@adkelly1.bsky.social
Medicine resident at Medical College of Wisconsin. Future Nephrologist. ❤️ Medicine
Is the sigmoid concentration curve really that big of a difference from the dose response curve? The linear curve certainly would be…
November 10, 2025 at 1:23 PM
Is the sigmoid concentration curve really that big of a difference from the dose response curve? The linear curve certainly would be…
How?? Those are crazy HR’s
November 7, 2025 at 5:39 PM
How?? Those are crazy HR’s
Reposted
I mean. What? Do we believe this? Nothing works in dialysis except...fish oil?
November 7, 2025 at 5:00 PM
I mean. What? Do we believe this? Nothing works in dialysis except...fish oil?
I don’t know of any general history on the development of lab values but there’s literature in hematology on refining ferritin and anemia “normal” values… here’s a few studies if interested:
pubmed.ncbi.nlm.nih.gov/33106588/
pubmed.ncbi.nlm.nih.gov/31074518/
pubmed.ncbi.nlm.nih.gov/1487761/
pubmed.ncbi.nlm.nih.gov/33106588/
pubmed.ncbi.nlm.nih.gov/31074518/
pubmed.ncbi.nlm.nih.gov/1487761/
Clinical thresholds for diagnosing iron deficiency: comparison of functional assessment of serum ferritin to population based centiles - PubMed
Low serum ferritin is diagnostic of iron deficiency, yet its published lower cut-off values are highly variable, particularly for pediatric populations. Lower cut-off values are commonly reported as 2...
pubmed.ncbi.nlm.nih.gov
October 16, 2025 at 1:54 AM
I don’t know of any general history on the development of lab values but there’s literature in hematology on refining ferritin and anemia “normal” values… here’s a few studies if interested:
pubmed.ncbi.nlm.nih.gov/33106588/
pubmed.ncbi.nlm.nih.gov/31074518/
pubmed.ncbi.nlm.nih.gov/1487761/
pubmed.ncbi.nlm.nih.gov/33106588/
pubmed.ncbi.nlm.nih.gov/31074518/
pubmed.ncbi.nlm.nih.gov/1487761/
SABA prn instead of SMART therapy for asthma?
September 26, 2025 at 2:39 PM
SABA prn instead of SMART therapy for asthma?
Great negative predictor if normal
September 22, 2025 at 8:08 PM
Great negative predictor if normal
Should we take into account renin level when selecting an agent? (For non-PA).
If renin is low, would suggest ACE/ARB would be less efficacious, right? If high, RAASi more useful? Opposite true with diuretics? #nephjc
If renin is low, would suggest ACE/ARB would be less efficacious, right? If high, RAASi more useful? Opposite true with diuretics? #nephjc
September 17, 2025 at 2:14 AM
Should we take into account renin level when selecting an agent? (For non-PA).
If renin is low, would suggest ACE/ARB would be less efficacious, right? If high, RAASi more useful? Opposite true with diuretics? #nephjc
If renin is low, would suggest ACE/ARB would be less efficacious, right? If high, RAASi more useful? Opposite true with diuretics? #nephjc
Would anyone be willing to share a pdf? No institutional access ☹️
August 21, 2025 at 8:13 PM
Would anyone be willing to share a pdf? No institutional access ☹️
Would you have given an anti-arrhythmic in that scenario or just lowered the K? If so, what would your ideal anti-arrhythmic been?
July 27, 2025 at 4:14 AM
Would you have given an anti-arrhythmic in that scenario or just lowered the K? If so, what would your ideal anti-arrhythmic been?
Everything is relative. Everything is subjective. Nothing in medicine is independent of interpretation
July 24, 2025 at 4:17 PM
Everything is relative. Everything is subjective. Nothing in medicine is independent of interpretation
Why 1st HF hospitalization?
July 23, 2025 at 3:59 PM
Why 1st HF hospitalization?
Wonderful study! Thanks for sharing.
I assume the absolute risk would be higher in a population with more cardiometabolic risk factors -> higher MACE incidence over time? This is a remarkably healthy cohort compared to the US patient population.
I assume the absolute risk would be higher in a population with more cardiometabolic risk factors -> higher MACE incidence over time? This is a remarkably healthy cohort compared to the US patient population.
July 12, 2025 at 3:45 PM
Wonderful study! Thanks for sharing.
I assume the absolute risk would be higher in a population with more cardiometabolic risk factors -> higher MACE incidence over time? This is a remarkably healthy cohort compared to the US patient population.
I assume the absolute risk would be higher in a population with more cardiometabolic risk factors -> higher MACE incidence over time? This is a remarkably healthy cohort compared to the US patient population.
Is there any validated study that correlates X% decrease in UACR with Y% change in eGFR? Or any hard endpoints like RRT initiation, etc?
July 9, 2025 at 3:30 AM
Is there any validated study that correlates X% decrease in UACR with Y% change in eGFR? Or any hard endpoints like RRT initiation, etc?
Emphasizes the need to make these drugs accessible
July 9, 2025 at 3:17 AM
Emphasizes the need to make these drugs accessible
Why such few women?
July 9, 2025 at 3:07 AM
Why such few women?
You’re right BP meds not addressing underlying cause, but maybe no difference in outcomes due to the medications used or population?
Have this study in mind: BP reduction for ns-MRA/RASi in nocturnal HTN in pts uncontrolled HTN (no assessment hard outcomes ☹️).
pubmed.ncbi.nlm.nih.gov/40178088/
Have this study in mind: BP reduction for ns-MRA/RASi in nocturnal HTN in pts uncontrolled HTN (no assessment hard outcomes ☹️).
pubmed.ncbi.nlm.nih.gov/40178088/
Efficacy of Esaxerenone Plus a Renin-Angiotensin System Inhibitor or Calcium Channel Blocker for Nocturnal Hypertension: A Post Hoc Analysis - PubMed
Esaxerenone when used in combination with a CCB or RASi, but especially when used in combination with a RASi, may be a useful treatment option for patients with uncontrolled hypertension to control no...
pubmed.ncbi.nlm.nih.gov
July 2, 2025 at 3:05 PM
You’re right BP meds not addressing underlying cause, but maybe no difference in outcomes due to the medications used or population?
Have this study in mind: BP reduction for ns-MRA/RASi in nocturnal HTN in pts uncontrolled HTN (no assessment hard outcomes ☹️).
pubmed.ncbi.nlm.nih.gov/40178088/
Have this study in mind: BP reduction for ns-MRA/RASi in nocturnal HTN in pts uncontrolled HTN (no assessment hard outcomes ☹️).
pubmed.ncbi.nlm.nih.gov/40178088/
Has pill measuring as a compliance metric been used in other studies? Is this more common in pediatric trials?
June 11, 2025 at 2:14 AM
Has pill measuring as a compliance metric been used in other studies? Is this more common in pediatric trials?
What a great study. Thanks for sharing
June 9, 2025 at 1:54 AM
What a great study. Thanks for sharing
Able to make a downloaded pdf link available? No institutional access ☹️
May 31, 2025 at 4:53 PM
Able to make a downloaded pdf link available? No institutional access ☹️