Andrea Navas-Olive
@acnavasolive.bsky.social
From synapses to oscillations, what better than hippocampus! Postdoc at @ISTAustria #ripples #memory #deeplearning #models
Google Scholar: https://bit.ly/acnavasolive
Google Scholar: https://bit.ly/acnavasolive
Reposted by Andrea Navas-Olive
Day 5 has an exciting lineup 🤩
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
April 14, 2025 at 1:40 PM
Day 5 has an exciting lineup 🤩
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
@smikulovic.bsky.social talks about helping mice
@nikolaskaralis.bsky.social neuromodulatory circuits
@acnavasolive.bsky.social SWR across species
And me 💁🏽♀️ about theta & movement
#neuroscience
#NeuralMechanismsofCognitiveFunction
sites.google.com/isd.org.br/i...
Reposted by Andrea Navas-Olive
Talk 19:
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
April 14, 2025 at 5:52 PM
Talk 19:
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
Next up is @acnavasolive.bsky.social talking about her impressive research on sharp wave ripple analysis across species in health and disease. Andrea is a phenomenal computational neuroscientist 🤩 and I am so excited to hear her speak for the first time!
Reposted by Andrea Navas-Olive
Cont..
@acnavasolive.bsky.social discussing important considerations for identifying hippocampal ripple events in a recording session and how a convolutional NNs might help their identification.
✅
@acnavasolive.bsky.social discussing important considerations for identifying hippocampal ripple events in a recording session and how a convolutional NNs might help their identification.
✅
April 14, 2025 at 6:16 PM
Cont..
@acnavasolive.bsky.social discussing important considerations for identifying hippocampal ripple events in a recording session and how a convolutional NNs might help their identification.
✅
@acnavasolive.bsky.social discussing important considerations for identifying hippocampal ripple events in a recording session and how a convolutional NNs might help their identification.
✅
Reposted by Andrea Navas-Olive
This is a great application of our topological analysis of the iEEG waveform space to detect and differentiate interictal discharges, ripples and fast ripples in temporal lobe epilepsy in human. Don’t miss the 📝!! www.biorxiv.org/content/10.1... and the Github 👇🏼
March 10, 2025 at 8:27 PM
This is a great application of our topological analysis of the iEEG waveform space to detect and differentiate interictal discharges, ripples and fast ripples in temporal lobe epilepsy in human. Don’t miss the 📝!! www.biorxiv.org/content/10.1... and the Github 👇🏼
Reposted by Andrea Navas-Olive
Here is our paper www.nature.com/articles/s41...
Topological analysis of sharp-wave ripple waveforms reveals input mechanisms behind feature variations - Nature Neuroscience
This study applies topological analysis to hippocampal ripple waveforms, uncovering a low-dimensional continuum that encodes layer-specific synaptic input information. It also reveals how ripple wavef...
www.nature.com
March 10, 2025 at 8:29 PM
Here is our paper www.nature.com/articles/s41...
New preprint about SWRs, this time in HUMANS! 🤩 With @anna-maslarova.bsky.social and @JiyunShin, from @NYU, we’ve (i) developed a pipeline to analyze SWRs in intracranial EEG, and (ii) created ripmap, an open-source toolbox that allows versatile inspection and curation of events 🧵
Spatiotemporal Patterns Differentiate Hippocampal Sharp-Wave Ripples from Interictal Epileptiform Discharges in Mice and Humans
Hippocampal sharp-wave ripples (SPW-Rs) are high-frequency oscillations critical for memory consolidation in mammals. Despite extensive characterization in rodents, their application as biomarkers to ...
www.biorxiv.org
March 10, 2025 at 5:35 PM
New preprint about SWRs, this time in HUMANS! 🤩 With @anna-maslarova.bsky.social and @JiyunShin, from @NYU, we’ve (i) developed a pipeline to analyze SWRs in intracranial EEG, and (ii) created ripmap, an open-source toolbox that allows versatile inspection and curation of events 🧵
Reposted by Andrea Navas-Olive
2025=(1+2+3+4+5+6+7+8+9)² = 1³+2³+3³+4³+5³+6³+7³+8³+9³. 👉🏼 elpais.com/ciencia/cafe...
January 4, 2025 at 8:02 PM
2025=(1+2+3+4+5+6+7+8+9)² = 1³+2³+3³+4³+5³+6³+7³+8³+9³. 👉🏼 elpais.com/ciencia/cafe...
Reposted by Andrea Navas-Olive
More human neurophysiology out today from the Geiger Lab. *Analogue* neuronal output modifies synapses for consolidation during sleep states. With such beautiful data and interpretation it’s easy to forget that the recordings are heroically tough. Fantastic research from @fxmittermaier.bsky.social
Membrane potential states gate synaptic consolidation in human neocortical tissue - Nature Communications
Whether and how slow wave activity (SWA) and the underlying membrane potential UP and DOWN states initiate mechanisms that augment memory functions in humans are not fully understood. Here authors use...
www.nature.com
December 12, 2024 at 7:57 PM
More human neurophysiology out today from the Geiger Lab. *Analogue* neuronal output modifies synapses for consolidation during sleep states. With such beautiful data and interpretation it’s easy to forget that the recordings are heroically tough. Fantastic research from @fxmittermaier.bsky.social
Reposted by Andrea Navas-Olive
With @mojtabart.bsky.social, we applied this to human tissue, and saw that human CA3 cells appear to receive 5 times more DG inputs than mouse cells do! This finding has a lot of potential for powering up our idea of hippocampal computations.
December 11, 2024 at 7:46 PM
With @mojtabart.bsky.social, we applied this to human tissue, and saw that human CA3 cells appear to receive 5 times more DG inputs than mouse cells do! This finding has a lot of potential for powering up our idea of hippocampal computations.
Reposted by Andrea Navas-Olive
Finally, we saw that dentate gyrus input to human CA3 (the ‘teaching’ signal) seemed very high. Luckily, we have @mojtabart.bsky.social and Hans Danzl as neighbours. Their incredible LICONN technology allows light microscopy based connectomics. See the preprint here: www.biorxiv.org/content/10.1...
Light-microscopy based dense connectomic reconstruction of mammalian brain tissue
The information-processing capability of the brain’s cellular network depends on the physical wiring pattern between neurons and their molecular and functional characteristics. Mapping neurons and res...
www.biorxiv.org
December 11, 2024 at 7:46 PM
Finally, we saw that dentate gyrus input to human CA3 (the ‘teaching’ signal) seemed very high. Luckily, we have @mojtabart.bsky.social and Hans Danzl as neighbours. Their incredible LICONN technology allows light microscopy based connectomics. See the preprint here: www.biorxiv.org/content/10.1...
Reposted by Andrea Navas-Olive
Using a Hopfield-like model, @acnavasolive.bsky.social showed that expanding brain size by increasing neuronal number (sparse connectivity) is far better for memory capacity than aiming for dense connectivity (and more inputs per cell). This has some interesting philosophy for brain scaling rules!
December 11, 2024 at 7:46 PM
Using a Hopfield-like model, @acnavasolive.bsky.social showed that expanding brain size by increasing neuronal number (sparse connectivity) is far better for memory capacity than aiming for dense connectivity (and more inputs per cell). This has some interesting philosophy for brain scaling rules!
Reposted by Andrea Navas-Olive
In a fantastic collaboration with Prof Karl Rössler (MedUniWien), we applied multicell patch-clamp to human hippocampus resected from epilepsy patients. Some samples show sclerosis (disease-led cell loss), but many are perfectly intact. This is the closest to 'wildtype’ human physiology we can get..
December 11, 2024 at 7:46 PM
In a fantastic collaboration with Prof Karl Rössler (MedUniWien), we applied multicell patch-clamp to human hippocampus resected from epilepsy patients. Some samples show sclerosis (disease-led cell loss), but many are perfectly intact. This is the closest to 'wildtype’ human physiology we can get..
Reposted by Andrea Navas-Olive
We explored CA3, which in theory stores and retrieves memories from interconnected ensembles of pyramidal neurons. With Victor Vargas-Barroso and Rebecca Morse, we looked for these networks using octopatch. From 8 patients and 56 slices we found just 10 connected pairs! (under 1% connectivity)..
December 11, 2024 at 7:46 PM
We explored CA3, which in theory stores and retrieves memories from interconnected ensembles of pyramidal neurons. With Victor Vargas-Barroso and Rebecca Morse, we looked for these networks using octopatch. From 8 patients and 56 slices we found just 10 connected pairs! (under 1% connectivity)..
Reposted by Andrea Navas-Olive
To touch base with better characterised circuits, we recorded in neocortex and saw the same dense connectivity that @yangfanpeng.bsky.social, @alleninstitute.bsky.social and others see. In fact CA3 wasn’t just sparse, but gets sparser from mice to humans - opposite scaling to neocortical circuits!
December 11, 2024 at 7:46 PM
To touch base with better characterised circuits, we recorded in neocortex and saw the same dense connectivity that @yangfanpeng.bsky.social, @alleninstitute.bsky.social and others see. In fact CA3 wasn’t just sparse, but gets sparser from mice to humans - opposite scaling to neocortical circuits!
Reposted by Andrea Navas-Olive
We had the first view on human hippocampal synaptic pairs, and they look slow and integrating as we would expect (perfect for associations!). However they were also much more reliable and precise than seen in rodent research.
December 11, 2024 at 7:46 PM
We had the first view on human hippocampal synaptic pairs, and they look slow and integrating as we would expect (perfect for associations!). However they were also much more reliable and precise than seen in rodent research.
Reposted by Andrea Navas-Olive
As you may expect, human neurons were larger than mouse cells, but spine density was a lot lower, so the number of inputs from other neurons in the recurrent network doesn’t change so much. Low spine density and reliable synapses have been seen in other brain areas, so may be human circuit features
December 11, 2024 at 7:46 PM
As you may expect, human neurons were larger than mouse cells, but spine density was a lot lower, so the number of inputs from other neurons in the recurrent network doesn’t change so much. Low spine density and reliable synapses have been seen in other brain areas, so may be human circuit features
Reposted by Andrea Navas-Olive
A bigger difference between human and mouse brains is the number of neurons. This has gone up by about 17 times in CA3! By (very) simple maths, our anatomy data predicts connectivity in a random recurrent network to be pretty much in line with what we record experimentally for CA3 across species.
December 11, 2024 at 7:46 PM
A bigger difference between human and mouse brains is the number of neurons. This has gone up by about 17 times in CA3! By (very) simple maths, our anatomy data predicts connectivity in a random recurrent network to be pretty much in line with what we record experimentally for CA3 across species.
Reposted by Andrea Navas-Olive
We think this explains the connectivity and circuit scaling between brain areas - dense local circuits in neocortex, while hippocampal CA3 forms something like one big recurrent network - perfect for associating all the hippocampus’ incoming info. Circuits made to measure!
December 11, 2024 at 7:46 PM
We think this explains the connectivity and circuit scaling between brain areas - dense local circuits in neocortex, while hippocampal CA3 forms something like one big recurrent network - perfect for associating all the hippocampus’ incoming info. Circuits made to measure!
Reposted by Andrea Navas-Olive
Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few
Human hippocampal CA3 uses specific functional connectivity rules for efficient associative memory
Human hippocampal CA3 networks use sparse and broad synaptic connectivity, and their recurrent synapses employ reliability, precision, and long integration times to enhance memory capacity. Thus, the human hippocampus is distinct from both rodent counterparts and human neocortical circuits.
www.cell.com
December 11, 2024 at 7:46 PM
Is neuroscience research really working to understand the human brain? Or do we get lost in mouse cognition? I’ve asked myself this a lot since starting to work with human tissue. Our first Jonas Lab foray into untangling human hippocampal circuits is now online! www.cell.com/cell/fulltex... 1/a few
Reposted by Andrea Navas-Olive
Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art.
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
December 4, 2024 at 8:55 PM
Now that we’re on Bluesky, it’s a good time to bring back #badsciencedrawings – a collection of figures that prove that science is more science than art.
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
Before Biorender, all we had was MS Paint and a dream. But ovals, lines, and lightning bolts were all we needed
Morales-Botello et al., 2012
So nice to see science sparking again 🦋 Hello everyone!
November 19, 2024 at 9:15 PM
So nice to see science sparking again 🦋 Hello everyone!
Reposted by Andrea Navas-Olive
This paper is incredible. EM level connectomics on a light microscope.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 14, 2024 at 1:22 AM
This paper is incredible. EM level connectomics on a light microscope.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andrea Navas-Olive
Following the great migration! Leading the @lmprida.bsky.social lab. Hippocampal circuits, oscillations and memory.
November 14, 2024 at 6:40 AM
Following the great migration! Leading the @lmprida.bsky.social lab. Hippocampal circuits, oscillations and memory.
Reposted by Andrea Navas-Olive
go.bsky.app/LdtUYZS
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
November 12, 2024 at 9:00 PM
go.bsky.app/LdtUYZS
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet
I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent.
Tell me who I haven’t found yet