Arthur Charles-Orszag
@acharlesorszag.bsky.social
Assistant Professor at UC Davis. Cell biologist interested in archaea and evolution. UCSF & Institut Pasteur alum. He/him 🇫🇷 🏳️🌈
https://www.charlesorszaglab.com/
https://www.charlesorszaglab.com/
Welcome to our first postdoc in the ACO Lab, Andy Garcia! 🎉
September 15, 2025 at 8:10 PM
Welcome to our first postdoc in the ACO Lab, Andy Garcia! 🎉
Supporting each other as #newPI is very important, and @antonioserapio.bsky.social is great at it
September 1, 2025 at 10:51 PM
Supporting each other as #newPI is very important, and @antonioserapio.bsky.social is great at it
Archaeal S-layer proteins can adopt different symmetries that can locally accommodate areas of high curvature. The S-layer is also involved in the control of turgor and osmotic pressure, ion transport, cell-cell interactions and mating.
May 29, 2025 at 4:45 PM
Archaeal S-layer proteins can adopt different symmetries that can locally accommodate areas of high curvature. The S-layer is also involved in the control of turgor and osmotic pressure, ion transport, cell-cell interactions and mating.
The S-layer is the most widespread and fundamental component of archaeal cell envelopes and may represent one of the earliest and most fundamental cell wall polymers found in microorganisms
May 29, 2025 at 4:43 PM
The S-layer is the most widespread and fundamental component of archaeal cell envelopes and may represent one of the earliest and most fundamental cell wall polymers found in microorganisms
Coolest office poster, the Beaud - Gribaldo ToL 😎 Thank you @sgribaldo.bsky.social and @babebe.bsky.social 🫶🏼
April 17, 2025 at 10:37 PM
Coolest office poster, the Beaud - Gribaldo ToL 😎 Thank you @sgribaldo.bsky.social and @babebe.bsky.social 🫶🏼
(5/5)
The structure of full-length SegB in S. acidocaldarius sheds light on conserved motifs, but also variable ones. We propose that non-conserved regions in SegB homologs emerged through expansion mutations, while retaining the overall SegB fold necessary for interaction with SegA and DNA.
The structure of full-length SegB in S. acidocaldarius sheds light on conserved motifs, but also variable ones. We propose that non-conserved regions in SegB homologs emerged through expansion mutations, while retaining the overall SegB fold necessary for interaction with SegA and DNA.
April 16, 2025 at 7:00 PM
(5/5)
The structure of full-length SegB in S. acidocaldarius sheds light on conserved motifs, but also variable ones. We propose that non-conserved regions in SegB homologs emerged through expansion mutations, while retaining the overall SegB fold necessary for interaction with SegA and DNA.
The structure of full-length SegB in S. acidocaldarius sheds light on conserved motifs, but also variable ones. We propose that non-conserved regions in SegB homologs emerged through expansion mutations, while retaining the overall SegB fold necessary for interaction with SegA and DNA.
(4/5)
SegA also seems to promote chromosome compaction, possibly assisting SegB clustering and collective segregation of all three origins of replication and suggesting that archaeal ParA-like proteins have evolved additional functions compared to bacteria.
SegA also seems to promote chromosome compaction, possibly assisting SegB clustering and collective segregation of all three origins of replication and suggesting that archaeal ParA-like proteins have evolved additional functions compared to bacteria.
April 16, 2025 at 6:59 PM
(4/5)
SegA also seems to promote chromosome compaction, possibly assisting SegB clustering and collective segregation of all three origins of replication and suggesting that archaeal ParA-like proteins have evolved additional functions compared to bacteria.
SegA also seems to promote chromosome compaction, possibly assisting SegB clustering and collective segregation of all three origins of replication and suggesting that archaeal ParA-like proteins have evolved additional functions compared to bacteria.
(3/5)
We show that all SegB-encoding archaea are non-rod-shaped, suggesting that SegB was selected in the ancestor of all Sulfolobaceae for generating an axis for bipolar chromosome segregation in these spherical cells— – i.e. cells that lack apparent poles.
We show that all SegB-encoding archaea are non-rod-shaped, suggesting that SegB was selected in the ancestor of all Sulfolobaceae for generating an axis for bipolar chromosome segregation in these spherical cells— – i.e. cells that lack apparent poles.
April 16, 2025 at 6:58 PM
(3/5)
We show that all SegB-encoding archaea are non-rod-shaped, suggesting that SegB was selected in the ancestor of all Sulfolobaceae for generating an axis for bipolar chromosome segregation in these spherical cells— – i.e. cells that lack apparent poles.
We show that all SegB-encoding archaea are non-rod-shaped, suggesting that SegB was selected in the ancestor of all Sulfolobaceae for generating an axis for bipolar chromosome segregation in these spherical cells— – i.e. cells that lack apparent poles.
(2/5)
Unlike gradient-forming ParA in rod-shaped bacteria, we show that SegA assembles an elongated structure whose orientation depends on two discrete, polarly localized SegB foci in dividing cells.
Unlike gradient-forming ParA in rod-shaped bacteria, we show that SegA assembles an elongated structure whose orientation depends on two discrete, polarly localized SegB foci in dividing cells.
April 16, 2025 at 6:57 PM
(2/5)
Unlike gradient-forming ParA in rod-shaped bacteria, we show that SegA assembles an elongated structure whose orientation depends on two discrete, polarly localized SegB foci in dividing cells.
Unlike gradient-forming ParA in rod-shaped bacteria, we show that SegA assembles an elongated structure whose orientation depends on two discrete, polarly localized SegB foci in dividing cells.
Preprint alert! I’m publishing my last paper from my postdoc work on archaeal cell biology, with @mullinslab.bsky.social, @archaellum.bsky.social, @samjlord.bsky.social, @marleenvw.bsky.social, @arghya93.bsky.social, and more great folks (thread below with more details)
April 16, 2025 at 6:55 PM
Preprint alert! I’m publishing my last paper from my postdoc work on archaeal cell biology, with @mullinslab.bsky.social, @archaellum.bsky.social, @samjlord.bsky.social, @marleenvw.bsky.social, @arghya93.bsky.social, and more great folks (thread below with more details)
Micron-sized Valentine’s Day card to y’all 🫶🏼
February 14, 2025 at 7:38 PM
Micron-sized Valentine’s Day card to y’all 🫶🏼
Archaea Power Hour doesn’t have a BlueSky yet (soon!) but here’s the lineup for tomorrow’s APH virtual conference!
December 10, 2024 at 11:14 PM
Archaea Power Hour doesn’t have a BlueSky yet (soon!) but here’s the lineup for tomorrow’s APH virtual conference!
Post a photo of yourself from a different era (pre-eukaryogenesis half me. Really brings you back!
Credit Rodrigues-Oliveira et al. 2023)
Credit Rodrigues-Oliveira et al. 2023)
November 28, 2024 at 10:23 PM
Post a photo of yourself from a different era (pre-eukaryogenesis half me. Really brings you back!
Credit Rodrigues-Oliveira et al. 2023)
Credit Rodrigues-Oliveira et al. 2023)