Amy W Chung
@amywchung.bsky.social
Scientist studying Antibody responses against Infectious Diseases, COVID-19, HIV, Influenza, Malaria, TB. Coffee addict, Foodie, Feline enthusiast
Pinned
Amy W Chung
@amywchung.bsky.social
· Mar 1
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant
Elevated SARS-CoV-2–specific IgG4 titers decrease ADCC but can increase ADCP when spike-specific antibody titers are low.
www.science.org
Excited to share new work by PhD student Carissa Aurelia that examines the functional impact of IgG4 from repeated mRNA vaccination in Sci Adv. www.science.org/doi/10.1126/... 🙏🏼 @kev-in-science.bsky.social @ruthamypurcell.bsky.social @viralvaxlab.bsky.social @thedohertyinst.bsky.social
Reposted by Amy W Chung
Happy to have the latest @amywchung.bsky.social lab preprint online! 🦠 Here we demonstrated that systemic inflammation in solid tumor malignancy patients was associated with impaired SARS-CoV-2 neutralizing antibody functions while non-neutralizing functions remained robust (yay Fc functions!) 🦠
Dysregulated inflammation in solid tumor malignancy patients shapes polyfunctional antibody responses to COVID-19 vaccination https://www.medrxiv.org/content/10.1101/2025.05.09.25327344v1
May 12, 2025 at 10:08 AM
Happy to have the latest @amywchung.bsky.social lab preprint online! 🦠 Here we demonstrated that systemic inflammation in solid tumor malignancy patients was associated with impaired SARS-CoV-2 neutralizing antibody functions while non-neutralizing functions remained robust (yay Fc functions!) 🦠
Reposted by Amy W Chung
Nice summary and discussion about our recent IgG4 publication that just came out on #scienceadvances from @amywchung.bsky.social lab (kudos to our PhD candidate Carissa Aurelia 👩🔬🎉)
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪
#immunosky #IDsky #medsky 🧪
I know everyone missed thinking about IgG4, but we have a new study that finds some very interesting properties of anti-spike IgG4 elicited by mRNA vaccines
tl;dr- IgG4 seems to buffer inflammation but enhances the function of other antibodies when titers are lower
🧵
I know everyone missed thinking about IgG4, but we have a new study that finds some very interesting properties of anti-spike IgG4 elicited by mRNA vaccines
tl;dr- IgG4 seems to buffer inflammation but enhances the function of other antibodies when titers are lower
🧵
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant
Elevated SARS-CoV-2–specific IgG4 titers decrease ADCC but can increase ADCP when spike-specific antibody titers are low.
www.science.org
March 1, 2025 at 8:38 AM
Nice summary and discussion about our recent IgG4 publication that just came out on #scienceadvances from @amywchung.bsky.social lab (kudos to our PhD candidate Carissa Aurelia 👩🔬🎉)
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪
Glad it has answered some technical questions and raised more for future work/discussion 🧐🔬🧪
Excited to share new work by PhD student Carissa Aurelia that examines the functional impact of IgG4 from repeated mRNA vaccination in Sci Adv. www.science.org/doi/10.1126/... 🙏🏼 @kev-in-science.bsky.social @ruthamypurcell.bsky.social @viralvaxlab.bsky.social @thedohertyinst.bsky.social
Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant
Elevated SARS-CoV-2–specific IgG4 titers decrease ADCC but can increase ADCP when spike-specific antibody titers are low.
www.science.org
March 1, 2025 at 9:35 AM
Excited to share new work by PhD student Carissa Aurelia that examines the functional impact of IgG4 from repeated mRNA vaccination in Sci Adv. www.science.org/doi/10.1126/... 🙏🏼 @kev-in-science.bsky.social @ruthamypurcell.bsky.social @viralvaxlab.bsky.social @thedohertyinst.bsky.social