Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
@allshire-lab.bsky.social
Professor, University of Edinburgh.
Science: epigenetics, variegation, heterochromatin, heteroresistance, resistance, bet hedging, fungal biology & pathogens. Pets: Airedale Terriers. Duolingo: 🇫🇷 level 61. Opinions here are my own
Science: epigenetics, variegation, heterochromatin, heteroresistance, resistance, bet hedging, fungal biology & pathogens. Pets: Airedale Terriers. Duolingo: 🇫🇷 level 61. Opinions here are my own
A lot of interest in QED Science as an automated review system linked to preprint servers. All we need now is funding level for authors to be somehow linked to the overall score provided by the AI and we can do away with grant writing and grant reviewing and panels. Cut the bureaucracy in science!
And you can of course also go through to the q.e.d website: www.qedscience.com
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
www.qedscience.com
November 11, 2025 at 8:46 AM
A lot of interest in QED Science as an automated review system linked to preprint servers. All we need now is funding level for authors to be somehow linked to the overall score provided by the AI and we can do away with grant writing and grant reviewing and panels. Cut the bureaucracy in science!
A big car park where the Darwin Building at King’s Building, University of Edinburgh used to be
September 8, 2025 at 10:44 AM
A big car park where the Darwin Building at King’s Building, University of Edinburgh used to be
The Darwin Building @edinburghup.bsky.social which housed the UK’s first Dept of Molecular Biology is no more! Many notable scientists worked their & passed through: 1968-2018. We look forward to a suitable replacement that promotes excellent biological research allowing many more key discoveries.
July 24, 2025 at 8:20 AM
The Darwin Building @edinburghup.bsky.social which housed the UK’s first Dept of Molecular Biology is no more! Many notable scientists worked their & passed through: 1968-2018. We look forward to a suitable replacement that promotes excellent biological research allowing many more key discoveries.
@edinburghairport.bsky.social What are you playing at? Delta 122 flight from Boston lands 06:30 Passengers have to wait on plane cos Customs hall does not open until 07:00 - Ridiculous get your act together FFS!!
June 28, 2025 at 5:44 AM
@edinburghairport.bsky.social What are you playing at? Delta 122 flight from Boston lands 06:30 Passengers have to wait on plane cos Customs hall does not open until 07:00 - Ridiculous get your act together FFS!!
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
www.nytimes.com
June 4, 2025 at 3:01 PM
New powerful article up in the New York Times on cancelled and delayed grants
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Looking forward to my visit to ibfg.usal-csic.es in Salamanca today. Thanks to Alfonso Fernandez Alvarez for inviting me.
May 30, 2025 at 5:07 AM
Looking forward to my visit to ibfg.usal-csic.es in Salamanca today. Thanks to Alfonso Fernandez Alvarez for inviting me.
NB: the UK - including Scotland - is an ERC partner, English speaking and has an exceptionally strong discovery research base.
Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.
Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik
#ChooseEurope
May 20, 2025 at 9:39 PM
NB: the UK - including Scotland - is an ERC partner, English speaking and has an exceptionally strong discovery research base.
Congratulations to our colleague Prof Donal O’Carroll FRS, School of Biological Sciences, University of Edinburgh, on his election as a fellow of the Royal Society of London (the UK nation academy of sciences) - very well deserved.
We are pleased to announce the 90 outstanding researchers from across the world who have been elected to the Fellowship of the Royal Society this year. The group includes trailblazers from AI and electron microscopy to global health and neuroscience. #RSFellows royalsociety.org/news/2025/05...
Exceptional scientists elected as Fellows of the Royal Society | Royal Society
Over 90 outstanding researchers from across the world have this year been elected to the Fellowship of the Royal Society, the UK’s national academy of sciences.
royalsociety.org
May 20, 2025 at 10:05 AM
Congratulations to our colleague Prof Donal O’Carroll FRS, School of Biological Sciences, University of Edinburgh, on his election as a fellow of the Royal Society of London (the UK nation academy of sciences) - very well deserved.
And now for something completely different: my nephew Arthur Allshire (1st yr PhD student @bair.berkeley.edu) and co just released his first paper: Videomimic - Visual imitation enables contextual humanoid control. He is now working on sobering up the robot! www.videomimic.net
VideoMimic
www.videomimic.net
May 20, 2025 at 8:21 AM
And now for something completely different: my nephew Arthur Allshire (1st yr PhD student @bair.berkeley.edu) and co just released his first paper: Videomimic - Visual imitation enables contextual humanoid control. He is now working on sobering up the robot! www.videomimic.net
Gov.UK now needs to be proactive in making it attractive for disaffected scientists to move to the UK. Advantages: English speaking & exceptionally strong research base. An opportunity to drive future economic growth - act now or miss out! arstechnica.com/science/2025...
Europe launches program to lure scientists away from the US
EU will spend over $500 million to recruit researchers and scientists.
arstechnica.com
May 13, 2025 at 7:15 AM
Gov.UK now needs to be proactive in making it attractive for disaffected scientists to move to the UK. Advantages: English speaking & exceptionally strong research base. An opportunity to drive future economic growth - act now or miss out! arstechnica.com/science/2025...
Pros: English speaking, strong research base. Cons: visa/health costs & broke universities. If, like EU, UK is to benefit by attracting disaffected talented scientists from other countries Gov.UK will need to make moving here attractive & affordable! Many non-OxBridge Universities can’t recruit.
"Researchers recruited to work in the UK have to fund a £1,035 annual immigration health surcharge, which must be paid in full in advance, as well as up to £1,519 in visa fees. For a family of four, the upfront costs can total almost £30,000."
“The visa fees are so exceedingly high that it makes coming here very difficult for some people. We are fishing for the best scientists in the world. They want to come and work here because we are such an effective country at science, but if we have these high costs, they can and will go elsewhere.”
May 13, 2025 at 7:03 AM
Pros: English speaking, strong research base. Cons: visa/health costs & broke universities. If, like EU, UK is to benefit by attracting disaffected talented scientists from other countries Gov.UK will need to make moving here attractive & affordable! Many non-OxBridge Universities can’t recruit.
Happy 65th to Paul Hewson (aka Bono @U2) as usual mine follows soon after yours - funny that. ‘It’s a beautiful day’ enjoy!
a man wearing sunglasses with his mouth open and the words it 's a beautiful day below him
ALT: a man wearing sunglasses with his mouth open and the words it 's a beautiful day below him
media.tenor.com
May 10, 2025 at 8:54 AM
Happy 65th to Paul Hewson (aka Bono @U2) as usual mine follows soon after yours - funny that. ‘It’s a beautiful day’ enjoy!
Looks like a fantastic AI tool for predicting protein sequences that will aggregate/form prions. Key was testing >100,000 in vivo using a neat assay in yeast/S. cerevisiae
We quantify the aggregation of >100,000 random protein sequences to train CANYA, a convolution-attention hybrid neural network to predict aggregation from sequence. With @bennibolo.bsky.social www.science.org/doi/10.1126/...
Massive experimental quantification allows interpretable deep learning of protein aggregation
xAI trained on >100,000 random peptides predicts and elucidates primary sequence determinants of aggregation.
www.science.org
May 5, 2025 at 8:29 AM
Looks like a fantastic AI tool for predicting protein sequences that will aggregate/form prions. Key was testing >100,000 in vivo using a neat assay in yeast/S. cerevisiae
Register for the excellent Epigenetics Gordon Research Conference Barcelona 10-15 Aug25. Theme: Epigenetic Variation: Mechanisms & Impact Across Systems. **FUNDING AVAILABLE to support attendance** ~15 talks to be chosen from submitted abstracts, so upload yours ASAP:
www.grc.org/epigenetics-...
www.grc.org/epigenetics-...
April 30, 2025 at 9:28 PM
Register for the excellent Epigenetics Gordon Research Conference Barcelona 10-15 Aug25. Theme: Epigenetic Variation: Mechanisms & Impact Across Systems. **FUNDING AVAILABLE to support attendance** ~15 talks to be chosen from submitted abstracts, so upload yours ASAP:
www.grc.org/epigenetics-...
www.grc.org/epigenetics-...
Congratulations to Wendy Bickmore on her election as an International Member of the US National Academy of Sciences www.nasonline.org
National Academy of Sciences
The National Academy of Sciences (NAS) is a private, nonprofit organization of the country’s leading researchers, recognizing and promoting outstanding science.
www.nasonline.org
April 30, 2025 at 9:49 AM
Congratulations to Wendy Bickmore on her election as an International Member of the US National Academy of Sciences www.nasonline.org
Congratulations to Bill Earnshaw, my colleague and lab next door, on his election as a Member of the US National Academy of Sciences www.nasonline.org
National Academy of Sciences
The National Academy of Sciences (NAS) is a private, nonprofit organization of the country’s leading researchers, recognizing and promoting outstanding science.
www.nasonline.org
April 30, 2025 at 9:48 AM
Congratulations to Bill Earnshaw, my colleague and lab next door, on his election as a Member of the US National Academy of Sciences www.nasonline.org
movie u have watched more than six times using gifs
(hard mode no star wars star trek or LOTR)
“I never had any friends later on like the ones I had when I was twelve. Jesus, does anyone?”
(hard mode no star wars star trek or LOTR)
“I never had any friends later on like the ones I had when I was twelve. Jesus, does anyone?”
a movie poster for stand by me shows a group of young men walking down train tracks
ALT: a movie poster for stand by me shows a group of young men walking down train tracks
media.tenor.com
April 26, 2025 at 2:49 PM
movie u have watched more than six times using gifs
(hard mode no star wars star trek or LOTR)
“I never had any friends later on like the ones I had when I was twelve. Jesus, does anyone?”
(hard mode no star wars star trek or LOTR)
“I never had any friends later on like the ones I had when I was twelve. Jesus, does anyone?”
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Our latest collaborative work with Keith Matthews’ lab using synthetic DNA binding proteins to explore the chromatin protein contexts of repetitive sequences in Trypanosoma brucei in now on bioRxiv - thanks to all involved! 2025.04.22.649942; doi: doi.org/10.1101/2025...
Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...
doi.org
April 24, 2025 at 12:11 PM
Our latest collaborative work with Keith Matthews’ lab using synthetic DNA binding proteins to explore the chromatin protein contexts of repetitive sequences in Trypanosoma brucei in now on bioRxiv - thanks to all involved! 2025.04.22.649942; doi: doi.org/10.1101/2025...
Almost there! 6 more points to seal it.
April 18, 2025 at 9:08 PM
Almost there! 6 more points to seal it.
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Very pleased to see @who.int publishing its very first reports on tests and treatments for #fungal #infections - and the contributions made by @bachmanntill.bsky.social, EID AMR Strategy lead.
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
@allshire-lab.bsky.social @bethmills.bsky.social
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
@allshire-lab.bsky.social @bethmills.bsky.social
Edinburgh contributes to major WHO reports on fungal infections
April 2025: The World Health Organisation has issued its first-ever reports on tests and treatments for fungal infections.
edinburgh-infectious-diseases.ed.ac.uk
April 2, 2025 at 1:37 PM
Very pleased to see @who.int publishing its very first reports on tests and treatments for #fungal #infections - and the contributions made by @bachmanntill.bsky.social, EID AMR Strategy lead.
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
@allshire-lab.bsky.social @bethmills.bsky.social
edinburgh-infectious-diseases.ed.ac.uk/news-and-eve...
@allshire-lab.bsky.social @bethmills.bsky.social
How chromatin is replicated - key to understanding epigenetic memory mechanisms underlying epimutations
🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
April 6, 2025 at 10:25 PM
How chromatin is replicated - key to understanding epigenetic memory mechanisms underlying epimutations
Register for the renowned Epigenetics Gordon Research Conference Barcelona 10-15 August 2025. A great line up of speakers on the theme: Epigenetic Variation: Mechanisms & Impact Across Systems. ~15 talks to be chosen from submitted abstracts, so upload yours ASAP:
www.grc.org/epigenetics-...
www.grc.org/epigenetics-...
www.grc.org
March 22, 2025 at 4:52 PM
Register for the renowned Epigenetics Gordon Research Conference Barcelona 10-15 August 2025. A great line up of speakers on the theme: Epigenetic Variation: Mechanisms & Impact Across Systems. ~15 talks to be chosen from submitted abstracts, so upload yours ASAP:
www.grc.org/epigenetics-...
www.grc.org/epigenetics-...
20’ until the News Agents but the world to rights - or lefts or mid-road really- in the Usher Hall, Edinburgh
March 11, 2025 at 7:16 PM
20’ until the News Agents but the world to rights - or lefts or mid-road really- in the Usher Hall, Edinburgh
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
BREAKING: Elon Musk's rocket explosion nearly hit a commercial flight.
This kind of content is being downranked on X. Please share it here. This is so dangerous.
This kind of content is being downranked on X. Please share it here. This is so dangerous.
March 7, 2025 at 4:21 AM
BREAKING: Elon Musk's rocket explosion nearly hit a commercial flight.
This kind of content is being downranked on X. Please share it here. This is so dangerous.
This kind of content is being downranked on X. Please share it here. This is so dangerous.