Alexandra
@alexandrammar.bsky.social
PhD Student at MPI for Molecular Genetics 👩🏼🔬 excited about the dynamics of chromatin architecture 📿
Reposted by Alexandra
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 1:02 PM
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reposted by Alexandra
We had two great 'Night Science' workshops on the creative scientific process in Heidelberg yesterday (at EMBL and at the EMBO PhD Course). Here are the slides if you're interested in running something like this at your place! docs.google.com/presentation...
May 20, 2025 at 10:24 PM
We had two great 'Night Science' workshops on the creative scientific process in Heidelberg yesterday (at EMBL and at the EMBO PhD Course). Here are the slides if you're interested in running something like this at your place! docs.google.com/presentation...
Reposted by Alexandra
📣 Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 22, 2024 at 11:58 AM
📣 Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...