Javier Alegre-Cortés
@alegrecortes.bsky.social
Postdoc at @karalis-lab.bsky.social - @institutducerveau.bsky.social
I create computational models to build hypothesis and make predictions.
Philosophy of science aficionado
I create computational models to build hypothesis and make predictions.
Philosophy of science aficionado
Silent hills vibes at Izu peninsula
October 20, 2025 at 9:26 AM
Silent hills vibes at Izu peninsula
Here we go again
October 2, 2025 at 7:41 AM
Here we go again
Life update!🚨
I'm very happy to join @karalis-lab.bsky.social at @institutducerveau.bsky.social 🇫🇷, where I will explore how neuromodulation shapes circuit dynamics. Stay tuned!
I'm very happy to join @karalis-lab.bsky.social at @institutducerveau.bsky.social 🇫🇷, where I will explore how neuromodulation shapes circuit dynamics. Stay tuned!
April 1, 2025 at 2:36 PM
Life update!🚨
I'm very happy to join @karalis-lab.bsky.social at @institutducerveau.bsky.social 🇫🇷, where I will explore how neuromodulation shapes circuit dynamics. Stay tuned!
I'm very happy to join @karalis-lab.bsky.social at @institutducerveau.bsky.social 🇫🇷, where I will explore how neuromodulation shapes circuit dynamics. Stay tuned!
Last Sunday rice before leaving Alicante to start a new scientific adventure
March 23, 2025 at 12:42 PM
Last Sunday rice before leaving Alicante to start a new scientific adventure
When in Rome...
March 21, 2025 at 3:07 PM
When in Rome...
Oil on canvas displaying a PI proposing to their PhD student a new "small project that will take only a few weeks"
December 20, 2024 at 9:47 AM
Oil on canvas displaying a PI proposing to their PhD student a new "small project that will take only a few weeks"
A few pictures from yesterday's hike in Rigi
December 2, 2024 at 10:30 AM
A few pictures from yesterday's hike in Rigi
The Reig lab just landed on Bluesky!
Follow us if you are interested on cortico-striatal activity and its neuromodulation!
Or if you love to see in vivo whole-cell patch clamp recordings from time to time 😉
Follow us if you are interested on cortico-striatal activity and its neuromodulation!
Or if you love to see in vivo whole-cell patch clamp recordings from time to time 😉
November 28, 2024 at 7:08 PM
The Reig lab just landed on Bluesky!
Follow us if you are interested on cortico-striatal activity and its neuromodulation!
Or if you love to see in vivo whole-cell patch clamp recordings from time to time 😉
Follow us if you are interested on cortico-striatal activity and its neuromodulation!
Or if you love to see in vivo whole-cell patch clamp recordings from time to time 😉
14/n
As an example, increasing gabaergic conductance lengthened the Up state and increased the nº of peaks, without impacting the subthreshold properties of the neighbor population (color code above).
As an example, increasing gabaergic conductance lengthened the Up state and increased the nº of peaks, without impacting the subthreshold properties of the neighbor population (color code above).
November 22, 2024 at 10:43 AM
14/n
As an example, increasing gabaergic conductance lengthened the Up state and increased the nº of peaks, without impacting the subthreshold properties of the neighbor population (color code above).
As an example, increasing gabaergic conductance lengthened the Up state and increased the nº of peaks, without impacting the subthreshold properties of the neighbor population (color code above).
13/n
So, in the end, which SWA properties are the result of local features and relatively blind to the global state of the network? Changes in the E/I balance had a local impact on the length and number of peaks in the Up states (Diplets from elifesciences.org/articles/60580)
So, in the end, which SWA properties are the result of local features and relatively blind to the global state of the network? Changes in the E/I balance had a local impact on the length and number of peaks in the Up states (Diplets from elifesciences.org/articles/60580)
November 22, 2024 at 10:43 AM
13/n
So, in the end, which SWA properties are the result of local features and relatively blind to the global state of the network? Changes in the E/I balance had a local impact on the length and number of peaks in the Up states (Diplets from elifesciences.org/articles/60580)
So, in the end, which SWA properties are the result of local features and relatively blind to the global state of the network? Changes in the E/I balance had a local impact on the length and number of peaks in the Up states (Diplets from elifesciences.org/articles/60580)
12/n
This allowed us to created a middle ground for discussion between a physiological perspective and a dynamical system viewpoint. We could explore the prediction of mean-field theories and connect them to mechanistically precise substrates.
This allowed us to created a middle ground for discussion between a physiological perspective and a dynamical system viewpoint. We could explore the prediction of mean-field theories and connect them to mechanistically precise substrates.
November 22, 2024 at 10:43 AM
12/n
This allowed us to created a middle ground for discussion between a physiological perspective and a dynamical system viewpoint. We could explore the prediction of mean-field theories and connect them to mechanistically precise substrates.
This allowed us to created a middle ground for discussion between a physiological perspective and a dynamical system viewpoint. We could explore the prediction of mean-field theories and connect them to mechanistically precise substrates.
10/n
We sequentially manipulated the glutamatergic and gabaergic currents in our model, as well as the outward rectification currents. We characterized how they impacted the SWA, the influence of long-range connections, and if the changes remained local.
We sequentially manipulated the glutamatergic and gabaergic currents in our model, as well as the outward rectification currents. We characterized how they impacted the SWA, the influence of long-range connections, and if the changes remained local.
November 22, 2024 at 10:43 AM
10/n
We sequentially manipulated the glutamatergic and gabaergic currents in our model, as well as the outward rectification currents. We characterized how they impacted the SWA, the influence of long-range connections, and if the changes remained local.
We sequentially manipulated the glutamatergic and gabaergic currents in our model, as well as the outward rectification currents. We characterized how they impacted the SWA, the influence of long-range connections, and if the changes remained local.
8/n
We performed in vivo experiments, locally increasing the frequency of the SWA in the caudal cortical pole and showed how this reverses the direction of the travelling waves and increased the frequency of Up states along the cortex.
We performed in vivo experiments, locally increasing the frequency of the SWA in the caudal cortical pole and showed how this reverses the direction of the travelling waves and increased the frequency of Up states along the cortex.
November 22, 2024 at 10:43 AM
8/n
We performed in vivo experiments, locally increasing the frequency of the SWA in the caudal cortical pole and showed how this reverses the direction of the travelling waves and increased the frequency of Up states along the cortex.
We performed in vivo experiments, locally increasing the frequency of the SWA in the caudal cortical pole and showed how this reverses the direction of the travelling waves and increased the frequency of Up states along the cortex.
6/n
We show how differences in excitability became difficult to infer when populations are connected, as the most excitable one will impose its own rhythm, impacting global firing dynamics and subthreshold parameters.
We show how differences in excitability became difficult to infer when populations are connected, as the most excitable one will impose its own rhythm, impacting global firing dynamics and subthreshold parameters.
November 22, 2024 at 10:43 AM
6/n
We show how differences in excitability became difficult to infer when populations are connected, as the most excitable one will impose its own rhythm, impacting global firing dynamics and subthreshold parameters.
We show how differences in excitability became difficult to infer when populations are connected, as the most excitable one will impose its own rhythm, impacting global firing dynamics and subthreshold parameters.
5/n
To do so we built conductance-based models of neuronal populations following the work of Albert Compte journals.physiology.org/doi/full/10....), and extended it to multiple connected populations with heterogeneous levels of excitability.
To do so we built conductance-based models of neuronal populations following the work of Albert Compte journals.physiology.org/doi/full/10....), and extended it to multiple connected populations with heterogeneous levels of excitability.
November 22, 2024 at 10:43 AM
5/n
To do so we built conductance-based models of neuronal populations following the work of Albert Compte journals.physiology.org/doi/full/10....), and extended it to multiple connected populations with heterogeneous levels of excitability.
To do so we built conductance-based models of neuronal populations following the work of Albert Compte journals.physiology.org/doi/full/10....), and extended it to multiple connected populations with heterogeneous levels of excitability.
I'll be presenting my work at the #FENS2024 Basal Ganglia Satellite Meeting! I'm looking forward to sharing and discussing my work on modelling cortico-striatal Slow Waves. If you will be around, come and say hi!
May 21, 2024 at 12:52 PM
I'll be presenting my work at the #FENS2024 Basal Ganglia Satellite Meeting! I'm looking forward to sharing and discussing my work on modelling cortico-striatal Slow Waves. If you will be around, come and say hi!
A few photos from today's walk.
December 14, 2023 at 7:41 AM
A few photos from today's walk.
A few pictures from our first day in Japan, visiting Osaka
October 6, 2023 at 10:38 PM
A few pictures from our first day in Japan, visiting Osaka
Pro tip: In order to do a successfull rehearsal, it is convenient to include a realistic simulation of a coffee break
September 29, 2023 at 10:00 AM
Pro tip: In order to do a successfull rehearsal, it is convenient to include a realistic simulation of a coffee break
Take a look at this cool app!
I tried it with my PubMed profile and this is the result
I tried it with my PubMed profile and this is the result
September 25, 2023 at 12:20 PM
Take a look at this cool app!
I tried it with my PubMed profile and this is the result
I tried it with my PubMed profile and this is the result