Aaron Hecht, MD, PhD
@alhecht.bsky.social
Gastro physician-scientist. Studying how diet determines our risk of infections. Opinions my own.
Pinned
Aaron Hecht, MD, PhD
@alhecht.bsky.social
· Mar 27
Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection
Dissemination of organisms from the gut microbiota is a major contributor to sepsis and critical illness. Patients with cirrhosis are prone to systemic infections and are commonly prescribed the carbo...
www.biorxiv.org
I'm excited to share our new pre-print on how the drug lactulose drives evolution and systemic infection of pathobionts from the gut! Thanks to all of the incredible folks who worked on this project and our amazing collaborators!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Our lab is now open for business at Mayo Clinic in Rochester, Minnesota! We're looking for a post-doctoral fellow, interested in working at the interface of diet, microbiome and gut/liver disease. Send me a message if you want to learn more!
Life-Changing Careers at Mayo Clinic
Learn more about applying for Research Fellow - Gastroenterology and Hepatology at Mayo Clinic
jobs.mayoclinic.org
August 1, 2025 at 10:55 PM
Our lab is now open for business at Mayo Clinic in Rochester, Minnesota! We're looking for a post-doctoral fellow, interested in working at the interface of diet, microbiome and gut/liver disease. Send me a message if you want to learn more!
Reposted by Aaron Hecht, MD, PhD
🆕 Review examines immune dysfunction and infection risk in advanced #liver disease. Read the full article here: www.gastrojournal.org/article/S001...
May 30, 2025 at 4:56 PM
🆕 Review examines immune dysfunction and infection risk in advanced #liver disease. Read the full article here: www.gastrojournal.org/article/S001...
Reposted by Aaron Hecht, MD, PhD
Incredibly honored to be selected as a @bwfund.bsky.social Investigator in the Pathogenesis of Infectious Disease. Thank you to @bwfund.bsky.social for supporting our work - I am thrilled to join this amazing community! And special thank you to my AMAZING team (past & present) for getting us here!
Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease www.bwfund.org/news/announc... #bwfpath
Announcing the 2025 Investigators in the Pathogenesis of Infectious Disease - Burroughs Wellcome Fund
DURHAM, N.C. – The Burroughs Wellcome Fund proudly announces the 2025 Investigators in the Pathogenesis of Infectious Disease (PATH) award recipients. This year’s cohort represents a diverse group of…
www.bwfund.org
May 23, 2025 at 5:22 PM
Incredibly honored to be selected as a @bwfund.bsky.social Investigator in the Pathogenesis of Infectious Disease. Thank you to @bwfund.bsky.social for supporting our work - I am thrilled to join this amazing community! And special thank you to my AMAZING team (past & present) for getting us here!
Reposted by Aaron Hecht, MD, PhD
Check out this new work from the Center for Microbial Medicine(@centermicrobialmed.bsky.social) and @upenn.edu! Amanda PeBenito @rinniehewlett.bsky.social @joeyzacks.bsky.social @alhecht.bsky.social and team show that dietary fiber alters risk for C. diff infection following antibiotics.
Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection
Clostridioides difficile epidemiology is rapidly evolving, and understanding the factors that contribute to one’s risk of C. difficile infection (CDI) is urgently needed. Based on our observations in a dietary intervention study, we hypothesized that fiber modulates susceptibility to C. difficile post-antibiotic exposure and investigated this using human specimens and murine models.
secure.jbs.elsevierhealth.com
May 21, 2025 at 10:39 AM
Check out this new work from the Center for Microbial Medicine(@centermicrobialmed.bsky.social) and @upenn.edu! Amanda PeBenito @rinniehewlett.bsky.social @joeyzacks.bsky.social @alhecht.bsky.social and team show that dietary fiber alters risk for C. diff infection following antibiotics.
Reposted by Aaron Hecht, MD, PhD
Excited to share our new work in @aga-gastro.bsky.social! We show that dietary fiber alters the window of susceptibility to C. difficile following antibiotic exposure. This really fantastic study was co-led by an amazing team @rinniehewlett.bsky.social @alhecht.bsky.social and Amanda PeBenito.
Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection
Clostridioides difficile epidemiology is rapidly evolving, and understanding the factors
that contribute to one’s risk of C. difficile infection (CDI) is urgently needed.
Based on our observations in ...
www.gastrojournal.org
May 16, 2025 at 9:20 PM
Excited to share our new work in @aga-gastro.bsky.social! We show that dietary fiber alters the window of susceptibility to C. difficile following antibiotic exposure. This really fantastic study was co-led by an amazing team @rinniehewlett.bsky.social @alhecht.bsky.social and Amanda PeBenito.
Reposted by Aaron Hecht, MD, PhD
Congratulations to the @apsphysiology.bsky.social GI & Liver Section Horace W. Davenport Distinguished Award recipient, Dr. Gail Hecht! 🎉🍾 #GIsky #Gastrosky #GIresearch
April 26, 2025 at 2:44 AM
Congratulations to the @apsphysiology.bsky.social GI & Liver Section Horace W. Davenport Distinguished Award recipient, Dr. Gail Hecht! 🎉🍾 #GIsky #Gastrosky #GIresearch
Reposted by Aaron Hecht, MD, PhD
Super proud of my former lab mate and friend. It’s been amazing to witness this journey from the very beginning to the grand finale hehehe. Thrilled to be a part of it-Congratulations, Sree! ☺️ 🎉🎉🎉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Colonic goblet cell-associated antigen passages mediate physiologic and beneficial translocation of live gut bacteria in preweaning mice - Nature Microbiology
Colonic goblet cell-associated passages allow translocation of live bacteria to other organs in early life, potentially leading to beneficial impacts.
www.nature.com
April 1, 2025 at 8:06 PM
Super proud of my former lab mate and friend. It’s been amazing to witness this journey from the very beginning to the grand finale hehehe. Thrilled to be a part of it-Congratulations, Sree! ☺️ 🎉🎉🎉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aaron Hecht, MD, PhD
Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection https://www.biorxiv.org/content/10.1101/2025.03.26.645536v1
March 26, 2025 at 11:16 PM
Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection https://www.biorxiv.org/content/10.1101/2025.03.26.645536v1
I'm excited to share our new pre-print on how the drug lactulose drives evolution and systemic infection of pathobionts from the gut! Thanks to all of the incredible folks who worked on this project and our amazing collaborators!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Carbohydrate consumption drives adaptive mutations in Escherichia coli associated with increased risk for systemic infection
Dissemination of organisms from the gut microbiota is a major contributor to sepsis and critical illness. Patients with cirrhosis are prone to systemic infections and are commonly prescribed the carbo...
www.biorxiv.org
March 27, 2025 at 3:25 PM
I'm excited to share our new pre-print on how the drug lactulose drives evolution and systemic infection of pathobionts from the gut! Thanks to all of the incredible folks who worked on this project and our amazing collaborators!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...