@anagq.bsky.social
Reposted
I am happy to share our latest publication.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acids encircling the double helix, ensuring a sufficiently stable association during base interrogation while avoiding excessive engagement detrimental for fast scanning.
dlvr.it
February 12, 2026 at 9:33 AM
I am happy to share our latest publication.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.