Alfred Lentzsch
@alentzsch.bsky.social
Scientist @JohnsHopkins
Ribosomes and enzymes
Ribosomes and enzymes
Check out our recent paper! Using biochemical reconstitution, computational modeling, and cellular assays, we show that the regulatory protein HYPK fine-tunes ribosome binding of the cotranslational N-acetyltransferase NatA, enabling it to acetylate ~40% of the proteome.
Online Now: HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA Online now:
HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA
Huntingtin-interacting protein K (HYPK) promotes the activity of N-terminal acetyltransferase A (NatA), which cotranslationally acetylates 40% of the eukaryotic proteome. Kinetic and in-cell measurements revealed that HYPK acts as a ribosome exchange factor for NatA, enabling its access to and acetylation of the translatome.
dlvr.it
December 11, 2025 at 3:29 PM
Check out our recent paper! Using biochemical reconstitution, computational modeling, and cellular assays, we show that the regulatory protein HYPK fine-tunes ribosome binding of the cotranslational N-acetyltransferase NatA, enabling it to acetylate ~40% of the proteome.
Reposted by Alfred Lentzsch
Reposted by Alfred Lentzsch
Online Now: Mechanism of cotranslational protein N-myristoylation in human cells Online now:
Mechanism of cotranslational protein N-myristoylation in human cells
In structure-function studies, Gamerdinger and Echeverria et al. uncover the cotranslational mechanism of N-myristoyltransferases (NMTs), essential enzymes that attach a lipid anchor to newborn proteins. They show that NMT activity is orchestrated by a key regulator at the ribosomal tunnel exit, the nascent polypeptide-associated complex (NAC).
dlvr.it
July 9, 2025 at 3:20 PM
Online Now: Mechanism of cotranslational protein N-myristoylation in human cells Online now:
Check out this review we wrote in JMB, together with Profs. Jae Ho Lee and Shu-ou Shan, on the mechanisms of cotranslational protein biogenesis!
Mechanistic insights into protein biogenesis and maturation on the ribosome
The ribosome is a major cellular machine that converts genetic information into biological function. Emerging data show that the ribosome is not only …
www.sciencedirect.com
March 4, 2025 at 4:41 PM
Check out this review we wrote in JMB, together with Profs. Jae Ho Lee and Shu-ou Shan, on the mechanisms of cotranslational protein biogenesis!