@anandgururajan.bsky.social
Paper of the week by my last PhD student, Morgan Bucknor! Morgan's research focused on developing a triple-hit murine model of NDDs and used a range of high-res tech to examine the impact on transcriptome and proteome in brain and blood! Super proud! www.biorxiv.org/content/10.1...
March 21, 2025 at 12:56 AM
Paper of the week by my last PhD student, Morgan Bucknor! Morgan's research focused on developing a triple-hit murine model of NDDs and used a range of high-res tech to examine the impact on transcriptome and proteome in brain and blood! Super proud! www.biorxiv.org/content/10.1...
Reposted
My brain, oh my brain, tell me what drugs I'm on!
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression
www.nature.com/articles/s41...
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression
www.nature.com/articles/s41...
February 13, 2025 at 10:59 AM
My brain, oh my brain, tell me what drugs I'm on!
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression
www.nature.com/articles/s41...
Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression
www.nature.com/articles/s41...
Paper of the week: "A molecular mechanism mediating clozapine-enhanced sensorimotor gating." Really nice paper, starting with basic behavioural phenotyping, then gradually using more complex techniques. www.nature.com/articles/s41...
February 14, 2025 at 2:27 AM
Paper of the week: "A molecular mechanism mediating clozapine-enhanced sensorimotor gating." Really nice paper, starting with basic behavioural phenotyping, then gradually using more complex techniques. www.nature.com/articles/s41...
Paper of the week: "Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC." onlinelibrary.wiley.com/doi/10.1111/...
February 7, 2025 at 12:46 AM
Paper of the week: "Transcriptomic Regulation by Astrocytic m6A Methylation in the mPFC." onlinelibrary.wiley.com/doi/10.1111/...
Reposted
Being patient with the biology of addiction
Advancing laboratory discoveries into treatments is taking decades for cancer, and doing so for addiction will take longer, given the brain’s far greater complexity
www.science.org/doi/10.1126/...
Advancing laboratory discoveries into treatments is taking decades for cancer, and doing so for addiction will take longer, given the brain’s far greater complexity
www.science.org/doi/10.1126/...
February 6, 2025 at 2:57 PM
Being patient with the biology of addiction
Advancing laboratory discoveries into treatments is taking decades for cancer, and doing so for addiction will take longer, given the brain’s far greater complexity
www.science.org/doi/10.1126/...
Advancing laboratory discoveries into treatments is taking decades for cancer, and doing so for addiction will take longer, given the brain’s far greater complexity
www.science.org/doi/10.1126/...
Paper of the week: "Dorsal BNST GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice." Activation induces depressive-like behaviours, inhibition alleviates CUS-induced depressive-like behaviours. www.sciencedirect.com/science/arti...
January 31, 2025 at 6:55 AM
Paper of the week: "Dorsal BNST GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice." Activation induces depressive-like behaviours, inhibition alleviates CUS-induced depressive-like behaviours. www.sciencedirect.com/science/arti...
Reposted
Already a lot of great discussion of this paper on here, but the enrichment of neuropsychiatric disease burden genes in "eccentric" MSNs is really intriguing to me.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mapping the cellular etiology of schizophrenia and complex brain phenotypes - Nature Neuroscience
Duncan and colleagues link specific human brain cell types to schizophrenia and other complex brain phenotypes, providing mechanistic insights and a cellular taxonomy for psychiatric disorders.
www.nature.com
January 22, 2025 at 11:24 PM
Already a lot of great discussion of this paper on here, but the enrichment of neuropsychiatric disease burden genes in "eccentric" MSNs is really intriguing to me.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Paper of the week: "Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward." Loss of vNut in the female nAC leads to increased FST immobility and decreased sucrose preference. www.nature.com/articles/s41...
Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward - Molecular Psychiatry
Molecular Psychiatry - Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward
www.nature.com
January 23, 2025 at 11:47 PM
Paper of the week: "Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward." Loss of vNut in the female nAC leads to increased FST immobility and decreased sucrose preference. www.nature.com/articles/s41...
My paper of the week: "The modified elevated gap interaction test: a novel paradigm to assess social preference." royalsocietypublishing.org/doi/10.1098/...
December 19, 2024 at 12:35 AM
My paper of the week: "The modified elevated gap interaction test: a novel paradigm to assess social preference." royalsocietypublishing.org/doi/10.1098/...
"Multi-level therapeutic actions of cannabidiol in ketamine-induced schizophrenia psychopathology in male rats." It's been more than a decade since I did my PhD on CBD. This is amazing work identifying MOA for CBD's therapeutic potential.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 12, 2024 at 10:52 PM
"Multi-level therapeutic actions of cannabidiol in ketamine-induced schizophrenia psychopathology in male rats." It's been more than a decade since I did my PhD on CBD. This is amazing work identifying MOA for CBD's therapeutic potential.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
Teacher: What is the first rule of thermodynamics?
Me: We don't talk about thermodynamics
Me: We don't talk about thermodynamics
December 4, 2024 at 8:50 PM
Teacher: What is the first rule of thermodynamics?
Me: We don't talk about thermodynamics
Me: We don't talk about thermodynamics
"Understanding the neural code of stress to control anhedonia." Very cool paper showing role of CA1-BLA circuit in mediating response to stress. www.nature.com/articles/s41...
Understanding the neural code of stress to control anhedonia - Nature
Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to s...
www.nature.com
December 5, 2024 at 12:35 AM
"Understanding the neural code of stress to control anhedonia." Very cool paper showing role of CA1-BLA circuit in mediating response to stress. www.nature.com/articles/s41...
Watching the West Wing for the second time round. Would not have thought it would make so emotional. For the times in which we live in, watching the series gives me hope. #westwing
November 29, 2024 at 8:23 AM
Watching the West Wing for the second time round. Would not have thought it would make so emotional. For the times in which we live in, watching the series gives me hope. #westwing