Andrea Testa
@andre-head.bsky.social
He/Him | TPD Biotech startup (#2)👷🧬📈 Scientist🔬 Medicinal chemistry⚗️ Chemical biology🧪| musician🎹🎶 | weightlifter 🏋️| 🇮🇹🏴🏳️🌈
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Andrea Testa
@andre-head.bsky.social
· Jan 2
Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andrea Testa
Meet our Senior Director of Chemistry, Dr Andrea Testa, and discover his journey in targeted protein degradation research in this blog: trimtechtherapeutics.com/meet-the-tea...
November 5, 2025 at 10:44 AM
Meet our Senior Director of Chemistry, Dr Andrea Testa, and discover his journey in targeted protein degradation research in this blog: trimtechtherapeutics.com/meet-the-tea...
Reposted by Andrea Testa
Today's Bioorganic bingo 😂
June 17, 2025 at 1:06 PM
Today's Bioorganic bingo 😂
Reposted by Andrea Testa
In two important ways Labour empowered Nigel Farage and Faragism this week. Both were strategic mistakes. We’ve seen this story before.
New writing from me.
open.substack.com/pub/goodalla...
New writing from me.
open.substack.com/pub/goodalla...
Labour seems determined to elevate Farage and Faragism- they should stop.
And why Starmer is "better"at foreign policy than domestic
open.substack.com
May 16, 2025 at 4:19 PM
In two important ways Labour empowered Nigel Farage and Faragism this week. Both were strategic mistakes. We’ve seen this story before.
New writing from me.
open.substack.com/pub/goodalla...
New writing from me.
open.substack.com/pub/goodalla...
Not a bad commute to work.. 🚲
April 14, 2025 at 8:23 PM
Not a bad commute to work.. 🚲
Nice timing to introduce @trimtech.bsky.social on this platform! Learn more about @trimtech.bsky.social foundational science here:
Very excited for our next seminar this Thursday, March 20th:
Martin Schwalm (@thesgc.bsky.social, formerly Knapp lab) will share insights on UPS inhibitors and Dean Clift (TRIMTECH Tx) will discuss hijacking TRIM21 for protein #degradation!
👉Join us at 12 PM EST/ 5 pm CET (‼️ US/EU time mismatch ‼️)
Martin Schwalm (@thesgc.bsky.social, formerly Knapp lab) will share insights on UPS inhibitors and Dean Clift (TRIMTECH Tx) will discuss hijacking TRIM21 for protein #degradation!
👉Join us at 12 PM EST/ 5 pm CET (‼️ US/EU time mismatch ‼️)
March 18, 2025 at 8:03 PM
Nice timing to introduce @trimtech.bsky.social on this platform! Learn more about @trimtech.bsky.social foundational science here:
Reposted by Andrea Testa
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
A Bifunctional Degrader Reads Out in Phase 3
www.science.org
March 12, 2025 at 6:53 PM
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
January 2, 2025 at 4:26 PM
Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Wishing everyone a happy new year, pushing forward our science, hobbies and passions, surrounded by people we enjoy spending time with!
January 1, 2025 at 8:52 PM
Wishing everyone a happy new year, pushing forward our science, hobbies and passions, surrounded by people we enjoy spending time with!
Amazing work!! Congratulations @alessiociulli.bsky.social and @alesalerno.bsky.social 💡🥂
🚨 Exciting News! 🚨
What happens when unconventional ideas drive to push boundaries? 🚀 Meet FerroTACs: a novel #PROTAC design using ferrocene as core unit to re-imagining linker design and fine-tune their phys-chem properties. Learn more about our work led by @alesalerno.bsky.social here: 🧪👇 1/5
What happens when unconventional ideas drive to push boundaries? 🚀 Meet FerroTACs: a novel #PROTAC design using ferrocene as core unit to re-imagining linker design and fine-tune their phys-chem properties. Learn more about our work led by @alesalerno.bsky.social here: 🧪👇 1/5
December 22, 2024 at 12:51 AM
Amazing work!! Congratulations @alessiociulli.bsky.social and @alesalerno.bsky.social 💡🥂
Reposted by Andrea Testa
Happy to share our UBR4 structures. Check out the preprint to see how this giant E4 ligase complex selects substrates for ubiquitin chain extension. We also look at conservation and adaptations across humans, nematodes and plants.
www.biorxiv.org/content/10.1...
@clausenlab.bsky.social
www.biorxiv.org/content/10.1...
@clausenlab.bsky.social
December 21, 2024 at 9:13 AM
Happy to share our UBR4 structures. Check out the preprint to see how this giant E4 ligase complex selects substrates for ubiquitin chain extension. We also look at conservation and adaptations across humans, nematodes and plants.
www.biorxiv.org/content/10.1...
@clausenlab.bsky.social
www.biorxiv.org/content/10.1...
@clausenlab.bsky.social
Fantastic to see more ternary complex structures of #PROTACs recruiting novel E3 ligases!! www.nature.com/articles/s41...
Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity - Nature Communications
The authors show that DCAF1, a substrate receptor of CUL4 and EDVP E3 ligases, can be recruited by PROTACs to degrade the cancer drug target, WDR5. They also report the crystal structures of PROTAC te...
www.nature.com
November 24, 2024 at 11:08 AM
Fantastic to see more ternary complex structures of #PROTACs recruiting novel E3 ligases!! www.nature.com/articles/s41...
First post on here, on my way back from a fantastic #TPD conference in Shenzhen, China. Great science and a level of engagement well above expectations! Thanks for having me!!
November 15, 2024 at 4:56 AM
First post on here, on my way back from a fantastic #TPD conference in Shenzhen, China. Great science and a level of engagement well above expectations! Thanks for having me!!