Alvin X Han
@alvinxhan.bsky.social
Infectious Disease Modeller • Assistant Professor at Amsterdam University Medical Centers
We have a new paper out led by the exceptional Simon De Jong in our group: While mobility-driven competition leads to highly structured spread of influenza viruses, predictability of national epidemics is limited by variability in short-term epidemiological processes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Competition between transmission lineages mediated by human mobility shapes seasonal influenza epidemics in the US - Nature Communications
Leveraging genomic and epidemiological surveillance data, the authors show that flu epidemics in the US arise from independent outbreaks in different states that spread from state to state through com...
www.nature.com
May 21, 2025 at 8:44 AM
We have a new paper out led by the exceptional Simon De Jong in our group: While mobility-driven competition leads to highly structured spread of influenza viruses, predictability of national epidemics is limited by variability in short-term epidemiological processes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alvin X Han
Our consortium's paper on Mpox in West Africa is finally out today: "Genomics reveals zoonotic and sustained human Mpox spread in West Africa" rdcu.be/emGKq. Extremely fortunately to get to work with such an exceptional team of African public health scientists, and our partners!
Genomics reveals zoonotic and sustained human Mpox spread in West Africa
Nature - Genomics reveals zoonotic and sustained human Mpox spread in West Africa
rdcu.be
May 19, 2025 at 4:58 PM
Our consortium's paper on Mpox in West Africa is finally out today: "Genomics reveals zoonotic and sustained human Mpox spread in West Africa" rdcu.be/emGKq. Extremely fortunately to get to work with such an exceptional team of African public health scientists, and our partners!
Reposted by Alvin X Han
Perspective on Immunological drivers of zoonotic virus emergence, evolution, and endemicity, written with some of my favourite people. Read it before its thoughtcrime! authors.elsevier.com/c/1ks2e3qNrU...
Online now: Immunological drivers of zoonotic virus emergence, evolution, and endemicity
Immunological drivers of zoonotic virus emergence, evolution, and endemicity
In this perspective, Andersen and colleagues examine how host immunity shapes the emergence, evolution, and persistence of novel and emerging viruses. They highlight the role of antibody-driven selection in viral adaptation and endemicity, emphasizing research priorities that integrate immunological insights with surveillance and vaccine strategies to improve pandemic preparedness.
dlvr.it
April 1, 2025 at 9:08 AM
Perspective on Immunological drivers of zoonotic virus emergence, evolution, and endemicity, written with some of my favourite people. Read it before its thoughtcrime! authors.elsevier.com/c/1ks2e3qNrU...
Reposted by Alvin X Han
Comment by Florian Krammer and coll. calling for strengthening European flu research - very timely in several ways!
New comment:
Europe needs a sustainably funded influenza research and response network
www.thelancet.com/journals/lan...
Europe needs a sustainably funded influenza research and response network
www.thelancet.com/journals/lan...
Europe needs a sustainably funded influenza research and response network
Influenza viruses have caused four pandemics during the last century.1 The 1918 H1N1
pandemic claimed 20–50 million lives, the 1957 H2N2 pandemic and the 1968 H3N2 pandemic
claimed 1–4 million lives e...
www.thelancet.com
February 18, 2025 at 1:15 PM
Comment by Florian Krammer and coll. calling for strengthening European flu research - very timely in several ways!
As #birdflu fears rise, know that we already have antiviral drugs that can limit the impact of a future #influenza #pandemic. But they are only effective if governments consider #stockpiling now. We laid out several potential stockpiling options and considerations in our new preprint.
Our new preprint, out now, estimates the size of #influenza oral #antiviral #stockpile, including #BaloxavirMarboxil and #Oseltamivir, needed #globally during the early stages of a potential influenza #pandemic before the availability of vaccines.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Estimating the global demand and potential public health impact of oral antiviral treatment stockpile for influenza pandemics: a mathematical modelling study
Background Oral influenza antiviral drugs could potentially minimize the disease burden of a nascent influenza pandemic prior to the availability of vaccines. Mathematical modelling is useful for desi...
www.medrxiv.org
February 17, 2025 at 2:42 AM
As #birdflu fears rise, know that we already have antiviral drugs that can limit the impact of a future #influenza #pandemic. But they are only effective if governments consider #stockpiling now. We laid out several potential stockpiling options and considerations in our new preprint.
Our new preprint, out now, estimates the size of #influenza oral #antiviral #stockpile, including #BaloxavirMarboxil and #Oseltamivir, needed #globally during the early stages of a potential influenza #pandemic before the availability of vaccines.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Estimating the global demand and potential public health impact of oral antiviral treatment stockpile for influenza pandemics: a mathematical modelling study
Background Oral influenza antiviral drugs could potentially minimize the disease burden of a nascent influenza pandemic prior to the availability of vaccines. Mathematical modelling is useful for desi...
www.medrxiv.org
February 12, 2025 at 12:37 PM
Our new preprint, out now, estimates the size of #influenza oral #antiviral #stockpile, including #BaloxavirMarboxil and #Oseltamivir, needed #globally during the early stages of a potential influenza #pandemic before the availability of vaccines.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...