Alpha-gal Syndrome Research
@alphagal-res.bsky.social
Sharing research on alpha-gal syndrome (AGS) and related topics. Tweets≠medical advice.
More papers here:
https://alphagalinformation.org/publications-database/
#alphagal #alphagalsyndrome #allergy #glycotime
More papers here:
https://alphagalinformation.org/publications-database/
#alphagal #alphagalsyndrome #allergy #glycotime
"A potential link between AGS and eosinophilic gastrointestinal disorders is highlighted through this case."
journals.lww.com/ajg/fulltext...
journals.lww.com/ajg/fulltext...
journals.lww.com
October 31, 2025 at 9:31 PM
"A potential link between AGS and eosinophilic gastrointestinal disorders is highlighted through this case."
journals.lww.com/ajg/fulltext...
journals.lww.com/ajg/fulltext...
Immunologic investigation of an allergic transfusion reaction suspected due to alpha-gal syndrome
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pubmed.ncbi.nlm.nih.gov/40938245/
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pubmed.ncbi.nlm.nih.gov/40938245/
Immunologic investigation of an allergic transfusion reaction suspected due to alpha-gal syndrome - PubMed
We report a case of anaphylactic shock in an O patient transfused with a B platelet unit. The in vitro data suggest, but do not prove, that the reaction was mediated by recipient alpha-gal IgE. Furthe...
pubmed.ncbi.nlm.nih.gov
September 14, 2025 at 5:37 PM
Immunologic investigation of an allergic transfusion reaction suspected due to alpha-gal syndrome
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pubmed.ncbi.nlm.nih.gov/40938245/
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pubmed.ncbi.nlm.nih.gov/40938245/
From Poland:
Alpha-Gal Syndrome—A Series of Cases with Different Clinical Pictures
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www.mdpi.com/1422-0067/26...
Alpha-Gal Syndrome—A Series of Cases with Different Clinical Pictures
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www.mdpi.com/1422-0067/26...
www.mdpi.com
September 14, 2025 at 5:24 PM
From Poland:
Alpha-Gal Syndrome—A Series of Cases with Different Clinical Pictures
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www.mdpi.com/1422-0067/26...
Alpha-Gal Syndrome—A Series of Cases with Different Clinical Pictures
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www.mdpi.com/1422-0067/26...
A Case of Illness Following a Bite by a Male Lone Star Tick ( Amblyomma americanum Linnaeus) Infected With Ehrlichia sp. and Rickettsia amblyommatis in Connecticut, United States
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pmc.ncbi.nlm.nih.gov/articles/PMC...
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pmc.ncbi.nlm.nih.gov/articles/PMC...
A Case of Illness Following a Bite by a Male Lone Star Tick ( Amblyomma americanum Linnaeus) Infected With Ehrlichia sp. and Rickettsia amblyommatis in Connecticut, United States
The lone star tick ( Amblyomma americanum Linnaeus) is a species commonly found in the southeastern U.S., but in recent years its populations have expanded northward, resulting in an increased risk of...
pmc.ncbi.nlm.nih.gov
September 7, 2025 at 10:45 PM
A Case of Illness Following a Bite by a Male Lone Star Tick ( Amblyomma americanum Linnaeus) Infected With Ehrlichia sp. and Rickettsia amblyommatis in Connecticut, United States
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pmc.ncbi.nlm.nih.gov/articles/PMC...
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pmc.ncbi.nlm.nih.gov/articles/PMC...
The Role of Anisakis sp. in α-Gal Sensitization: Implications for Parasitic-Induced Meat Allergy
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pubmed.ncbi.nlm.nih.gov/40872299/
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pubmed.ncbi.nlm.nih.gov/40872299/
The Role of Anisakis sp. in α-Gal Sensitization: Implications for Parasitic-Induced Meat Allergy - PubMed
<span><b>Background/Objectives:</b> This study investigates the potential of <i>Anisakis</i> sp. as a novel source of α-Gal (Galα1-3Galβ1-4GlcNAc-R) epitopes capable of inducing allergic sensitization...
pubmed.ncbi.nlm.nih.gov
September 3, 2025 at 3:22 AM
The Role of Anisakis sp. in α-Gal Sensitization: Implications for Parasitic-Induced Meat Allergy
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pubmed.ncbi.nlm.nih.gov/40872299/
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pubmed.ncbi.nlm.nih.gov/40872299/
Alpha-Gal Syndrome Across the Lifespan: Distinct Pediatric Clinical Patterns and Rural Predominance in Midwestern Patients.
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www.annallergy.org/article/S108...
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www.annallergy.org/article/S108...
Alpha-Gal Syndrome Across the Lifespan: Distinct Pediatric Clinical Patterns and Rural Predominance in Midwestern Patients
Abbreviations: AGS (alpha-gal syndrome), IgE (immunoglobulin E), ICD (International
Classification of Diseases), HRSA (Health Resources and Services Administration)
www.annallergy.org
September 3, 2025 at 2:35 AM
Alpha-Gal Syndrome Across the Lifespan: Distinct Pediatric Clinical Patterns and Rural Predominance in Midwestern Patients.
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www.annallergy.org/article/S108...
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www.annallergy.org/article/S108...
Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab')2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area
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pubmed.ncbi.nlm.nih.gov/40817895/
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pubmed.ncbi.nlm.nih.gov/40817895/
Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab')2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area - PubMed
We demonstrate a substantial incidence of adverse drug reactions and presumed anaphylaxis to crotaline antivenoms in an α-GAL endemic region, with F(ab')<sub>2</sub> antivenom associated with more rea...
pubmed.ncbi.nlm.nih.gov
August 17, 2025 at 4:49 PM
Prevalence of Adverse Drug Reactions: Comparing Crotalidae Immune Polyvalent Antivenoms F(ab')2 and F(ab) in a Galactose-alpha-1,3-galactose (alpha-gal) Endemic Area
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pubmed.ncbi.nlm.nih.gov/40817895/
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pubmed.ncbi.nlm.nih.gov/40817895/
"Our findings support pre-treatment alpha-gal screening to improve safety of cetuximab therapy in high-risk populations."
pubmed.ncbi.nlm.nih.gov/40773826/
pubmed.ncbi.nlm.nih.gov/40773826/
A protocol for pre-treatment testing for antibodies to galactose-alpha-1,3-galactose to mitigate the risk of cetuximab hypersensitivity reactions - a retrospective cohort review - PubMed
Hypersensitivity reactions (HSRs) limit cetuximab use in KRAS wildtype advanced colorectal cancer, with a significant driver being pre-formed IgE antibodies against galactose-1,3-alpha-galactose (alph...
pubmed.ncbi.nlm.nih.gov
August 10, 2025 at 6:57 PM
"Our findings support pre-treatment alpha-gal screening to improve safety of cetuximab therapy in high-risk populations."
pubmed.ncbi.nlm.nih.gov/40773826/
pubmed.ncbi.nlm.nih.gov/40773826/
The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat (review article)
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
July 20, 2025 at 1:57 AM
The Immunology of Alpha-Gal Syndrome: History, Tick Bites, IgE, and Delayed Anaphylaxis to Mammalian Meat (review article)
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome: The Biomedical Excellence for Safer Transfusion Collaborative Study
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pubmed.ncbi.nlm.nih.gov/40643108/
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pubmed.ncbi.nlm.nih.gov/40643108/
ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome: The Biomedical Excellence for Safer Transfusion Collaborative Study - PubMed
Evidence supporting the possibility of a new adverse event, TRAGS, is accumulating. This study quantifies how often Group O patients may be exposed to Group B antigen in Group B or AB plasma and/or pl...
pubmed.ncbi.nlm.nih.gov
July 19, 2025 at 5:06 PM
ABO-mismatched platelet and plasma transfusion practices and the potential for transfusion-related alpha-gal syndrome: The Biomedical Excellence for Safer Transfusion Collaborative Study
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pubmed.ncbi.nlm.nih.gov/40643108/
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pubmed.ncbi.nlm.nih.gov/40643108/
Anti-Alpha-Gal Antibodies Against Gangliosides: A New Autoimmune Target in Alzheimer’s Disease Patients.
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www.preprints.org/frontend/man...
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www.preprints.org/frontend/man...
www.preprints.org
July 19, 2025 at 4:57 PM
Anti-Alpha-Gal Antibodies Against Gangliosides: A New Autoimmune Target in Alzheimer’s Disease Patients.
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www.preprints.org/frontend/man...
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www.preprints.org/frontend/man...
Reposted by Alpha-gal Syndrome Research
Moje uwagi na blogu @eksperymentmyslowy.bsky.social o alergii na czerwone mięso w wyniku ukąszenia przez kleszcza:
tinyurl.com/3pdb44sw
#glycotime
@alphagal-info.bsky.social
@alphagal-res.bsky.social
tinyurl.com/3pdb44sw
#glycotime
@alphagal-info.bsky.social
@alphagal-res.bsky.social
June 9, 2025 at 8:35 AM
Moje uwagi na blogu @eksperymentmyslowy.bsky.social o alergii na czerwone mięso w wyniku ukąszenia przez kleszcza:
tinyurl.com/3pdb44sw
#glycotime
@alphagal-info.bsky.social
@alphagal-res.bsky.social
tinyurl.com/3pdb44sw
#glycotime
@alphagal-info.bsky.social
@alphagal-res.bsky.social
"This report describes a case of prompt identification of AGS in a patient presenting for redo aortic valve replacement and examines the perioperative implications."
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www.jcvaonline.com/article/S105...
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www.jcvaonline.com/article/S105...
Perioperative Considerations for a Patient with Alpha-Gal Syndrome Undergoing Cardiac Surgery
Alpha-gal syndrome (AGS) was first described by Commins and Platts-Mills in 2009 as
an IgE-mediated allergic reaction to galactose-alpha-1,3-galactose (alpha-gal) residues
on nonprimate mammalian tiss...
www.jcvaonline.com
June 1, 2025 at 8:59 PM
"This report describes a case of prompt identification of AGS in a patient presenting for redo aortic valve replacement and examines the perioperative implications."
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www.jcvaonline.com/article/S105...
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www.jcvaonline.com/article/S105...
"This case emphasizes the need for a thorough differential diagnosis, particularly in regions where alpha-gal IgE antibodies are common. While AGS is plausible, alternative etiologies should be thoroughly considered ..."
jeccm.amegroups.org/article/view...
jeccm.amegroups.org/article/view...
Alpha-gal syndrome presenting in the emergency department: a case report
Alpha-gal syndrome presenting in the emergency department: a case report
jeccm.amegroups.org
May 30, 2025 at 10:30 PM
"This case emphasizes the need for a thorough differential diagnosis, particularly in regions where alpha-gal IgE antibodies are common. While AGS is plausible, alternative etiologies should be thoroughly considered ..."
jeccm.amegroups.org/article/view...
jeccm.amegroups.org/article/view...
"In a general suburban population individuals had 9% higher odds of being sensitized to α-gal the closer they lived to a forest supporting exposure to ticks as a risk factor for sensitization to α-gal." (Denmark, pre-proof)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Living close to the forest is a risk factor for galactose‐α‐1,3‐galactose sensitization.
The α-gal syndrome (AGS) is a food allergy towards galactose‐α‐1,3‐galactose (α‐gal) present in mammalian meat and it usually develops after tick bite…
www.sciencedirect.com
May 30, 2025 at 10:01 PM
"In a general suburban population individuals had 9% higher odds of being sensitized to α-gal the closer they lived to a forest supporting exposure to ticks as a risk factor for sensitization to α-gal." (Denmark, pre-proof)
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Not alpha-gal related, but fascinating and like AGS involves both glycobiology and allergy.
FASI investigator, Dr. Robert Anthony discovered that IgE antibodies in people with peanut allergies carry extra sugar molecules—specifically sialic acid & removing that sugar greatly reduced allergic responses.
pubmed.ncbi.nlm.nih.gov/32499653
#allergysky #immunosky #pedsky #foodallergy
pubmed.ncbi.nlm.nih.gov/32499653
#allergysky #immunosky #pedsky #foodallergy
May 15, 2025 at 10:57 PM
Not alpha-gal related, but fascinating and like AGS involves both glycobiology and allergy.
Alpha-gal syndrome as an occupational allergy: reactions in a meat packing facility.
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Case Report: Alpha Gal Syndrome
rdw.rowan.edu/stratford_re...
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Case Report: Alpha Gal Syndrome
rdw.rowan.edu/stratford_re...
Case Report: Alpha Gal Syndrome
We report a case of a 40-year-old male who presented with sensation of throat closing and shortness of breath while at work at a meat processing facility. The differential diagnosis of shortness of br...
rdw.rowan.edu
May 4, 2025 at 6:39 PM
Alpha-gal syndrome as an occupational allergy: reactions in a meat packing facility.
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Case Report: Alpha Gal Syndrome
rdw.rowan.edu/stratford_re...
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Case Report: Alpha Gal Syndrome
rdw.rowan.edu/stratford_re...
Optimizing α-Gal Epitope Removal in Porcine Dermal Matrix: Enzyme Selection and Tissue Form Matter
pubmed.ncbi.nlm.nih.gov/40314122/
pubmed.ncbi.nlm.nih.gov/40314122/
Optimizing α-Gal Epitope Removal in Porcine Dermal Matrix: Enzyme Selection and Tissue Form Matter - PubMed
Decellularization does not completely remove the matrix-bound α-Gal epitopes in porcine acellular dermal matrix (pADM), and the presence of residual α-Gal epitopes could elicit adverse immunological r...
pubmed.ncbi.nlm.nih.gov
May 4, 2025 at 5:43 PM
Optimizing α-Gal Epitope Removal in Porcine Dermal Matrix: Enzyme Selection and Tissue Form Matter
pubmed.ncbi.nlm.nih.gov/40314122/
pubmed.ncbi.nlm.nih.gov/40314122/
Public perspectives on tick bite exposure, healthcare visits and associated allergies in iberia
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pubmed.ncbi.nlm.nih.gov/40317252/
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pubmed.ncbi.nlm.nih.gov/40317252/
Public perspectives on tick bite exposure, healthcare visits and associated allergies in iberia - PubMed
This study provides valuable insights that should be considered to improve TBDs surveillance and diagnostic strategies, as well as developing preventive measures to reduce tick bite exposure and TBD c...
pubmed.ncbi.nlm.nih.gov
May 4, 2025 at 5:26 PM
Public perspectives on tick bite exposure, healthcare visits and associated allergies in iberia
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pubmed.ncbi.nlm.nih.gov/40317252/
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pubmed.ncbi.nlm.nih.gov/40317252/
Is Zebrafish a Good Model for the Alpha‐Gal Syndrome?
pubmed.ncbi.nlm.nih.gov/40317760/
pubmed.ncbi.nlm.nih.gov/40317760/
Is Zebrafish a Good Model for the Alpha-Gal Syndrome? - PubMed
The alpha-Gal syndrome (AGS) is an underdiagnosed tick-borne allergy characterized by both immediate and delayed IgE-mediated anaphylactic reactions to the galactose-alpha-1,3-galactose (alpha-Gal) ep...
pubmed.ncbi.nlm.nih.gov
May 4, 2025 at 4:32 PM
Is Zebrafish a Good Model for the Alpha‐Gal Syndrome?
pubmed.ncbi.nlm.nih.gov/40317760/
pubmed.ncbi.nlm.nih.gov/40317760/
"This article aims to highlight the unique characteristics of French Guiana (FG), where evidence suggests a high, hidden prevalence of Alpha-Gal Syndrome (AGS), offering opportunities to address several key questions"
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
French Guiana and AGS: a path to uncovering hidden clues
This article is a narrative review exploring how research in French Guiana could unlock the mysteries surrounding Alpha-Gal Syndrome (AGS), a recently identified IgE-mediated allergy with delayed r...
www.tandfonline.com
March 30, 2025 at 10:44 PM
"This article aims to highlight the unique characteristics of French Guiana (FG), where evidence suggests a high, hidden prevalence of Alpha-Gal Syndrome (AGS), offering opportunities to address several key questions"
www.tandfonline.com/doi/10.1080/...
www.tandfonline.com/doi/10.1080/...
The non-mandatory food allergens triggering anaphylaxis that we should not sweep under the carpet: data from the Allergy-Vigilance Network
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www.sciencedirect.com/science/arti...
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www.sciencedirect.com/science/arti...
The non-mandatory food allergens triggering anaphylaxis that we should not sweep under the carpet: data from the Allergy-Vigilance Network
The list of mandatory allergens provided by the European Regulation includes14 allergens but other foods are often involved in food-induced anaphylaxi…
www.sciencedirect.com
March 24, 2025 at 6:35 PM
The non-mandatory food allergens triggering anaphylaxis that we should not sweep under the carpet: data from the Allergy-Vigilance Network
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www.sciencedirect.com/science/arti...
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www.sciencedirect.com/science/arti...