Adélie
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adelielannoy.bsky.social
Adélie
@adelielannoy.bsky.social
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PhD student working on Brucella abortus envelope in @namurxa.bsky.social
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Reposted by Adélie
embojournal.org
Xavier DeBolle @namurxa.bsky.social and collaborators identify and characterize a novel conserved complex mediating lipid-transport between inner and outer membrane in gram-negative Brucella abortus bacteria
www.embopress.org/doi/full/10....
August 6, 2025 at 5:33 PM
Reposted by Adélie
namurxa.bsky.social
Great work by Adélie Lannoy on Brucella abortus, just published in The EMBO Journal www.embopress.org/doi/full/10..... Thanks to fantastic collaborators! An enigmatic, perhaps ancestral, protein complex predicted as a tunnel-like structure between membranes. Crucial for survival in macrophages
According to Alphafold3 predictions and homology modeling, the Mpc complex is composed of an octameric lipoprotein MpcA anchored at the outer membrane, interacting with a hexameric tunnel-like MpcD, itself associated with an inner membrane complex comprising MpcE and MpcF ATPase. Absence of the Mpc complex modifies the lipid composition of outer membrane vesicles, suggesting that Mpc could be involved in lipid transport between inner and outer membrane.
August 13, 2025 at 1:26 PM
Reposted by Adélie
namurxa.bsky.social
Congratulations to Adélie Lannoy who presented her Ph.D. public defense about a Mla-Pqi chimeric complex and a two component system, both crucial for Brucella abortus virulence
Adélie with the external jury members present at her public defense
January 31, 2025 at 12:07 PM