Anders Granholm
@agranholm.bsky.social
MD, PhD, assistant professor, Intensive Care, Rigshospitalet and Section of Biostatistics, Dept. of Public Health, University of Copenhagen. Clinical trials (incl. adaptive+platform), evidence-based medicine, methodology, Bayes. www.incept.dk
Reposted by Anders Granholm
At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120
#MethodologyMonday #120
June 16, 2025 at 5:56 AM
At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9
#MethodologyMonday #120
#MethodologyMonday #120
Interested in adaptive platform trials?
INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents
@andersperner.bsky.social
INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents
@andersperner.bsky.social
March 21, 2025 at 2:55 PM
Interested in adaptive platform trials?
INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents
@andersperner.bsky.social
INCEPT (www.incept.dk) recently got approved along with the first domain, and we expect to start inclusion soon. A protocol/design paper is available at doi.org/10.1111/aas.... along with the full protocol docs at incept.dk/documents
@andersperner.bsky.social
Reposted by Anders Granholm
This past month has seen the publication of a couple of new helpful papers providing further insights into the thorny issue of #MultipleTesting in trials 1/7
#MethodologyMonday #112
#MethodologyMonday #112
February 24, 2025 at 7:47 AM
This past month has seen the publication of a couple of new helpful papers providing further insights into the thorny issue of #MultipleTesting in trials 1/7
#MethodologyMonday #112
#MethodologyMonday #112
Reposted by Anders Granholm
Good news for ICUs and patients
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients.
incept.dk
February 23, 2025 at 12:34 PM
Good news for ICUs and patients
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
The Intensive Care Platform Trial - INCEPT - was approved by the regulators
INCEPT is a very broad domain based, adaptive platform trial assessing everyday interventions in ICUs
1. enrolled in first domain (albumin use vs no use in shock) in april 2025
incept.dk
Reposted by Anders Granholm
An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8
#MethodologyMonday #109
#MethodologyMonday #109
January 27, 2025 at 7:32 AM
An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8
#MethodologyMonday #109
#MethodologyMonday #109
Reposted by Anders Granholm
Interested in design and evaluation of advanced adaptive trial designs?
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
Designing and evaluating advanced adaptive randomised clinical trials: a practical guide
Background
Advanced adaptive randomised clinical trials are increasingly used. Compared to their conventional counterparts, their flexibility may make them more efficient, increase the probability o...
doi.org
January 16, 2025 at 9:44 AM
Interested in design and evaluation of advanced adaptive trial designs?
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
Interested in design and evaluation of advanced adaptive trial designs?
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
Designing and evaluating advanced adaptive randomised clinical trials: a practical guide
Background
Advanced adaptive randomised clinical trials are increasingly used. Compared to their conventional counterparts, their flexibility may make them more efficient, increase the probability o...
doi.org
January 16, 2025 at 9:44 AM
Interested in design and evaluation of advanced adaptive trial designs?
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
See our new preprint: doi.org/10.48550/arX...
Here we summarise key methodological considerations and how to specify and evaluate them using simulations via our 'adaptr' #Rstats package (inceptdk.github.io/adaptr/)
1/..
Reposted by Anders Granholm
A Core Outcome Set for Adult General ICU Patients should include survival, free of life support, free of delirium, out of hospital, health-related quality of life, and cognitive function.
Excellent international Delphi study from Denmark
journals.lww.com/ccmjournal/f...
Excellent international Delphi study from Denmark
journals.lww.com/ccmjournal/f...
January 7, 2025 at 8:24 AM
A Core Outcome Set for Adult General ICU Patients should include survival, free of life support, free of delirium, out of hospital, health-related quality of life, and cognitive function.
Excellent international Delphi study from Denmark
journals.lww.com/ccmjournal/f...
Excellent international Delphi study from Denmark
journals.lww.com/ccmjournal/f...
Reposted by Anders Granholm
A core outcome set for general ICU patients aimed for clinical trials - developed with many stakeholder and internationally validated
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
A Core Outcome Set for Adult General ICU Patients : Critical Care Medicine
nts exist, for example, respiratory failure, delirium, and COVID-19, but not for ICU patients in general. Accordingly, we aimed to develop a core outcome set for adult general ICU patients.
Design:
...
journals.lww.com
January 8, 2025 at 8:58 PM
A core outcome set for general ICU patients aimed for clinical trials - developed with many stakeholder and internationally validated
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
Amazing work by #INCEPT trial team led by @maj-brit.bsky.social with contribution from a large group of international colleagues
journals.lww.com/ccmjournal/a...
Reposted by Anders Granholm
In clinical research, you will often receive feedback on study design, stats, and/or data analysis from an editor or reviewer that is simply wrong. Here is a list of common "statistical myths" and references you can use to push back.
discourse.datamethods.org/t/reference-...
discourse.datamethods.org/t/reference-...
Reference Collection to push back against "Common Statistical Myths"
Note: This topic is a wiki, meaning that this main body of the topic can be edited by others. Use the Reply button only to post questions or comments about material contained in the body, or to sugge...
discourse.datamethods.org
November 12, 2024 at 6:19 AM
In clinical research, you will often receive feedback on study design, stats, and/or data analysis from an editor or reviewer that is simply wrong. Here is a list of common "statistical myths" and references you can use to push back.
discourse.datamethods.org/t/reference-...
discourse.datamethods.org/t/reference-...
Reposted by Anders Granholm
This is a list of statistical myths and misconceptions that I keep coming back to. So many common avoidable mistakes. Should be read by all clinician researchers and all who want to critically read studies! #cardiosky #emimcc #stats
In clinical research, you will often receive feedback on study design, stats, and/or data analysis from an editor or reviewer that is simply wrong. Here is a list of common "statistical myths" and references you can use to push back.
discourse.datamethods.org/t/reference-...
discourse.datamethods.org/t/reference-...
Reference Collection to push back against "Common Statistical Myths"
Note: This topic is a wiki, meaning that this main body of the topic can be edited by others. Use the Reply button only to post questions or comments about material contained in the body, or to sugge...
discourse.datamethods.org
November 12, 2024 at 9:32 AM
This is a list of statistical myths and misconceptions that I keep coming back to. So many common avoidable mistakes. Should be read by all clinician researchers and all who want to critically read studies! #cardiosky #emimcc #stats