Ahmed Arafa NP
ahmedarafaphd.bsky.social
Ahmed Arafa NP
@ahmedarafaphd.bsky.social
Reposted by Ahmed Arafa NP
Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology
A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale.

Single-gene-per-cell delivery coupled to an effective transcriptional selection system

www.biorxiv.org/content/10.1...
August 7, 2025 at 10:37 PM
Reposted by Ahmed Arafa NP
Nachschattengewächse als Basis für Arzneimittel: Forschungsteams der #LUH und der @unibonn.bsky.social‬ entschlüsseln Gensequenz zur Bildung von Steroiden. @dfg.de‬ fördert das Projekt mit rund 511.00 Euro. http://go.lu-h.de/aNhrb
July 14, 2025 at 12:01 PM
Reposted by Ahmed Arafa NP
Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.comrdcu.be/evHOF
Fantastic team effort with the Pucker group @bpucker.bsky.social@puckerlab.bsky.social‬ at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de
Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis
Nature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....
rdcu.be
July 10, 2025 at 5:50 PM
Reposted by Ahmed Arafa NP
Started as a very successful master thesis, now published in JACS. Screening sequence similarity networks turned out to be a great way to discover oxidosqualene cyclases with unusual activity from more than thousand plant transcriptome sequence datasets.

pubs.acs.org/doi/10.1021/...
Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants
Triterpenoids and steroids are structurally complex polycyclic natural products with potent biological functions, for example, as hormones. In all eukaryotes, the carbon skeletons of these compounds a...
pubs.acs.org
March 18, 2025 at 10:15 AM