For every 1 Swiss franc invested in ETH Zurich, Switzerland gets 5-6 francs back

Source: ethz.ch/staffnet/en/...

Innate Immune Memory is Stimulus Specific

Memory can persist in #macrophages for at least 11 days (in vitro)

Rather than activating a universal training state, different stimuli impart specific memories that generate distinct training phenotypes in #macrophages

www.biorxiv.org/content/10.1...

Endocrine gland size is proportional to its target tissue size

• Amazing work from Uri Alon's group showing that hormone secreting and total target cell numbers are proportional

• One endocrine cell (Sender) serves about 2,000 target cells (Receivers)

www.cell.com/iscience/ful...

Matrix viscoelasticity enhances stem cell differentiation in hydrogels via nuclear mechanotransduction

#Mechanobiology

www.nature.com/articles/s41...

100%

which reminded me of @ardemp.bsky.social rule #1 on how to science: Don’t be too busy

Being too busy (with noise) = less time to read papers, less time to think and to connect the dots, less time for creative work!

Wideband laser speckle rheological microscopy reveals the viscoelastic landscape of biological tissues with high spatial resolution (25 micrometers) 👏

www.science.org/doi/10.1126/...

#Mechanobiology

Mechanobiology of 3D cell confinement and extracellular crowding

Excellent review from Céline Labouesse's group at @ETHZurich.bsky.social. #Mechanobiology

link.springer.com/article/10.1...

Dynamic hydrogel biomaterials reveal that skeletal muscle stem cells harbor a mechanical memory | PNAS

www.pnas.org/doi/10.1073/...

#Mechanobiology

Matrix viscoelasticity promotes cell expansion and migration | PNAS

www.pnas.org/doi/epdf/10....

#Mechanobiology

Macrophage memories of early-life injury drive neonatal nociceptive priming

“Macrophages are both necessary and partially sufficient to drive neonatal nociceptive priming (i.e. Pain memory), possibly due to a long-lasting remodeling in chromatin structure.”

www.cell.com/cell-reports...

Epigenetic mechanisms of metabolic memory

“Targeting epigenetic factors using small molecules or locus-specific epigenetic editing are potential approaches to prevent or treat diabetic kidney disease and erase metabolic memory.” 💥

www.nature.com/articles/s41...

🇨🇭🏔🍂

Non-invasive imaging of tissue mechanics

Excellent work by the Shapiro lab & co. describing hybrid magneto-gas vesicles nanostructures as contrast agents for US-based, non-invasive & long-term measurements of tissue elasticity in vivo. #Mechanobiology

www.nature.com/articles/s41...

Pathological mechanics aggravate cartilage damage

#Mechanical imbalance leads to abnormal joint loading, release of #alarmins from osteoclasts, pro-inflammatory activation of fibroblasts & macrophages, and ultimately cartilage injury.

nature.com/articles/s41...

Macrophage immune memory in inflammatory arthritis

"Pro-inflammatory cytokines, DAMPs & PAMPS constitute triggers that induce metabolic and epigenetic reprogramming, leading to #macrophage memory in inflammatory arthritis."

nature.com/articles/s41...

Obesity confers #macrophage memory

◽️Obesity triggers epigenetic reprogramming of innate immune cells, which lasts long after return to normal weight

◽️Stearic fatty acid (via TLR4) remodels chromatin & ↑AP-1 accessibility

◽️MΦ shift OXPHOS→ glycolysis

science.org/doi/10.1126/...