Abraham Gihawi
@abrahamgihawi.bsky.social
UEA Research Fellow - Bioinformatics - Cancer (meta)genomics since 2017.
Opinions are mine alone.
Opinions are mine alone.
Many thanks to @danbrewer.bsky.social for your support and guidance through the years and to the other co-authors, funders, @genomicsengland.bsky.social and patients that made this work possible.
September 3, 2025 at 7:02 PM
Many thanks to @danbrewer.bsky.social for your support and guidance through the years and to the other co-authors, funders, @genomicsengland.bsky.social and patients that made this work possible.
We demonstrate some microbial patterns hold real clinical promise — from detecting infectious disease to uncovering potential prognostic markers.
Read more here 👉 www.science.org/doi/10.1126/...
Read more here 👉 www.science.org/doi/10.1126/...
The landscape of microbial associations in human cancer
Differences between cancer types, infectious disease, and potential prognostic markers are uncovered by studying microbes within cancer DNA.
www.science.org
September 3, 2025 at 7:00 PM
We demonstrate some microbial patterns hold real clinical promise — from detecting infectious disease to uncovering potential prognostic markers.
Read more here 👉 www.science.org/doi/10.1126/...
Read more here 👉 www.science.org/doi/10.1126/...
We also see the same patterns in other datasets:
📊 PCAWG
📊 TCGA - Cleaner signals produced by a fantastic paper today from Peter Ge, @stevensalzberg.bsky.social & team)
www.science.org/doi/10.1126/...
📊 PCAWG
📊 TCGA - Cleaner signals produced by a fantastic paper today from Peter Ge, @stevensalzberg.bsky.social & team)
www.science.org/doi/10.1126/...
Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project
An analysis of TCGA whole-genome sequencing samples yields a comprehensive resource for investigating the role of microbes in cancer.
www.science.org
September 3, 2025 at 7:00 PM
We also see the same patterns in other datasets:
📊 PCAWG
📊 TCGA - Cleaner signals produced by a fantastic paper today from Peter Ge, @stevensalzberg.bsky.social & team)
www.science.org/doi/10.1126/...
📊 PCAWG
📊 TCGA - Cleaner signals produced by a fantastic paper today from Peter Ge, @stevensalzberg.bsky.social & team)
www.science.org/doi/10.1126/...
The results hold up across methods:
✅ Conventional statistics
✅ Machine learning
✅ Dimensionality reduction
✅ Conventional statistics
✅ Machine learning
✅ Dimensionality reduction
September 3, 2025 at 7:00 PM
The results hold up across methods:
✅ Conventional statistics
✅ Machine learning
✅ Dimensionality reduction
✅ Conventional statistics
✅ Machine learning
✅ Dimensionality reduction
In our new paper, we dig into Genomics England’s 100,000 Genomes Project.
We find distinct microbial signals in colorectal cancer (and to a lesser extent oral cancer)
We find distinct microbial signals in colorectal cancer (and to a lesser extent oral cancer)
September 3, 2025 at 7:00 PM
In our new paper, we dig into Genomics England’s 100,000 Genomes Project.
We find distinct microbial signals in colorectal cancer (and to a lesser extent oral cancer)
We find distinct microbial signals in colorectal cancer (and to a lesser extent oral cancer)
Some microbes are well known in cancer:
🦠 Hepatitis → liver cancer
🦠 HPV → cervical & oral cancers
But beyond these, can microbial DNA really help distinguish tumour types?
🦠 Hepatitis → liver cancer
🦠 HPV → cervical & oral cancers
But beyond these, can microbial DNA really help distinguish tumour types?
September 3, 2025 at 7:00 PM
Some microbes are well known in cancer:
🦠 Hepatitis → liver cancer
🦠 HPV → cervical & oral cancers
But beyond these, can microbial DNA really help distinguish tumour types?
🦠 Hepatitis → liver cancer
🦠 HPV → cervical & oral cancers
But beyond these, can microbial DNA really help distinguish tumour types?