Alison Harrod
@alison-harrod.bsky.social
Postdoctoral Training Fellow in the Downs Lab at the Institute of Cancer Research, London
Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social
Some Friday reading...new review in Open Biology where we discuss how SWI/SNF maintains the chromatin environment around centromeres, building on recent work from ourselves and others. Lots of fun putting this together with @alison-harrod.bsky.social and @thedownslab.bsky.social!
Boundary issues: SWI/SNF shapes chromatin patterns in and around centromeres
Abstract. The SWI/SNF family of chromatin remodelling complexes, comprising BAF, PBAF and ncBAF, is known for their critical roles in regulating chromatin
royalsocietypublishing.org
December 5, 2025 at 4:57 PM
Our new review, looking into the roles of SWI/SNF in the chromatin environment around centromeres, is just out in Open Biology! @kezlane.bsky.social @thedownslab.bsky.social
Reposted by Alison Harrod
The amazing @lillianwu.bsky.social is now the amazing Dr Lillian Wu 🎉 She passed her viva with flying colours. Massive thanks to her wonderful examiners @esashilab.bsky.social and @viji-draviam.bsky.social
October 30, 2025 at 5:52 PM
The amazing @lillianwu.bsky.social is now the amazing Dr Lillian Wu 🎉 She passed her viva with flying colours. Massive thanks to her wonderful examiners @esashilab.bsky.social and @viji-draviam.bsky.social
Reposted by Alison Harrod
Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall
October 27, 2025 at 7:37 PM
Congratulations to Dr Noa Amin (times two since she was already a medical doctor but now has an amazing PhD)!!! #proudsupervisor Beautiful @icr.ac.uk award ceremony at the Guildhall
It was a pleasure to present my work at the AlterNAT meeting last week! Thank you to the organisers for a really interesting meeting, and for the opportunity to present my work. @biochemsoc.bsky.social
Congratulations 🥳 @alison-harrod.bsky.social for winning the oral communication prize at the Biochemical Society Alternative Nucleic Acid Topology meeting for her talk on SMARCA4 and G quadruplexes! 🎉👏🎉
July 18, 2025 at 9:31 AM
It was a pleasure to present my work at the AlterNAT meeting last week! Thank you to the organisers for a really interesting meeting, and for the opportunity to present my work. @biochemsoc.bsky.social
Reposted by Alison Harrod
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
July 4, 2025 at 2:09 PM
A little shout-out to the lab, who have been out in force lately presenting their work! Starting with @alison-harrod.bsky.social talking about her work with Pedro Zuazua Villar and @naghamg.bsky.social on SMARCA4 and G quadruplexes
Reposted by Alison Harrod
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ARID1A stabilises non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatin
ARID1A is a subunit of the BAF chromatin remodelling complex that is frequently mutated in cancer. It is challenging to predict how ARID1A loss impacts cancer therapy response because it participates ...
www.biorxiv.org
May 27, 2025 at 5:32 PM
New preprint from the lab on ARID1A, G quadruplexes, and repair:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alison Harrod
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
PBRM1 directs PBAF to pericentromeres and protects centromere integrity - Nature Communications
Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is frequently misregulated in cancer...
www.nature.com
March 5, 2025 at 2:44 PM
If you like chromatin remodellers and centromeres, this might be of interest. In it, we generated omics data from isogenic PBRM1 cell lines, which we hope is of use to the community, freely available (when evil forces aren't messing with the publicly funded websites 🙄) www.nature.com/articles/s41...
Reposted by Alison Harrod
Delighted to share that our paper on the role of PBAF in centromere integrity is out now in @natcomms.bsky.social! It was a long journey but it was made so much easier thanks to my co-first author/coding whiz @alison-harrod.bsky.social, the whole @thedownslab.bsky.social team, & our wonderful boss!
PBRM1 directs PBAF to pericentromeres and protects centromere integrity
Nature Communications - Centromere fragility can drive tumourigenesis, so protective mechanisms are important. Here, the authors suggest that the PBAF chromatin remodelling complex, which is...
rdcu.be
March 3, 2025 at 11:49 AM
Delighted to share that our paper on the role of PBAF in centromere integrity is out now in @natcomms.bsky.social! It was a long journey but it was made so much easier thanks to my co-first author/coding whiz @alison-harrod.bsky.social, the whole @thedownslab.bsky.social team, & our wonderful boss!
Cheers @kezlane.bsky.social to our co-first author paper on PBRM1 and the centromere being published this week in @naturecomms.bsky.social! @thedownslab.bsky.social @icr.ac.uk
February 28, 2025 at 10:21 PM
Cheers @kezlane.bsky.social to our co-first author paper on PBRM1 and the centromere being published this week in @naturecomms.bsky.social! @thedownslab.bsky.social @icr.ac.uk
Reposted by Alison Harrod
My lab is #hiring!
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
Research Fellow at University of Birmingham
Discover an exciting academic career path as a Research Fellow at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
www.jobs.ac.uk
January 31, 2025 at 10:01 AM
My lab is #hiring!
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
I am recruiting for two #Postdoc positions investigating the Alternative Lengthening of Telomeres mechanism.
www.jobs.ac.uk/job/DLO693/r...
www.jobs.ac.uk/job/DLP016/r...
#Telomere #DNAreplication #DNArepair #cancer #glioma #UKRI #MRC #universityofbirmingham #NGS
Reposted by Alison Harrod
We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10...
It's a great team and a wonderful place to work!
It's a great team and a wonderful place to work!
Scientific Officer - Epigenetics and Genome Stability in Chelsea | The Institute of Cancer Research
View details and apply for this Scientific Officer - Epigenetics and Genome Stability vacancy in Chelsea .
Salary : Commencement on the salary range is subject to comparable skills and exp...
jobs.icr.ac.uk
December 13, 2024 at 6:37 PM
We are looking for someone to join our lab as a researcher (scientific officer). Advert and information on applying is here: jobs.icr.ac.uk/vacancies/10...
It's a great team and a wonderful place to work!
It's a great team and a wonderful place to work!
Reposted by Alison Harrod
Lab retreat 2024! We had days of excellent science, food, ideas, food, games, food, discussions, food, and brainstorming.
And snacks.
And snacks.
November 30, 2024 at 5:52 PM
Lab retreat 2024! We had days of excellent science, food, ideas, food, games, food, discussions, food, and brainstorming.
And snacks.
And snacks.