Maximilien Martinez
@maximil1.bsky.social
I am happy to share our latest publication.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acids encircling the double helix, ensuring a sufficiently stable association during base interrogation while avoiding excessive engagement detrimental for fast scanning.
dlvr.it
February 12, 2026 at 9:33 AM
I am happy to share our latest publication.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
In this work, we show that OGG1 association with DNA during lesion search involves local DNA distortion promoting base unstacking. This process is tightly controlled by conserved residues to ensure stable association without compromising fast scanning.
Reposted by Maximilien Martinez
Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Filament formation and NAD processing by noncanonical human FAM118 sirtuins - Nature Structural & Molecular Biology
Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that FAM118A/B processing of NAD involves head-to-tail filament...
www.nature.com
November 17, 2025 at 6:17 PM
Please check our collaborative paper with Marcin Suskiewicz and Sebastien Huet labs on FAM118 proteins – non-canonical sirtuins that form filaments and act as NADases in human and other vertebrate cells.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Maximilien Martinez
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1. https://www.biorxiv.org/content/10.1101/2025.10.08.681224v1
October 9, 2025 at 2:33 AM
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1. https://www.biorxiv.org/content/10.1101/2025.10.08.681224v1
Reposted by Maximilien Martinez
#JEOL CRYO ARM™ 200 #CryoEM installed at the Institute Genetics & Development of Rennes.
First installation of this type of instrument in France and incorporates the latest technologies in cryo contrast enhancement and dual-axis #tomography.
We wish IGDR success with their future research projects.
First installation of this type of instrument in France and incorporates the latest technologies in cryo contrast enhancement and dual-axis #tomography.
We wish IGDR success with their future research projects.
April 16, 2025 at 9:05 AM
#JEOL CRYO ARM™ 200 #CryoEM installed at the Institute Genetics & Development of Rennes.
First installation of this type of instrument in France and incorporates the latest technologies in cryo contrast enhancement and dual-axis #tomography.
We wish IGDR success with their future research projects.
First installation of this type of instrument in France and incorporates the latest technologies in cryo contrast enhancement and dual-axis #tomography.
We wish IGDR success with their future research projects.