Adam Broerman
@adambroerman.bsky.social
Dynamic protein designer @uwproteindesign.bsky.social
Pinned
Adam Broerman
@adambroerman.bsky.social
· Nov 20
Excited to join here and announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits.
Reposted by Adam Broerman
If deposition becomes the norm in the field so much information will be unlocked.
If you've ever thought to yourself "self, I wish there was a place that I could share all my molecular dynamics (MD) simulations, to support findability and re-use", I have great news!
I present to you: MDrepo, an open repository of MD simulations for proteins:
academic.oup.com/nar/advance-...
I present to you: MDrepo, an open repository of MD simulations for proteins:
academic.oup.com/nar/advance-...
MDRepo—an open data warehouse for community-contributed molecular dynamics simulations of proteins
Abstract. Molecular Dynamics (MD) simulation of biomolecules provides important insights into conformational changes and dynamic behavior, revealing critic
academic.oup.com
November 20, 2024 at 11:44 PM
If deposition becomes the norm in the field so much information will be unlocked.
Reposted by Adam Broerman
Super excited to share the latest preprint from our lab on macrocycle binder design! Skeetorial (or whatever they are called) to follow soon. Thanks to all the amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Accurate de novo design of high-affinity protein binding macrocycles using deep learning
The development of macrocyclic binders to therapeutic proteins has typically relied on large-scale screening methods that are resource-intensive and provide little control over binding mode. Despite c...
www.biorxiv.org
November 19, 2024 at 7:09 PM
Super excited to share the latest preprint from our lab on macrocycle binder design! Skeetorial (or whatever they are called) to follow soon. Thanks to all the amazing collaborators!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to join here and announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits.
November 20, 2024 at 8:26 AM
Excited to join here and announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits.