege and honor to do this job.
It is a fantastic opportunity to get together and discuss our research projects, share ideas, and engage in some team building. A big thank you to everyone in the team, who together make it a privilege and honor to do this job.
September 3, 2025 at 4:19 PM
Our group is in Gumpoldskirchen, Austria, for our first lab retreat!
It is a fantastic opportunity to get together and discuss our research projects, share ideas, and engage in some team building. A big thank you to everyone in the team, who together make it a privilege and honor to do this job.
It is a fantastic opportunity to get together and discuss our research projects, share ideas, and engage in some team building. A big thank you to everyone in the team, who together make it a privilege and honor to do this job.
LazySlide 🦥 just hit 100 GitHub stars! 🎉 Our free, open-source framework is making whole slide analysis easier than ever. Built on scverse 🐍, it handles everything from tissue segmentation to multi-omics workflows 🤹 & deep learning 🏋️. Big thanks to the community!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 16, 2025 at 12:31 PM
LazySlide 🦥 just hit 100 GitHub stars! 🎉 Our free, open-source framework is making whole slide analysis easier than ever. Built on scverse 🐍, it handles everything from tissue segmentation to multi-omics workflows 🤹 & deep learning 🏋️. Big thanks to the community!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🔬 Whole slide histopathology images are a goldmine for tissue biology and diagnostics - but too often locked away in inaccessible formats or tools. In our new preprint, we introduce LazySlide: an open-source, modular, and interoperable framework.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 1, 2025 at 6:49 PM
🔬 Whole slide histopathology images are a goldmine for tissue biology and diagnostics - but too often locked away in inaccessible formats or tools. In our new preprint, we introduce LazySlide: an open-source, modular, and interoperable framework.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🚨 Only a few days left to apply! 🚨
Join our interdisciplinary lab through the CeMM PhD Program! We're hiring PhD students in computational and systems biology.
📄 Learn more & apply: apply.cemm.at
Join our interdisciplinary lab through the CeMM PhD Program! We're hiring PhD students in computational and systems biology.
📄 Learn more & apply: apply.cemm.at
January 17, 2025 at 2:44 PM
🚨 Only a few days left to apply! 🚨
Join our interdisciplinary lab through the CeMM PhD Program! We're hiring PhD students in computational and systems biology.
📄 Learn more & apply: apply.cemm.at
Join our interdisciplinary lab through the CeMM PhD Program! We're hiring PhD students in computational and systems biology.
📄 Learn more & apply: apply.cemm.at
Yimin's paper on a a novel visualization paradigm and implementation of cross-layout visualizations is now published in the journal Genome Biology (genomebiology.biomedcentral.com/articles/10....). Check it out at github.com/Marsilea-viz...
January 7, 2025 at 8:23 AM
Yimin's paper on a a novel visualization paradigm and implementation of cross-layout visualizations is now published in the journal Genome Biology (genomebiology.biomedcentral.com/articles/10....). Check it out at github.com/Marsilea-viz...
Thank you to our friends @gmivienna.bsky.social for the very nice and on point Arabidopsis histology-inspired season greetings, happy holidays!
December 16, 2024 at 8:20 AM
Thank you to our friends @gmivienna.bsky.social for the very nice and on point Arabidopsis histology-inspired season greetings, happy holidays!
Proud of Iva Buljan, PhD student in the lab, who gave a talk and presented a poster at the inaugural meeting of the European Society for Spatial Biology in Berlin, Germany last week!
December 16, 2024 at 8:16 AM
Proud of Iva Buljan, PhD student in the lab, who gave a talk and presented a poster at the inaugural meeting of the European Society for Spatial Biology in Berlin, Germany last week!
Ejner Molten @ Austrian personalized medicine conference: data [harmonization, sharing, annotation, ...] is the largest barrier to personalized medicine implementation in Europe
December 3, 2024 at 12:23 PM
Ejner Molten @ Austrian personalized medicine conference: data [harmonization, sharing, annotation, ...] is the largest barrier to personalized medicine implementation in Europe
Our lab had a lot of fun last night doing an escape room adventure and trying out new food at a Spanish tapas restaurant. More news at: rendeiro.group/news/
November 28, 2024 at 10:43 AM
Our lab had a lot of fun last night doing an escape room adventure and trying out new food at a Spanish tapas restaurant. More news at: rendeiro.group/news/
As rich as these insights are, many tissues are not accessible in the real world. We combined the image-based age predictions with blood gene expression data, resulting in new blood biological age predictors that are tissue-specific! These were higher in individuals with disease
November 16, 2024 at 3:15 PM
As rich as these insights are, many tissues are not accessible in the real world. We combined the image-based age predictions with blood gene expression data, resulting in new blood biological age predictors that are tissue-specific! These were higher in individuals with disease
But not all tissues, organs or individuals age in the same way. Tissue-specific clocks allowed us to identify waves of accelerated aging, classify individuals by their most aged organs, and demographic, lifestyle and clinical associations with specific acceleration of organs.
November 16, 2024 at 3:15 PM
But not all tissues, organs or individuals age in the same way. Tissue-specific clocks allowed us to identify waves of accelerated aging, classify individuals by their most aged organs, and demographic, lifestyle and clinical associations with specific acceleration of organs.
From these deep tissue features, we build biological age clocks with mean prediction error of 4.9 years, which are associated with telomere length, subclinical pathologies, and comorbidities. Tissue structure tell us more about biological age than chronological age!
November 16, 2024 at 3:15 PM
From these deep tissue features, we build biological age clocks with mean prediction error of 4.9 years, which are associated with telomere length, subclinical pathologies, and comorbidities. Tissue structure tell us more about biological age than chronological age!
We fine-tune #deeplearning models on healthy human tissue images, which enables us to augment them with super rich features highlighting and quantifying various aspects of tissue biology across scales in a systematic manner.
November 16, 2024 at 3:15 PM
We fine-tune #deeplearning models on healthy human tissue images, which enables us to augment them with super rich features highlighting and quantifying various aspects of tissue biology across scales in a systematic manner.
The GTEx project, with over 25,000 images of healthy tissue from almost 1000 individuals provides a phenomenal resource to address these questions www.nature.com/articles/ng....
November 16, 2024 at 3:15 PM
The GTEx project, with over 25,000 images of healthy tissue from almost 1000 individuals provides a phenomenal resource to address these questions www.nature.com/articles/ng....
For many human tissues it is not known how molecular and cellular aging changes lead to the decline of physiological function. This work is a step towards the systematic quantification of the aging process in human tissues at scale.
November 16, 2024 at 3:15 PM
For many human tissues it is not known how molecular and cellular aging changes lead to the decline of physiological function. This work is a step towards the systematic quantification of the aging process in human tissues at scale.
What if we could look at a human tissue image🔬and quantify its biological age?🧬 And how could we get the same insights without collecting the tissue sample? In our new @biorxivpreprint, we create "tissue clocks" ⏳to do just that! www.biorxiv.org/content/10.1... 📝 #aging #tissue thread below⬇️
November 16, 2024 at 3:15 PM
What if we could look at a human tissue image🔬and quantify its biological age?🧬 And how could we get the same insights without collecting the tissue sample? In our new @biorxivpreprint, we create "tissue clocks" ⏳to do just that! www.biorxiv.org/content/10.1... 📝 #aging #tissue thread below⬇️
The new Center for Translational Medicine of the Medical University of Vienna boasts a very impressive building facade: Klimt's Medicine - congratulations on the bold choice and importance of restoring this artwork to a place of significance 👏
November 15, 2024 at 6:44 PM
The new Center for Translational Medicine of the Medical University of Vienna boasts a very impressive building facade: Klimt's Medicine - congratulations on the bold choice and importance of restoring this artwork to a place of significance 👏
Ernesto Abila presenting his poster on profiling cell aging cells in histopathological images at the Frontiers in Single Cell Genomics meeting organized by Cold Spring Harbor Asia in Japan🧬🔬
November 13, 2024 at 7:52 AM
Ernesto Abila presenting his poster on profiling cell aging cells in histopathological images at the Frontiers in Single Cell Genomics meeting organized by Cold Spring Harbor Asia in Japan🧬🔬
Excited with our new NVIDIA H100 GPUs now up and running in our HGX nodes at CeMM! Thanks a lot to the IT team! This will supercharge our computational power and accelerate breakthroughs in human health and aging research🧬
October 9, 2024 at 6:54 AM
Excited with our new NVIDIA H100 GPUs now up and running in our HGX nodes at CeMM! Thanks a lot to the IT team! This will supercharge our computational power and accelerate breakthroughs in human health and aging research🧬