Amitabh C. Pandey
@amitabhcpandey.bsky.social
Assistant Professor physician-scientist cardiologist, translational & clinical researcher, @tulanedom, @tulanemedicine
Reposted by Amitabh C. Pandey
A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics - Nature Communications
Single-cell RNAseq can struggle to capture cellular heterogeneity due to the relatively low expression of biologically meaningful transcripts. Here the authors present an approach called scCLEAN, whic...
www.nature.com
May 30, 2025 at 12:53 PM
A CRISPR/Cas9-based enhancement of high-throughput single-cell transcriptomics
www.nature.com/articles/s41...
www.nature.com/articles/s41...
We also find that using scCLEAN allows improved resolution for cellular biologic processes. This includes #vascular biology where nuanced #vsmc heterogeneity can be seen whereas traditional scRNAseq analysis would not. @tulanemedicine.bsky.social @tulaneu.bsky.social @scripps.edu
May 20, 2025 at 11:13 AM
We also find that using scCLEAN allows improved resolution for cellular biologic processes. This includes #vascular biology where nuanced #vsmc heterogeneity can be seen whereas traditional scRNAseq analysis would not. @tulanemedicine.bsky.social @tulaneu.bsky.social @scripps.edu