Amro Hussien
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amrohussien.bsky.social
Amro Hussien
@amrohussien.bsky.social
HFSP/EMBO Fellow @MaxPlanck.de (Wickström Lab) | Prev. @ETHZ.ch‬, @UCL.ac.uk |

First-principles in: #Mechanobiology • #EpigeneticMemories • #Inflammation • #Tendon
Reposted by Amro Hussien
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...
November 13, 2025 at 10:05 PM
Reposted by Amro Hussien
A couple of years ago, a smattering of A.I. tracks went viral for using tricks like replicating the voices of pop stars, including Jay-Z and Drake. Now we’re in the midst of a full-blown A.I. music moment, @chaykak writes. https://newyorkermag.visitlink.me/m6CdDF
That New Hit Song on Spotify? It Was Made by A.I.
Aspiring musicians are churning out tracks using generative artificial intelligence. Some are topping the charts.
newyorkermag.visitlink.me
November 13, 2025 at 6:00 PM
Reposted by Amro Hussien
“Even when I was an assistant professor, I would say things like, ‘I’m a researcher.’ I wouldn’t say I’m a scientist.” Nobel Laureate Ardem Patapoutian made groundbreaking discoveries about the sense of touch. But he didn’t always have a sense of belonging in science.
Even Nobel Prize Winners Deal With Imposter Syndrome
Neuroscientist Ardem Patapoutian immigrated to the US, found belonging in science, and did groundbreaking work on sense of touch.
buff.ly
November 11, 2025 at 7:13 PM
Reposted by Amro Hussien
🚀 Exciting news! ERC Synergy Grant of €8.5 million to Sara Wickström @sarawickstrom.bsky.social, Daniel St Jonston @gurdoninstitute.bsky.social and Ewa Paluch @universitypress.cambridge.org! This highly interdisciplinary project will boost our understanding of tissue biology. #ERCSyG @erc.europa.eu
November 6, 2025 at 11:21 AM
Reposted by Amro Hussien
Research | Amiad Pavlov, Heffler et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic target.

doi.org/10.1038/s441...

rdcu.be/eOeTA
Microtubule forces drive nuclear damage in LMNA cardiomyopathy - Nature Cardiovascular Research
Amiad Pavlov, Heffler, et al. demonstrate that stress transmitted to the cardiomyocyte nucleus by the microtubule cage drives LMNA-associated cardiomyopathy and may represent a promising therapeutic t...
doi.org
November 4, 2025 at 2:56 PM
Reposted by Amro Hussien
Broad has launched the Biology of Adversity Project, led by
@jbuenrostro.bsky.social a 2023 @macfound.org fellow, to uncover how adverse life experiences can inflict molecular “scars” in the genome and body and increase risk of heart disease and other disorders. Learn more: broad.io/BAP
November 4, 2025 at 4:26 PM
Reposted by Amro Hussien
NEW from me:

Political hostility, high visa fees and (in the case of the UK) stagnant incomes are making the UK and US less attractive destinations for top international talent.

That steep decline in the appeal of moving to the US after 2016 is 👀
October 31, 2025 at 2:32 PM
Reposted by Amro Hussien
At #EMBC2025, Dame Molly Stevens shared how bioengineered materials are transforming healthcare - from affordable diagnostics to advanced therapeutics and regenerative medicine.

🔗 https://www.youtube.com/watch?v=id8x8f8IcDU?utm_source=bluesky&utm_medium=social

#Bioengineering #Biomaterials
Next-Gen Biomaterials in Medicine with Prof. Dame Molly Stevens | EMBC 2025 Interview by EMBS TV
From early disease detection to advanced therapies, bioengineering and nanomaterials are revolutionizing medicine. In this exclusive EMBC 2025 interview, Professor Dame Molly Stevens, a world leader in biomaterials research, shares how her team is developing innovative materials that improve diagnostics, enable regenerative medicine, and create smarter therapeutics. Discover how these breakthroughs are making healthcare more accessible worldwide, reducing diagnostic costs, and shaping the future of personalized medicine. Plus, learn why interdisciplinary collaboration across chemistry, physics, and computer science is key to solving some of the most complex health challenges. What You'll Learn in This Video: ✔ How biomaterials improve disease detection and therapy ✔ The role of nanotechnology in regenerative medicine ✔ Why affordability and accessibility in diagnostics matter ✔ Cutting-edge research in brain-interactive materials ✔ The vision for the next decade of bioengineering innovation Timestamps: 00:00 Introduction 00:18 Meet Professor Molly Stevens 00:30 How biomaterials impact healthcare 01:05 Ensuring equal access to diagnostics 01:53 Next-generation diagnostics and affordability 02:29 Future outlook: Advanced therapies and brain-interactive materials #BiomedicalEngineering #BioMaterials #Nanotechnology #HealthcareInnovation #EMBC2025 #MedicalDiagnostics #RegenerativeMedicine #IEEEEMBS
youtu.be
October 8, 2025 at 6:47 PM
Reposted by Amro Hussien
Excited to share our new paper in Nature Communications! We show how Piezo1 and the molecular clutch work together to sense viscoelastic cues in stem cells. Grateful to my mentors and co-authors from @uofglasgow.bsky.social & @ibecbarcelona.eu who made this possible! Check it out: rdcu.be/eK8d4
Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity
Nature Communications - Matrix viscoelasticity regulates cell behavior in a stiffness-dependent manner. Here, the authors reveal that the mechanosensitive channel Piezo1 transduces soft matrix...
rdcu.be
October 17, 2025 at 5:12 PM
Reposted by Amro Hussien
RESEARCH | G Wang, M Giera, @trabelink.bsky.social et al (LUMC)

Workflow: Perform quantitative MS imaging and provide insight into spatial metabolic remodeling in ischemic mouse brains 🧪
Spatial quantitative metabolomics enables identification of remote and sustained ipsilateral cortical metabolic reprogramming after stroke - Nature Metabolism
Wang et al. report a workflow to perform quantitative mass spectrometry imaging and provide insight into spatial metabolic remodelling undergone in the mouse brain upon ischaemia.
bit.ly
October 11, 2025 at 4:00 PM
Reposted by Amro Hussien
The surprisingly lifelike behavior of inanimate chemicals & systems forces us to reconsider our assumptions about where minds reside, @conorfeehly.bsky.social writes.

#biology #cognition #chemistry #ool
The Surprisingly Lifelike Behavior Of Mindless Material | NOEMA
New ways of studying the origin of life are leading to a better understanding of consciousness and the mind.
www.noemamag.com
October 9, 2025 at 5:24 PM
Reposted by Amro Hussien
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
Reposted by Amro Hussien
Gene-editing tools transform cells into record-keepers, capturing hidden timelines of health and disease

go.nature.com/4pBRRlh
Real-time molecular recorders expose the inner lives of cells
Gene-editing tools transform cells into record-keepers, capturing hidden timelines of health and disease.
go.nature.com
September 22, 2025 at 5:39 PM
Reposted by Amro Hussien
We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics.

We applied this workflow to map precancerous lesions of the fallopian tubes.

More here: www.biorxiv.org/content/10.1...
September 22, 2025 at 11:48 AM
Reposted by Amro Hussien
The Federal Council wants to cut costs in the ERI sector despite widespread objections. Cuts of over 10 percent per year are planned for the SNSF over the next few years. Above all, this plan jeopardises the innovation potential and competitiveness of the Swiss economy. ⤵️ www.snf.ch/en/9a7Fhnojt...
The SNSF urges against cuts
In its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent.
www.snf.ch
September 19, 2025 at 12:46 PM
Reposted by Amro Hussien
Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.
September 18, 2025 at 6:12 PM
Reposted by Amro Hussien
In this Viewpoint, Adam Zweifach explains how to calculate how many cells to analyze per sample to achieve reasonable statistical power in #microscopy experiments. rupress.org/jcb/article/...

📕 In #Reproducibility and Best Practices in Cell Biology: rupress.org/jcb/collecti...
September 18, 2025 at 2:03 PM
Reposted by Amro Hussien
We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.

mikeinmemoriam.sciencesconf.org
September 18, 2025 at 8:50 AM
Reposted by Amro Hussien
📢 📢📢📢 📢 Mechanosensitive fibroblasts fuel strictures via YAP/TAZ signaling—opening doors to new anti-fibrotic therapies. Grateful to be part of this transformative study with the Longaker lab! 🙏🙏🙏
www.sciencedirect.com/science/arti...
STAY TUNED for more in IBD damage from the #Naiklab
Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures
A significant complication of Crohn’s disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the…
www.sciencedirect.com
September 17, 2025 at 4:13 PM
Reposted by Amro Hussien
Nature research paper: Energy deficiency selects crowded live epithelial cells for extrusion

go.nature.com/42tmu2l
Energy deficiency selects crowded live epithelial cells for extrusion - Nature
Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.
go.nature.com
September 15, 2025 at 7:57 AM
Reposted by Amro Hussien
Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions | Science Advances www.science.org/doi/10.1126/...
Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions
This work demonstrates that changes in the nonlinear elasticity of collagen in hybrid networks tunes cell-matrix interactions.
www.science.org
September 4, 2025 at 4:11 PM
Reposted by Amro Hussien
Our new preprint is out!
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing

Full story & movies👇
Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social@masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...
August 28, 2025 at 3:11 PM
Reposted by Amro Hussien
Researchers can now study the dynamics of embryo implantation using a platform amenable to live fluorescence imaging and traction force microscopy.

This work in #ScienceAdvances may offer new ways to view implantation failure. https://scim.ag/4oQ6xwN
August 27, 2025 at 5:55 PM
Reposted by Amro Hussien
🧪 From petri dish to embryo model: @jacob-hanna.bsky.social work shows how naïve pluripotent stem cells can self-organize into advanced developmental stages.
The 2025 #HFSPNakasoneAward lecture reveals the science behind synthetic embryo models.

Full lecture 🎥 👉 zurl.co/Tgf4f
#sts
HFSP Nakasone Award 2025 Lecture – Jacob Hanna on Synthetic Embryo Models
In this official HFSP Nakasone Award lecture, Professor Jacob (Yaqub) Hanna of the Weizmann Institute of Science shares the groundbreaking research that earn...
www.youtube.com
August 14, 2025 at 8:14 AM
Reposted by Amro Hussien
A 2024 Science study in mice identifies chromatin plasticity as a novel form of plasticity important for information encoding.

Learn more in this #SciencePerspective: scim.ag/3HgM6bt #ScienceMagArchives
August 1, 2025 at 7:56 PM