AldrinAU
@aldrinau.bsky.social
Thoracic medicine & asthma physician. Loves family, 🍫,🍦,🍣, ☕️, and ChelseaFC (supporter since 95’). Views are my own.
‘After 52 weeks of open-label tezepelumab treatment, nearly 90% of patients with OCS-dependent severe, uncontrolled asthma had a maintenance OCS dose of 5 mg per day or less and more than 50% completely discontinued OCS, while maintaining asthma control.’ #Wayfinder
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Oral corticosteroid reduction and discontinuation in adults with corticosteroid-dependent, severe, uncontrolled asthma treated with tezepelumab (WAYFINDER): a multicentre, single-arm, phase 3b trial
After 52 weeks of open-label tezepelumab treatment, nearly 90% of patients with OCS-dependent
severe, uncontrolled asthma had a maintenance OCS dose of 5 mg per day or less and
more than 50% completel...
www.thelancet.com
November 27, 2025 at 7:07 PM
‘After 52 weeks of open-label tezepelumab treatment, nearly 90% of patients with OCS-dependent severe, uncontrolled asthma had a maintenance OCS dose of 5 mg per day or less and more than 50% completely discontinued OCS, while maintaining asthma control.’ #Wayfinder
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Reposted by AldrinAU
Historic towns elbow-to-elbow with travelers. Beaches where you can’t see the sand through the multitude of towels, chairs and umbrellas. Tourists arrested for drunk and disorderly conduct.
https://cnn.it/4oRauAI
https://cnn.it/4oRauAI
November 1, 2025 at 1:00 PM
Historic towns elbow-to-elbow with travelers. Beaches where you can’t see the sand through the multitude of towels, chairs and umbrellas. Tourists arrested for drunk and disorderly conduct.
https://cnn.it/4oRauAI
https://cnn.it/4oRauAI
Happy Father’s Day to all fathers out there. Be good. Be happy. Be thankful. Be safe.
June 15, 2025 at 12:20 PM
Happy Father’s Day to all fathers out there. Be good. Be happy. Be thankful. Be safe.
Don’t your just love freshly made bread🥰!
May 25, 2025 at 1:00 PM
Don’t your just love freshly made bread🥰!
Tackling modifiable risk factors such as obesity could make a noticeable dent in the expected rise in asthma burden over the next 25 years. The GBD 2021 estimated that global cases of the disease will rise 5.5% from 260M in 2021 to 275M by 2050. www.thelancet.com/journals/lan...
Global, regional, and national burden of asthma and atopic dermatitis, 1990–2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
Although the increases in the total number of asthma and atopic dermatitis cases will
probably continue until 2050, age-standardised prevalence rates are expected to remain
stable. A considerable port...
www.thelancet.com
April 9, 2025 at 9:22 AM
Tackling modifiable risk factors such as obesity could make a noticeable dent in the expected rise in asthma burden over the next 25 years. The GBD 2021 estimated that global cases of the disease will rise 5.5% from 260M in 2021 to 275M by 2050. www.thelancet.com/journals/lan...
‘Great Ormond Street said 22 children in 39 cases looked at so far had come to some degree of harm, and that it is taking the concerns “incredibly seriously”.The 721 patients were treated by Yaser Jabbar, a consultant orthopaedic surgeon…’
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
Great Ormond Street reviews 700 children treated by ex-surgeon - BBC News
The patients were treated by Yaser Jabbar, a consultant orthopaedic surgeon who worked at the hospital’s lower limb reconstruction service.
www.bbc.co.uk
March 24, 2025 at 7:21 PM
‘Great Ormond Street said 22 children in 39 cases looked at so far had come to some degree of harm, and that it is taking the concerns “incredibly seriously”.The 721 patients were treated by Yaser Jabbar, a consultant orthopaedic surgeon…’
www.bbc.co.uk/news/article...
www.bbc.co.uk/news/article...
The Tokyo to Osaka line — the route that launched the concept on the world and crystallised Japan’s sense of its postwar self — opened in 1964, just ahead of the equally nation-defining Olympic Games in Tokyo that same year. #shinkansen #Japan
www.ft.com/content/46bc... via @ft
www.ft.com/content/46bc... via @ft
Many happy returns: 60 years of the shinkansen
Six decades after the first bullet train left Tokyo Station, Leo Lewis celebrates an icon of speed, style and national identity
www.ft.com
March 23, 2025 at 3:31 PM
The Tokyo to Osaka line — the route that launched the concept on the world and crystallised Japan’s sense of its postwar self — opened in 1964, just ahead of the equally nation-defining Olympic Games in Tokyo that same year. #shinkansen #Japan
www.ft.com/content/46bc... via @ft
www.ft.com/content/46bc... via @ft
Reposted by AldrinAU
It's 5 yrs today since lockdown started in England, but "We must never have lockdown again" is the wrong lesson.
Lockdowns are terrible but so are deadly pandemics.
Our choices 5 years ago were limited - we can & must do better in the future.
Do read my post.
open.substack.com/pub/christin...
Lockdowns are terrible but so are deadly pandemics.
Our choices 5 years ago were limited - we can & must do better in the future.
Do read my post.
open.substack.com/pub/christin...
We are learning the wrong lessons from lockdown
And unless we learn the right ones, we risk making the same mistakes in a new pandemic
open.substack.com
March 23, 2025 at 1:41 PM
It's 5 yrs today since lockdown started in England, but "We must never have lockdown again" is the wrong lesson.
Lockdowns are terrible but so are deadly pandemics.
Our choices 5 years ago were limited - we can & must do better in the future.
Do read my post.
open.substack.com/pub/christin...
Lockdowns are terrible but so are deadly pandemics.
Our choices 5 years ago were limited - we can & must do better in the future.
Do read my post.
open.substack.com/pub/christin...
Millions of electric cars are coming. What happens to all the dead batteries? | Science | AAAS www.science.org/content/arti...
Millions of electric cars are coming. What happens to all the dead batteries?
Researchers urgently seek better ways to reuse spent cells
www.science.org
February 23, 2025 at 4:37 PM
Millions of electric cars are coming. What happens to all the dead batteries? | Science | AAAS www.science.org/content/arti...
‘Smoking is still the leading cause of premature illness and death in the UK and is responsible for half the difference in healthy life expectancy between the country’s richest and poorest people.’ #smokingkills
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Smoking’s pop culture revival is an unwelcome throwback for public health
The 1990s were characterised by a rise in teenage smoking rates. Nostalgia for that decade shouldn’t see us undo progress against this public health threat, writes Caroline Cerny
The 1990s are firml...
www.bmj.com
January 12, 2025 at 9:19 PM
‘Smoking is still the leading cause of premature illness and death in the UK and is responsible for half the difference in healthy life expectancy between the country’s richest and poorest people.’ #smokingkills
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Looking forward to the next few days when the temperature will start rising and hopefully all the snow will finally melt here.
January 12, 2025 at 12:09 PM
Looking forward to the next few days when the temperature will start rising and hopefully all the snow will finally melt here.
We noticed earlier the snow (that has yet to melt in our garden over the last one week) has developed into snow crystals or frost crystals. These intricate ice formations apparently occur when water vapor freezes directly into ice, often creating delicate, crystalline patterns.
January 11, 2025 at 7:58 PM
We noticed earlier the snow (that has yet to melt in our garden over the last one week) has developed into snow crystals or frost crystals. These intricate ice formations apparently occur when water vapor freezes directly into ice, often creating delicate, crystalline patterns.
“Despite the best efforts of NHS staff, cancer patients are waiting too long for vital tests & treatment. Cancer services have lacked the resources they need for yea, and this report highlights the real-world impact this has on people affected by cancer.”
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Hiring freeze at dozens of NHS cancer and diagnostic units despite rising referrals
Royal College of Radiologists calls move ‘shortsighted’ and says it puts Labour’s waiting times plan at risk
www.theguardian.com
January 10, 2025 at 1:38 PM
“Despite the best efforts of NHS staff, cancer patients are waiting too long for vital tests & treatment. Cancer services have lacked the resources they need for yea, and this report highlights the real-world impact this has on people affected by cancer.”
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
It’s super cold out there tonight 🥶🥶🥶-7°C
January 8, 2025 at 10:44 PM
It’s super cold out there tonight 🥶🥶🥶-7°C
Why do we need to exclude atypical Mycobacterium (NTM) before starting prophylactic Azithromycin?
Because in doing so in a person who already has an active, undiagnosed MAC infection can lead to development of resistance & inadequate treatment.
(Images source- BTS guidance)
Because in doing so in a person who already has an active, undiagnosed MAC infection can lead to development of resistance & inadequate treatment.
(Images source- BTS guidance)
January 2, 2025 at 11:17 AM
Why do we need to exclude atypical Mycobacterium (NTM) before starting prophylactic Azithromycin?
Because in doing so in a person who already has an active, undiagnosed MAC infection can lead to development of resistance & inadequate treatment.
(Images source- BTS guidance)
Because in doing so in a person who already has an active, undiagnosed MAC infection can lead to development of resistance & inadequate treatment.
(Images source- BTS guidance)
Happy New Year 2025!
May the new year brings us good health, happiness, growing wealth & especially peace🕊️. May you and your loved ones stay safe and celebrate the joy of togetherness throughout the year.
May the new year brings us good health, happiness, growing wealth & especially peace🕊️. May you and your loved ones stay safe and celebrate the joy of togetherness throughout the year.
December 31, 2024 at 3:01 PM
Happy New Year 2025!
May the new year brings us good health, happiness, growing wealth & especially peace🕊️. May you and your loved ones stay safe and celebrate the joy of togetherness throughout the year.
May the new year brings us good health, happiness, growing wealth & especially peace🕊️. May you and your loved ones stay safe and celebrate the joy of togetherness throughout the year.
‘Daily use of moderate-high dose inhaled corticosteroids was significantly associated with increased risk of pneumonia, major (adverse) cardiovascular events, and pulmonary embolism; although the mechanism for this observation is largely unknown.’
www.atsjournals.org/doi/full/10.... #asthma
www.atsjournals.org/doi/full/10.... #asthma
December 30, 2024 at 8:09 PM
‘Daily use of moderate-high dose inhaled corticosteroids was significantly associated with increased risk of pneumonia, major (adverse) cardiovascular events, and pulmonary embolism; although the mechanism for this observation is largely unknown.’
www.atsjournals.org/doi/full/10.... #asthma
www.atsjournals.org/doi/full/10.... #asthma
Reposted by AldrinAU
Between morning ward round & afternoon board round, I uploaded this preprint (if working Xmas week, might as well make the most of it)
“Cigarette smoke induces PPP1R15A via oxidative stress to modulate inflammatory cytokine production by bronchial epithelial cells”
www.biorxiv.org/content/10.1...
“Cigarette smoke induces PPP1R15A via oxidative stress to modulate inflammatory cytokine production by bronchial epithelial cells”
www.biorxiv.org/content/10.1...
Cigarette smoke induces PPP1R15A via oxidative stress to modulate inflammatory cytokine production by bronchial epithelial cells
Cigarette smoke is the principal cause of chronic obstructive pulmonary disease (COPD) in western societies. It induces pulmonary inflammation and activates multiple stress signaling pathways in bronc...
www.biorxiv.org
December 24, 2024 at 9:39 PM
Between morning ward round & afternoon board round, I uploaded this preprint (if working Xmas week, might as well make the most of it)
“Cigarette smoke induces PPP1R15A via oxidative stress to modulate inflammatory cytokine production by bronchial epithelial cells”
www.biorxiv.org/content/10.1...
“Cigarette smoke induces PPP1R15A via oxidative stress to modulate inflammatory cytokine production by bronchial epithelial cells”
www.biorxiv.org/content/10.1...
Sleep is an essential part of overall health, and getting enough restful sleep on a regular basis offers a plethora of benefits. Quality sleep helps boost energy levels and immune function, and supports cognitive processes like memory consolidation.
www.sleepfoundation.org/how-sleep-wo...
www.sleepfoundation.org/how-sleep-wo...
Sleep Debt: The Hidden Cost of Insufficient Rest
Sleep debt grows when lost sleep accumulates over time. Learn about the effects of sleep debt and tips for catching up on sleep.
www.sleepfoundation.org
December 25, 2024 at 8:11 PM
Sleep is an essential part of overall health, and getting enough restful sleep on a regular basis offers a plethora of benefits. Quality sleep helps boost energy levels and immune function, and supports cognitive processes like memory consolidation.
www.sleepfoundation.org/how-sleep-wo...
www.sleepfoundation.org/how-sleep-wo...
‘Reclaiming dying and grieving as social processes requires demedicalisation to counter the pursuit of futile interventions at the end of life and to normalise conversations about dying.’ @bmj.com
www.bmj.com/content/387/...
www.bmj.com/content/387/...
Death, love, and taxes: tales of resilience and humanity
Credit: Rowena Sheehan
Far too many people dying and grieving remain undersupported and feared. Dying is “as natural and inevitable a transition as birth,” says Lucy Selman, an expert in dying and gr...
www.bmj.com
December 23, 2024 at 8:03 PM
‘Reclaiming dying and grieving as social processes requires demedicalisation to counter the pursuit of futile interventions at the end of life and to normalise conversations about dying.’ @bmj.com
www.bmj.com/content/387/...
www.bmj.com/content/387/...
‘More widely, unrealistic expectations of medicine and pressure from families lead to requests for life prolonging treatments that might not be in the patient’s best interests.’ @bmj.com
www.bmj.com/content/387/...
www.bmj.com/content/387/...
Demedicalising dying: medicine must accept death as a natural part of life
Over the course of the 19th century, across North America and Europe, death slowly migrated from the home to the hospital and came to be viewed as a medical event, and no longer primarily a religious ...
www.bmj.com
December 23, 2024 at 8:00 PM
‘More widely, unrealistic expectations of medicine and pressure from families lead to requests for life prolonging treatments that might not be in the patient’s best interests.’ @bmj.com
www.bmj.com/content/387/...
www.bmj.com/content/387/...
Reposted by AldrinAU
EPAP (or: PEEP):
EPAP traditionally is set at low values (~ 5 cmH2O) in COPD patients. However, higher EPAP may be needed if the patient is obese and/or there is need to correct upper airway obstruction
EPAP can also help to:
i) "match" intrinsic PEEP, reducing triggering effort & asynchrony, &
EPAP traditionally is set at low values (~ 5 cmH2O) in COPD patients. However, higher EPAP may be needed if the patient is obese and/or there is need to correct upper airway obstruction
EPAP can also help to:
i) "match" intrinsic PEEP, reducing triggering effort & asynchrony, &
December 15, 2024 at 4:07 PM
EPAP (or: PEEP):
EPAP traditionally is set at low values (~ 5 cmH2O) in COPD patients. However, higher EPAP may be needed if the patient is obese and/or there is need to correct upper airway obstruction
EPAP can also help to:
i) "match" intrinsic PEEP, reducing triggering effort & asynchrony, &
EPAP traditionally is set at low values (~ 5 cmH2O) in COPD patients. However, higher EPAP may be needed if the patient is obese and/or there is need to correct upper airway obstruction
EPAP can also help to:
i) "match" intrinsic PEEP, reducing triggering effort & asynchrony, &
Reposted by AldrinAU
the NIV settings usually boil down to: inspiratory/expiratory pressure (IPAP/EPAP) and FiO2. We have to admit that not every COPD patient will do well with “10 over 5” *. So what else should we pay attention to?
December 15, 2024 at 4:07 PM
the NIV settings usually boil down to: inspiratory/expiratory pressure (IPAP/EPAP) and FiO2. We have to admit that not every COPD patient will do well with “10 over 5” *. So what else should we pay attention to?
ICU - Non-Invasive Ventilation (NIV) Secrets:
Did you ever admit to the ICU a patient with COPD exacerbation who came from the ED on NIV? Or who went home on NIV? If you are a pulmonologist, you can skip this post but, for the rest of us from different specialties (I am Internal Medicine),
Did you ever admit to the ICU a patient with COPD exacerbation who came from the ED on NIV? Or who went home on NIV? If you are a pulmonologist, you can skip this post but, for the rest of us from different specialties (I am Internal Medicine),
December 22, 2024 at 9:09 PM