Aske Merrild
@amerrild.bsky.social
Reposted by Aske Merrild
Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin-like Lasso Peptide https://www.biorxiv.org/content/10.64898/2025.12.02.691826v1
December 6, 2025 at 2:45 AM
Biosynthesis, Structure, and Antibiotic Properties of Gelatinamin A, a Triculamin-like Lasso Peptide https://www.biorxiv.org/content/10.64898/2025.12.02.691826v1
Thanks for a great colab Marc!
Out today in Angewandte Chemie
Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides
doi.org/10.1002/anie...
Fun collaboration with the Tørring lab
@thomastorring.bsky.social @tizianasvenningsen.bsky.social @amerrild.bsky.social
Evolution-Guided Discovery of Antimycobacterial Triculamin-Like Lasso Peptides
doi.org/10.1002/anie...
Fun collaboration with the Tørring lab
@thomastorring.bsky.social @tizianasvenningsen.bsky.social @amerrild.bsky.social
Evolution‐Guided Discovery of Antimycobacterial Triculamin‐Like Lasso Peptides
Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene ...
doi.org
February 21, 2025 at 5:27 PM
Thanks for a great colab Marc!
>80 grams of engineered lasso peptide from 20 L E. Coli fermentation broth. This and more amazing results from Lassogen in preprint.
Overcoming Immune Checkpoint Inhibitor Resistance via Potent and Selective Dual αvβ6/8 Inhibitors Based on Engineered Lasso Peptides https://www.biorxiv.org/content/10.1101/2025.01.28.635346v1
February 2, 2025 at 11:42 PM
>80 grams of engineered lasso peptide from 20 L E. Coli fermentation broth. This and more amazing results from Lassogen in preprint.
Reposted by Aske Merrild
We are excited to see our review published! In it, we explore the diversity of enzymatic strategies for installing aromatic side chain cross-links in RiPPs. If you like interesting chemistry and new enzyme reactions, be sure to check it out!
A Review from Sanath Kandy, Michael Pasquale, and Jonathan Chekan highlights newly discovered enzymes responsible for aromatic side-chain crosslinking in ribosomally synthesized and post-translationally modified peptides (RiPPs)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Aromatic side-chain crosslinking in RiPP biosynthesis - Nature Chemical Biology
Aromatic side-chain crosslinking is emerging as a widespread and biosynthetically diverse feature in the RiPP natural products. This Review summarizes and unifies recent advancements, focusing on key ...
www.nature.com
January 16, 2025 at 6:30 PM
We are excited to see our review published! In it, we explore the diversity of enzymatic strategies for installing aromatic side chain cross-links in RiPPs. If you like interesting chemistry and new enzyme reactions, be sure to check it out!
Reposted by Aske Merrild
I’m not entirely sure how these starter packs work…
but I’ve created one for microbial natural products - hopefully it helps us connect! go.bsky.app/72NeGsT
but I’ve created one for microbial natural products - hopefully it helps us connect! go.bsky.app/72NeGsT
October 19, 2024 at 8:37 PM
I’m not entirely sure how these starter packs work…
but I’ve created one for microbial natural products - hopefully it helps us connect! go.bsky.app/72NeGsT
but I’ve created one for microbial natural products - hopefully it helps us connect! go.bsky.app/72NeGsT
Reposted by Aske Merrild
A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin
Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene c...
www.biorxiv.org
December 22, 2024 at 9:52 AM
A Christmas present to all of the lasso peptide connoisseurs out there. The next chapter in our work is on triculamin is ready on bioRxiv. Great work by two incredibly talented graduate students @amerrild.bsky.social and @tizianasvenningsen.bsky.social.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...